Improve your knowledge about the Zymo-Teck® process by selecting the QR-Code on the right. Preserved bone collagen Grafting bone collagen into the defect creates a precise biological condition: osteoblasts, the cells responsible for the formation of new bone tissue, produce collagen fibers that are then saturated by calcium minerals. It's the same three-dimensional structure of collagen that allows the nucleation of crystals of bone apatite, through a physical phenomenon called epitaxy. In addition, the type I bone collagen stimulates, both at cellular and subcellular level, an extremely high number of processes involved in bone regeneration. The presence of bone collagen in OX® is also demonstrated in polarised light: collagen fibres, having a regular texture, presents a refractivity characteristic that makes it look lighter. Bioteck® is an Italian company producing bone substitutes and protective membranes that are successfully used in orthopaedics, neurosurgery, oral and maxillofacial surgery. Founded in 1995, the company continues to grow constantly and now operates in more than 50 countries around the world. A firm commitment to scientific research forms the basis for the innovative solutions offered by Bioteck® products. The company collaborates on numerous national and international research projects, which have driven the basic research and helped in writing important chapters in bone biology. The in-depth knowledge acquired by Bioteck® through its research ensures the absolute quality of its products, which are subjected to strict environmental and quality controls, thereby guaranteeing a product meeting the highest quality and safety standards. Bioteck® applies a policy of total transparency, opening up the doors of its Production and R&D Center for the monitoring of its innovative process and the intense scientific research carried out by its staff. bioteck.com In over twenty years of scientific research and clinical practice, Bioteck® has made an important contribution to the clinical/scientific knowledge in the field of tissue biology. The Bioteck Academy is the meeting place of all the excellences that continuously contribute to the development of this knowledge and Bioteck® products. The Academy has developed a culture of sharing scientific knowledge aimed at the dissemination of best techniques and practices in the various areas of regenerative surgery and is open to all professionals who decide to participate in this activity by sharing their surgical experience. More information on the activities of the Academy can be found at: www.bioteckacademy.com . Total remodeling OSTEOXENON® is reworked and reabsorbed through the action of osteoclasts. This happens with entirely physiologic kinetics: as well as the patient’s bone it is fully remodeled within 8-12 months, as it happens for OSTEOXENON®: after this period it is completely replaced by the patient's bone. This is possible because OX®, unlike other materials, is recognized as the optimum substrate by osteoclasts that reabsorb it physiologically; only in this case, in fact, the regenerative process may end with the complete replacement of the graft. If the material is remodeled and is reabsorbed physiologically there can be no loss of volume. If the material is reabsorbed too quickly (e.g. calcium phosphate) or too slowly (e.g. synthetic hydroxyapatites) the volume of new endogenous bone is not equal to the grafted volume. OSTEOXENON®, however, by remodeling itself through osteoclastic activity, it keeps the grafted volume. Production and R&D Center: Via G. Agnelli, 3 - 10020 Riva Presso Chieri (Turin) - Italy. Bioteck®, a leader in the production of tissue substitutes of natural origin, has developed the exclusive deantigenation Zymo-Teck® process. The Zymo-Teck® process, unlike other processes based on high temperature treatments or using chemical solvents, uses enzymes, natural proteins able to precisely and selectively remove the various unwanted substances, making the tissues completely bio-compatible and devoid of treatment residues. Zymo-Teck® also preserves useful molecules, such as collagen in its natural structure and, operating at controlled temperatures, does not alter the structural characteristics of the tissues. The stringent in-line quality controls implemented by Bioteck® at all stages of processing guarantee the highest quality of grafts: to obtain the best surgical outcome. Bioteck S.p.A. Headquarters: Via E. Fermi 49 - 36057 Arcugnano (Vicenza) - Italy Tel. +39 0444 289366 - fax: +39 0444 285272 [email protected] - www.bioteck.com concept: mauro forlani - vi Zymo-Teck® process: the secret of the quality of grafts and membranes Complete line of collagenated bone substitutes and membranes ENZYMATIC DEANTIGENATION PRESERVED BONE COLLAGEN TOTAL REMODELING

Application table BLOCKS OX51 Cancellous block OX52 Cancellous block OX05R Cancellous- cortical block Granules in vial OX30 OX37 OX38 Cancellous Granules 0.5-1.0 mm OX40 Slow resorption Cortical Granules 0.5-1.0 mm OX21 0X22 0X23 Cancellous Cortical Granules 0.5-1.0 mm Flex Sheets OX01 Cancellous Flex 25x25x3 mm OX03 BCG-XC30 OX04 Collagen Cortical Membrane Membrane 30x25x0.2 mm 25x25x0.2 mm 50x25x0.2 mm Periodontal defect (very small, difficult access) OX33 Cancellous OX34 Cancellous OX36 Cancellous Periodontal defect - Infrabony defects (1-3 walls) - Furcation defects (class I or II) OX01 Flexible...