Belzer UW® Cold Storage Solution and ViaSpan

Product catalog summary

Overview: This document provides a comparison of the ingredients and specifications for Belzer UW® Cold Storage Solution and ViaSpan, both used for organ preservation. The key components and their concentrations are listed for each solution.

Specifications:

Hydroxyethyl starch (Pentafraction): 50.0 g/L for both solutions, concentration not applicable (NA).
Lactobionic Acid (as Lactone): 35.83 g/L, 105 mmol/L for both solutions.
Potassium dihydrogen phosphate: 3.4 g/L, 25 mmol/L for Belzer UW; Potassium phosphate monobasic for ViaSpan.
Magnesium sulfate heptahydrate: 1.23 g/L, 5 mmol/L for both solutions.
Raffinose pentahydrate: 17.83 g/L, 30 mmol/L for both solutions.
Adenosine: 1.34 g/L, 5 mmol/L for both solutions.
Allopurinol: 0.136 g/L, 1 mmol/L for both solutions.
Total Glutathione: 0.922 g/L, 3 mmol/L for both solutions.
Potassium hydroxide: 5.61 g/L for Belzer UW and 14.5 g/L for ViaSpan, both with 100 mmol/L due to different concentrations used.
pH Adjustment: Sodium hydroxide/Hydrochloric acid used to adjust to pH 7.4 for both solutions.
Water for injection: Quantity sufficient (q.s.) for both solutions.

Procedures and Recommendations:

Belzer UW® Cold Storage Solution does not require filtering before use or refrigerated routine storage.
The solution must be cooled to 2° to 6°C (36° to 43°F) prior to use.

Catalog excerpts

Belzer UW® Cold Storage Solution and ViaSpan-1

Belzer UW® Cold Storage Solution and ViaSpan Belzer UW® Cold Storage Solution Ingredient Hydroxyethyl starch (Pentafraction) Hydroxyethyl starch (Pentafraction) Lactobionic Acid (as Lactone) Lactobionic Acid (as Lactone) Potassium dihydrogen phosphate Potassium phosphate monobasic Magnesium sulfate heptahydrate Magnesium sulfate heptahydrate Raffinose pentahydrate Raffinose pentahydrate Total Glutathione Total Glutathione Potassium hydroxide* Sodium hydroxide/Hydrochloric acid (adjust to pH 7.4) Sodium hydroxide/Hydrochloric acid (adjust to pH 7.4) * Please note that while the g/L of potassium hydroxide for ViaSpan vs Belzer UW is different, the mmol/L is the same. This is due to the difference in concentration of potassium hydroxide used. Belzer UW® Cold Storage Solution does not require filtering before use or refrigerated routine storage. However, please note that the solution must be cooled to 2° to 6°C (36° to 43°F) prior to

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