Pulsar-18
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Clinically proven Technical data/ ordering info Vascular Intervention // Peripheral BIOTRONIKSelf-Expanding Stent System/0.018'7QTW w excellence for life

140 pm thin struts - thinner than the leading brands1 Thinner struts for low Chronic Outward Force (COF)2 Stent strut thickness in perspective1 Pulsar-18 BIOTRONIK Pulsar-18 BIOTRONIK Zilver Flex Cook Medical Innova Boston Scientific EverFlex Entrust Medtronic Lifestent XL BARD Zilver Flex Cook Medical Thinner struts and lower COF make a difference:* • Lower risk of restenosis3 • Reduced vessel injury and inflammation4 • Faster endothelialization5 *As demonstrated in pre-clinical studies Innova Boston Scientific T _l_ 213 pm EverFlex Entrust Medtronic Pulsar Stent BIOTRONIK Low COF

Clinically provenLong term safety and efficacy (12 month data) 4F INTERVENTIONS 4EVER7 ** FTLR - Freedom from Target Lesion Revascularization; +PP - Primary Patency; ++A.L.L. - Average Lesion Length (Courtesy of Prof. van den Berg) BIOFLEX PEACE Pulsar-18 (BIOTRONIK)10 RESILIENT Lifestent (Bard)11 SUPERB Supera (Abbott)12 SuperNOVA Innova (Boston Scientific)13 Zilver PTX Zilver Flex Arm* (Cook Medical)14 Durability Protege EverFlex (Medtronic)15 Results from different trials are not directly comparable. Differences in outcomes may be the result of differences in protocol design, patient...

0 Stent designed for SFA* Multi-directional flexibility to conform to the natural vessel movement. ^Superficial Femoral Artery Low axial stiffness for high flexibility16 Supera Abbott Pulsar-18 BIOTRONIK Lifestent XL BARD Innova Boston Scientific EverFlex Entrust Medtronic Zilver Flex Cook Medical Bending Peak-to-valley design and S-articulating connecting bars provide multi-directional flexibility and avoid fish scaling in mobile vessel architecture.17

smaller puncture site area than 6F18 4F Low Profile - Improved 7 acute outcomes vs. 6F Potential for safer, faster and simpler procedures than 6F • Clinically proven lower access site complication rates7 • Shorter compression time • 45% smaller puncture site area than 6F • No need for a closure device Stent deployment One-handed stent release handle, ergonomically designed for a comfortable and stable handling.

Pulsar-18 Indicated for use in patients with atherosclerotic disease of the femoral and infrapopliteal arteries and for the treatment of insufficient results after percutaneous transluminal angioplasty.* Vascular Intervention Peripheral Technical Data Stent Recommended guide wire 0.018” Stent material Nitinol Stent coating proBIO (Amorphous Silicon Carbide) Stent Markers 6 gold markers each end Proximal shaft 3.6F, hydrophobic coating Stent Ordering Information 0 (mm) Catheter length 90 cm (Stent length mm) **8 weeks pre-order only 1. 6.0 mm diameters. BIOTRONIK data on file; 2. 6.0 mm...