Clinically proven Highly deliverable Vascular Intervention // Coronary Drug-Eluting Stent System Technical data / ordering info

Clinically proven Extensive clinical program* >32,500 patients enrolled >50,500 patients planned in total >44 studies ongoing >55 studies planned in total Outstanding clinical results even in challenging subgroups Orsiro has demonstrated consistently low target lesion failure (TLF) in all-comers trials compared to major modern drug-eluting stents (DES). Orsiro BIOTRONIK Synergy Boston Scientific Resolute Integrity Medtronic Orsiro BIOTRONIK Xience Prime/ Xpedition Abbott Orsiro BIOTRONIK Nobori Terumo Small vessels patients planned in total

The new benchmark for DES BIOFLOW-V 12-month clinical outcomes compared to Xience In a post-hoc analysis of pooled patient-level data from three RCTs, Orsiro achieved a 96.9% probability of superiority* on TLF rate versus Xience.10 BIOFLOW-V / -IV / -II Bayesian Population (n=2,208) Orsiro BIOTRONIK Xience Abbott * osterior probability, Bayesian analytical methods were applied P Proven long term clinical outcomes All stents implanted from 2007 until January 11, 2017 unadjusted (SCAAR)11,12 Cumulative rate of restenosis (%) (includes stent thrombosis) Orsiro showed a lower restenosis rate than...

Highly deliverable Designed for challenging cases, the Orsiro stent system provides better push and easier cross with a lower crossing profile. Better push Transmitting up to 57%13 more force from 14 hub to tip. Orsiro BIOTRONIK Resolute Onyx Medtronic better push Xience Xpedition Abbott Synergy Boston Scientific 0 Easier cross Up to 68% less force needed to successfully cross demanding anatomies. 15,16 Orsiro BIOTRONIK Xience Xpedition Abbott less force required Synergy Boston Scientific Resolute Onyx Medtronic 0.05 Lower crossing profile Improved acute performance - up to 13% lower 15 crossing...

Orsiro BIOTRONIK Thinner struts make the difference Thinner struts create: • Less disrupted flow18 • Less arterial injury18 Synergy Boston Scientific PtCr-EES Which leads to: 18 • Improved re-endothelialization 18 • Reduced risk of restenosis and thrombosis Ultimaster Terumo The thinner the better, as long as the 18 radial force can be maintained Up to 15% more radial strength scaffolding once implanted. Orsiro BIOTRONIK Synergy Boston Scientific Resolute Onyx Medtronic CoNi-ZES Xience Family Abbott CoCr/EES more radial strength Promus Boston Scientific PtCr-EES

Vascular Intervention Coronary Indicated for discrete de novo stenotic lesions and in-stent restenotic lesions.* Technical Data Stent Stent material Passive coating Active coating Drug dose Strut thickness Delivery system Catheter type Recommended guide catheter Lesion entry profile Guide wire diameter Usable catheter length Balloon material Coating (distal shaft) Marker bands Proximal shaft diameter Distal shaft diameter Nominal pressure (NP) Rated burst pressure (RBP) Compliance Chart Nominal Pressure (NP) Rated Burst Pressure (RBP) Ordering Information Cobalt chromium, L-605 proBIO (Amorphous...