ACTIVITY, MOTOR CONTROL & COORDINATION • SPONTANEOUS PAIN - POSTURAL DEFICIT • PAIN - THERMAL ALLODYNIA / HYPERALGESIA • PAIN - MECHANICAL ALLODYNIA / HYPERALGESIA • ANXIETY & DEPRESSION DISORDER • LEARNING MEMORY - ATTENTION - ADDICTION • PHARMACOLOGY & PHYSIOLOGICAL PARAMETERS • SURGERY & STEREOTAXY EQUIPMENT • METABOLISM MEETING YOUR NEEDS BY DESIGNING INNOVATIVE AND HIGH-QUALITY SOLUTIONS FOR YOUR RESEARCH MAIN INSTRUMENTS • Dynamic Weight Bearing • Electronic Von Frey • Cold/Hot Plate Test Phone: North America +1 727 521 1808 - Europe & other Areas +33 442 344 360 - Email: info@bioseb

ACTIVITY, MOTOR CONTROL & COORDINATION • SPONTANEOUS PAIN - POSTURAL DEFICIT • PAIN - THERMAL ALLODYNIA / HYPERALGESIA • PAIN - MECHANICAL ALLODYNIA / HYPERALGESIA • ANXIETY & DEPRESSION DISORDER • LEARNING - MEMORY - ATTENTION - ADDICTION • PHARMACOLOGY & PHYSIOLOGICAL PARAMETERS • SURGERY & STEREOTAXY EQUIPMENT • METABOLISM AN EFFICIENT AND ADVANCED ALTERNATIVE TO TRADITIONAL INCAPACITANCE TESTS FOR ASSESSING PAIN SENSITIVITY DWB: Advanced Dynamic Weight Bearing 2.0 INSTRUMENT OVERVIEW Bioseb’s Advanced Dynamic Weight Bearing Test is the result of years of R&D based on the principles of early...

DEDICATED SOFTWARE Parameters measured: • Weight for each paw (g and % total animal weight) • Weight for grouped front and rear paws (g and % total animal weight) • Left/Right and Front/Rear weight ratio • Surface for grouped front and rear paws (mm2) • Variability (standart deviation/mean) for each parameter • Parameters given for each posture and as a mean for the whole experiment • Total time spent on each paw over the whole experiment (s) • Duration of different postures (4 paws, rearing...) over the whole experiment (s) • Total time spent on each paw over the whole experiment (s) SYSTEM...

PAIN - MECHANICAL ALLODYNIA / HYPERALGESIA A QUICK & EASY YET POWERFUL ELECTRONIC SOLUTION TO DETERMINE RODENTS' MECHANICAL SENSITIVITY THRESHOLD HOW DOES IT WORK? The electronic model of Von-Frey filament combines ease-of-use and rapidity for the determination of the mechanical sensitivity threshold in rodent. A tip is applied against the central edge of the animal hind paw. Paw withdrawal caused by the stimulation is registered as a response. The corresponding force applied is recorded by the system and displayed on the large backlighted screen of the Von-Frey unit with a resolution of 0.1...

ACTIVITY, MOTOR CONTROL & COORDINATION • SPONTANEOUS PAIN - POSTURAL DEFICIT • PAIN - THERMAL ALLODYNIA / HYPERALGESIA • PAIN - MECHANICAL ALLODYNIA / HYPERALGESIA • ANXIETY & DEPRESSION DISORDER • LEARNING - MEMORY - ATTENTION - ADDICTION • PHARMACOLOGY & PHYSIOLOGICAL PARAMETERS • SURGERY & STEREOTAXY EQUIPMENT • METABOLISM INCLUDES AN EMBEDDED CAMERA INSIDE THE STIMULATOR & A DEDICATED SOFTWARE REVOLUTIONIZING THE EXPERIMENT Electronic Von Frey ith with Embedded Video INSTRUMENT OVERVIEW We know that one of the main issue with Electronic Von Frey instruments is the necessity for the operator...

PAIN - MECHANICAL ALLODYNIA / HYPERALGESIA BIOSEBIn Vivo Research Instruments INCLUDES AN EMBEDDED CAMERA INSIDE THE STIMULATOR & A DEDICATED SOFTWARE REVOLUTIONIZING THE EXPERIMENT OPTIONS • A patient switch allows to freeze the displayed value when the threshold is reached • A USB connexion allows to transfer the displayed value onto a computer • New, robust and modular cages to gently hold rodents (rats or mice) during nociceptive and analgesic tests including Hargreaves and Von Frey protocols: an innovative, solid, practical and user-friendly design by Bioseb. DOMAINS OF APPLICATION • Phenotyping...

PAIN - THERMAL ALLODYNIA / HYPERALGESIA AN INNOVATIVE, ACCURATE AND EASY-TO-USE INSTRUMENT FOR YOUR RESEARCH ON ANALGESIA Set the plate to the chosen temperature and wait for the thermometer to display it has been achieved. Place the subject on plate within the enclosure and start the built-in chronometer using the button on the front panel or the foot pedal. The operator stops the chronometer when the animal demonstrates a nociceptive response, such as paw lick, hind paw withdrawal, or jump. Reaction time remains displayed in seconds on the front panel until zeroed. Bioseb designed the CHP as...

BIO-CHP: Cold/Hot Plate DEDICATED SOFTWARE Though it is functional as a stand-alone instrument, the Cold Hot Plate Test Analgesia Meter can also be used with optional software, allowing the user to define temperature «ramps» and «Loops». • Software controls the temperature for generation of a continuous and reproducible ramp or loop • Ramps allow for identification of the precise nociceptive behavior-inducing temperature for each subject • Loop protocol design is useful for subject acclimation • Pre-set temperature limits can be programmed to prevent damage to animal's paws and minimize pain/stress...