ENHANCED PLANNING AND TREATMENT POWER WITH ELEMENTS AND LEKSELL GAMMAPLAN ™

DICOMviewer for streamlined access to patient datasets VIEWER Advanced 3D • Fast, easy access to medical image data • Quick, direct interaction with DICOM images • Simplified user interface supporting multi-touch gestures • Short learning curve and intuitive usab

SMARTBRUSH outlining Intelligent software-assisted tumor ® • Immediate, interactive target delineation • Streamlined, multi-planar volume • Smart contour expansion • Simultaneous, multi-modality consideration in out

IMAGE FUSION definition and contouring Dataset correlation for indispensable • Fully automated, highly accurate image fusion • Mutual information algorithm for dataset correlation • ROI definition on areas of similar anatomy • Contour flexibility for any dat

FIBERTRACKING Functional preservation through identification of defined neuronal connectivity • Isolation of fibers via multiple region definition • Quick visualization of functional information • Minimal fiber length definition via signal/ noise thresholding • Tractography as natural malignancy progression predictor Work in progress. Not commercially avail

LEKSELL GAMMAPLAN SRS Straightforward dose optimization with proven clinical experience ® • Fast inverse planning utilizing full automation and flexibility • Precise treatment planning and easy handling of multiple lesions • Optimized dose sculpting for Leksell Gamma Knife® SRS • Heterogeneity correction for targets near air cavities and bone with conv

LEKSELL GAMMA KNIFE

PRE-OPERATIVE EVALUATION Evaluation of optimal tumor resection and adjuvant radiosurgery/radiotherapy Benign Meningioma cf-SRT hf-SRS V (Auto) Lens, Left V (Auto) Lens, Right V (Aiitn) Optic Nerve, I eft V (Auto) Optic Nerve, Right DEMO, Schwannoma UCSF Scroll Zoom Automatic visualization of critical structures Instant, simultaneous planning of three radiation plans Tumor board discussion support and enrichment Work in progress. Not commercially available.

RESECTION EVALUATION Simulation of adjuvant SRS/SRT of residual tumor Benign Meningioma cf-SRT hf-SRS br-SRS V (Auto) Optic Tract, Right V (Auto) Hippocampus, Kight V (Auto) Cochlea, Left V (Auto) Cochlea, Right V (Auto) Lens, Left V [Auto) Lens, Right V (Auto) Optic Nerve, Left V (Autn) Optic Nerve, Right V (Auto) Optic Tract, Left Ignored Ignored Detailed toxicity table for OAR Customized pre-operative resection simulation Immediate radiation plan update Work in progress. Not commercially available.

INTRAOPERATIVEplanning CONTROL Integrated surgery and radiosurgery • Fully integrated with Brainlab cranial navigation software • Elastic integration of intraoperative data • Intraoperative surface point collection with navigation instruments • Control point exporting for post-surgical evaluation Work in progress. Not commercially avail

PLAN updated during surgery in the O.R. ADAPTATION Timely plan • Ideal sub-total resection quantification • Comprehensive visualization of plan results • May minimize surgical side effects • May enhance radiosurgical effectiveness Work in progress. Not commercially avail

Straightforward dose optimization with proven clinical experience Tools Plan Workspace Help "|Uoe Hlan: HlanA, IMP 10 Precise treatment planning Heterogeneity correction Fully automated, fast inverse planning Work in progress. Not commercially available.

© Copyright 2014 Brainlab AG. All rights reserved. RT_BR_EN_iPlanGammaPlanAHS_Oct13_Rev2 ® Registered trademark of Brainlab AG in Germany and/or the US. ™Trademark of Brainlab AG in Germany and/or the US. ® Leksell Gamma Knife and Leksell GammaPlan are registered trademarks of the Elekra grou