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NanoBrook 173Plus

Product catalog summary

Overview
The NanoBrook 173Plus is a sophisticated instrument designed for the characterization of proteins, antibodies, nanoparticles, and other small molecules. It employs backscattering detection for high sensitivity and accuracy, particularly for particles less than a few tens of nanometers.

Key Features

Backscattering detection at 173° for enhanced sensitivity and reproducibility, especially for samples under 50 nm.
Rapid and accurate size distribution measurements for proteins and nanoparticles.
Capability to measure protein molecular weight and polymer size.
Compliant with ISO 13321 and ISO 22412 standards.
Dynamic light scattering at both 173° and 90° angles.
Temperature control ranging from -5 °C to 110 °C.
Compact design with USB connectivity.

Specifications

Sample Types: Suitable for most globular proteins, nanoparticles, and small polymers in non-absorbing liquids.
Sample Cells: Options include 50 µL disposable and 1 to 3 mL disposable plastic, glass, or quartz cells.
Concentration Range: 0.1 ppm to 50 mg/mL, depending on refractive index and concentration.
Signal Processing: Utilizes Dynamic Light Scattering (DLS) with Brookhaven’s TurboCorr correlator.
Precision Sizing: ± 1% typical.
Standard Laser: 35 mW red diode laser with a nominal 640 nm wavelength.
Power Requirements: 100/115/220/240 VAC, 50/60 Hz, 150 Watts.
Dimensions: 23.3 x 42.7 x 48.1 cm (HWD).
Weight: 15 kg.
Environmental Characteristics: Operates in temperatures from 10 °C to 75 °C and humidity from 0% to 95%, non-condensing.

Principles of Operation
The NanoBrook 173Plus operates on the principles of Dynamic Light Scattering (DLS) for particle sizing and distribution. It is capable of handling dilute suspensions and provides quick measurements with high accuracy.

Data Analysis
The instrument offers various data analysis options, including lognormal distribution by intensity, volume, surface, and number, as well as full size distribution (MSD) by the same factors.

Contact Information
Brookhaven Instruments Corporation, 750 Blue Point Road, Holtsville, NY 11742-1832 USA. Email: [email protected]. Website: www.BrookhavenInstruments.com. Telephone: +1 631.758.3200. Fax: +1 631.758.3255.

Catalog excerpts

NanoBrook 173Plus Protein & Nanoparticle Sizer Protein Sizing Polymer Sizing Nanoparticle Sizing

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Protein & Nanoparticle Sizer • Rapid and accurate protein & nanoparticle size distributions • Protein molecular weight • Polymer size & molecular weight • Multimodal & unimodal size distribution software • Customizable reports • High power 35 mW diode laser • Dynamic light scattering at 173° and 90° • Compact bench top unit, USB connection Brookhaven's' NanoBrook 173Plus instrument is the go-to-solution for characterization of proteins, antibodies, nanoparticles, macromolecular assemblies and other molecules/particles of small sizes. The NanoBrook 173Plus uses backscattering detection for the...

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Data Presentation The NanoBrook 173Plus particle size analyzer offers many choices for data analysis. One choice is the lognormal distribution by: intensity, volume, surface and number. Another choice, the full size distribution (MSD) can be displayed by the same four weighting factors. In the example above, the MSD is presented by volume for lysozyme. The size distribution and cumulative distribution are shown in the table on the right. Lysozyme has a very low polydispersity in this case. Accurate and Reliable The new NanoBrook 173Plus particle size analyzer incorporates all you need for fast,...

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Protein & Nanoparticle Sizer 750 Blue Point Road Telephone: +1 631.758.3200 |k | NOVA

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NanoBrook 173Plus

NanoBrook 173Plus

Catalog excerpts

All Brookhaven Instruments Corporation catalogs and technical brochures