CO and NO Subchamber Cell Culture System CytoCentric Products • First Dual CO/NO Gasotransmitter Cell Culture System • Precise Automated Exposures of CO and NO • Dynamic or Static Exposures • Simulate Physiologic and Pathophysiologic conditions • Unprecedented CO Induced Phenotypes • Unprecedented NO Induced Phenotypes 0-400ppm CO and 0-50ppm NO ADVANCED GASOTRANSMITTER INCUBATION Carbon monoxide and nitric oxide are both important gasotransmitters with a wide variety of similar, overlapping, and different functions. Now it is possible to study them independently or simultaneously in cell culture without the difficulty of chemical donors. The OxyCycler GT4181CN is the only dual gasotransmitter cell culture system providing control of both CO and NO. It creates the ultimate incubator accessory when controlling CO and/or NO in a subchamber culture system. UNLIMITED PROGRAMMED, DYNAMIC EXPOSURES Consisting of a GT41 which provides the common O2, CO2, and RH control, and the modular GT81CN piggyback controller, which provides not only the CO and NO range control but also NO2 limiting, the combo can create virtually any type of dynamic or static exposure your cells might need. MODULAR FLEXIBILITY The controller is compatible and will fit any standard size C-Chamber. The entire system will fit any existing incubator. The GT series all use the same multipod adapter plate. This attaches to a C-Chamber and sits within your incuba

Installation Schematic OxyCycler GT4181CN Culture System. Controls dynamic or static O2, CO2, CO and NO, and limits RH and NO2 in subchamber. Supply gases to GT41 required: Oxygen, Nitrogen, Carbon Dioxide. Calibration gas to GT41 required: certified pre-mix of 10% CO2 in balance oxygen. Supply gases to GT81CN: non-certified pre-mix of 10000ppm CO in balance nitrogen, and non-certified pre-mix of 1000ppm NO in balance nitrogen. Calibration gases to GT81CN required: certified pre-mix of 300ppm CO in balance nitrogen, certified pre-mix of 30ppm NO in balance nitrogen, and certified pre-mix 10ppm...

Hypoxic stress can model components of many severe diseases such as heart attacks, strokes, asthma, or epilepsy. Frequency, duration and degree of drops are all adjustable. Cells destined for implantation will experience hypoxia and may be better prepared if they are conditioned to it before implantation. Ischemia may also be protected by conditioning. The OxyCycler GT4181CN can easily run any preconditioning profile. Acute Hyperoxia Graded Hypoxia Model step reduction in oxygen, similar to altitude acclimation, to gradually condition cells for hypoxic upregulation of gene expression. The rate...

HOST CHAMBER TEMPERATURE: 5-40°C HOST CHAMBER HUMIDITY: 15-90%, Non-Condensing Sensor Operational ParametersFront and Back Panels GT81CN 1. Bleed Valves and Barbs: Bleeds gases out of gas supply lines. Calibration cup for sensor attaches here. 2. Controller: Bright blue digits on black back ground. Continuously displays current control gas level, control status, and alarm status in all chambers. Displays menu items and settings during programming. 3. Alarm: Will sound if Ambient gas monitor detects unsafe levels. 4. ZERO Calibration Gas Flowmeter: Used for calibration. 5. SPAN Calibration Gas...