ACTIVITY, MOTOR CONTROL & COORDINATION • SPONTANEOUS PAIN - POSTURAL DEFICIT • PAIN - THERMAL ALLODYNIA / HYPERALGESIA • PAIN - MECHANICAL ALLODYNIA / HYPERALGESIA • ANXIETY & DEPRESSION DISORDER • LEARNING - MEMORY - ATTENTION - ADDICTION • PHARMACOLOGY & PHYSIOLOGICAL PARAMETERS • SURGERY & STEREOTAXY EQUIPMENT • METABOLISM A QUICK, EASY TO USE AND RELIABLE INSTRUMENT TO ASSESS THRESHOLD SENSITIVITY SMALGO SMall Animal ALGOmeter INSTRUMENT OVERVIEW Bioseb’s SMALGO (SMall animal ALGOmeter) is a new pressure-based analgesimeter especially designed for small animals like rats and mice. Bioseb’s SMALGO fits on your finger (thumb or index) and allows to easily apply a force or pressure on the desired location. Designed for OA quantification, it is generally used on the knee joint or on the lumbar vertebrae for low back pain assessment. HOW DOES IT WORK? Once the operator adjusted the algometer to their index or thumb, and thanks to the miniature size of the apparatus, they can apply a progressive pressure to the relevant location on the animal, as if they were applying the pressure directly with their own finger. The pressure value triggering an escape reaction is automatically determined and displayed on the screen of the instrument. The sensor as a 1500 grammes capacity with 0,1% accuracy and so can be used for both rats and mice - two different rounded bits with different surfaces are provided to fit the different species and applications. The BIO-CIS software is included and allows to display the force and can be used either to train on the way the force is applied (repeatability) or to compare and discard extra limits trials. The threshold sensitivity of the animal (rats or mice) is quickly and reliably determined by applying a progressive force. The threshold is immediately displayed on the electronic device in grams or Newtons. SMALGO can also be used for screening purposes applying a known force for a considered period. KEY FEATURES • EASY TO USE AND RELIABLE • WORKS FOR BOTH RATS AND MICE • CAN BE USED TO DETERMINE PAIN THRESHOLD WITH A PROGRESSIVE FORCE • CAN BE USED TO SCREEN DRUGS WITH A GIVEN FORCE • THRESHOLD IS IMMEDIATELY DISPLAYED • PRESSURE VALUE TRIGGERING AN ESCAPE REACTION IS AUTOMATICALLY DETERMINED • INCLUDES A SOFTWARE FOR DATA TRANSFER TO EXCEL • OPTIONAL USB FOOTSWITCH LETS YOU RESET THE DISPLAY WITH HANDS FREE • A MUST FOR OSTEO-ARTHRITIS AND PAIN STUDIES An innovative sensor Bioseb’s SMALGO fits on your finger (thumb or index) and allows to easily apply a force or pressure on the desired location. Designed for OA quantification, it is generally used on the knee joint or on the lumbar vertebrae for low back pain assessment. Phone: North America +1 727 521 1808 - Europe & other Areas +33 442 344 360 -

SMALGO: Bioseb’s SMall Animal ALGOMETER DEDICATED SOFTWARE An embedded statistical computation has been included in the electronic device. This is a very useful feature that as been very well received and used by users of large numbers of tests. The display shows in real time the mean, standard deviation and variation coefficient from groups of animals. The included BIO-CIS software sends datas acquired via the SMALGO Algometer into a MS Excel sheet using the RS232 port and USB converter. Easy to set up, this soft interface also allows the display of the applied force vs. time for different trials,...