OxyCycler GT41
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OxyCycler GT41Gasotransmitter Ready O2/CO2 Culture System • First Gasotransmitter Upgradeable Cell Culture System • Precise Automated Exposures of O2 and CO2 • Dynamic or Static Exposures • Simulate Physiologic and Pathophysiologic Conditions • Unprecedented O2 Phenotypes • Upgrade with CO or NO or both CO and NO ADVANCED GASOTRANSMITTER INCUBATION The OxyCycler GT41 is a powerful controller with unique capabilities for subchamber culture systems. It fits subchambers using an advanced adapter plate with a versatile multipod sensor assembly. This assembly makes it quick and easy to add or change control functions. UNLIMITED PROGRAMMED, DYNAMIC EXPOSURES The GT41 can work as a fully functional, stand-alone controller providing advanced oxygen (O2) and carbon dioxide (CO2) range control with humidity limiting for simulating physiologic and pathophysiologic O2. With static or programmable dynamic O2 control, it can create a wide variety of hypoxic and hyperoxic exposures, as well as cell normoxia, which is normally much lower than room air or oxygen levels in CO2 incubators. MODULAR FLEXIBILITY In addition, the GT41 based subchamber culture systems can be upgraded with gasotransmitter control. As the core controller in a set of controllers it can be configured to work with different piggyback controller combinations to create CO and NO gasotransmitter culture systems. The GT41 is often used as a starter set for later upgrade. Since many pathophysiologic O2 events and gasotransmitter responses are interrelated, eventually simulating physiologic and pathophysiologic carbon monoxide (CO) and/ or nitric oxide (NO) in these cell cultures offers an attractive upgrade path in gasotransmitter research laboratories. No other subchamber controller offers this unique and powerful upgrade option.

How It Works OxyCycler GT41 Culture System. Controls dynamic or static O2, CO2, and limits RH in subchamber. Fits most standard incubators. Supply gases required: Oxygen, Nitrogen, and Carbon Dioxide. Calibration gas required: certified pre-mix of 10% CO2 in balance oxygen. Hot swap multipod adapter plate provides microbial barrier filters between cells culturing in the subchamber and all of the sensors and mechanisms that control O2, CO2, RH, CO, NO/NO2 and temperature. Hot swap multipods provide upgrade flexibility and immediate, easy maintenance. A pump draws a sample of the controlled...

Multiple and Independent Gas Profiling Acute/Intermittent Hypoxia 20% Hypoxic stress can model components of many severe diseases such as heart attacks, strokes, asthma, or epilepsy. Frequency, duration and degree of drops are all adjustable. Hours Cells destined for implantation will experience hypoxia and may be better prepared if they are conditioned to it before implantation. Ischemia may also be protected by conditioning. The OxyCycler GT41 can easily run any preconditioning profile. Graded Hypoxia HUMIDITY IS NORMALLY NEGLECTED Despite the undesired consequences of condensation,...

HOST CHAMBER TEMPERATURE: 5-40°C HOST CHAMBER HUMIDITY: 5-95% Sensor Operational Parameters 1. Controller: Bright blue digits on black back ground. Continuously displays current control gas level, control status, and alarm status in all chambers. Displays menu items and settings during programming. 2. Bleed Valves and Barbs: Bleeds gases out of gas supply lines. Calibration cup for sensor attaches here. 3. ZERO Calibration Gas Flowmeter: Used for calibration. 4. SPAN Calibration Gas Flowmeter: Used for calibration. 5. Needle Valves: Sets infusion rate of control gases in each chamber to...