Do you still count cardiomyocyte beating visually? Just place a culture plate without processing Real-time automatic detection for multiwell plate Any manufacturer's culture plate can be used. Cardio Intrinsic Optical Signal Acquisition System CIOS8 To Save Time, and Reduce Cost and Work Just place a culture plate on this instrument! Activity of cardiomyocytes in a culture plate can be measured without staining and invasion. Result is displayed in real time in a waveform, and number of beats and contraction time are automatically detected with a single button. Built-in temperature control and plate moving mechanism. It is small and lightweight making it ideal for personal use. Easy operation STEP 1 Launch Software Click Button Click Button Start Measurement Detect Number of Heart Beats Automatically Data Example Measurement results of cultured cardiomyocytes ・ Count of number of beats of cultured cardiomyocytes ・ Confirmation of differentiation of iPS-derived cardiomyocytes ・ Evaluation of cardiotoxicity of new drug candidates ・ Simple measurement of membrane potential using voltage-sensitiv

Method and principle of Measurement The principle of measurement of activities is quite simple. It is well known that cell activities change light scattering, and beating cardiomyocytes show larger changes by beating activities. LED under cultureware illuminates sample at low angle. The scattered light reflected from cells is detected by photo-diode, then only change component is amplified and extracted as activity signal. The extracted signal is digitized and amplified thousands of times, or tens of thousands of times. Then, cardiac activities are recognized by numeral process. Structure of...