Bruker ToxScreener A Comprehensive Screening Solution for Forensic Toxicology Innovation with Integrity

ToxScreener Get the Complete Picture Forensic laboratories are frequently required to perform comprehensive screening of complex samples to identify drugs and other toxicants. This is a very challenging task due to the enormous number of analytes covered, their wide range of concentration and the complexity of sample matrices tested. Within the field of forensic toxicology, there is high requirement for analytical certainty in the accuracy and completeness of the results, so as to ensure that they will stand up to scrutiny in a court of law. In recent years, owing to the high level of specificity...

ToxScreener Workflow Prior to analysis, depending on the analytical requirements, blood serum or urine samples are prepared using LLE, SPE or protein precipitation. They are then injected onto a reverse phase binary gradient UHPLC- QTOF system for mass selective detection and confirmation. The Bruker ToxScreener combines broadband CID (bbCID) QTOF data acquisition with the ToxScreener accurate mass forensic database and associated data mining software to bring the full power of exact mass screening to the forensic laboratory. Sample Blood, Urine Human tissue SPE, PPT, LLE LC-QTOF UHPLC + Bruker...

Broadband CID (bbCID) Data Acquisition During the entire chromatographic separation step, the QTOF mass spectrometer rapidly and continuously cycles between TOF-MS and bbCID MS/MS resulting in the seamless collection of a comprehensive catalogue of precursor and fragment ion data in a single analysis. The ability of QTOF instrumentation to collect 'all of the ions, all of the time' in both MS and MS/MS full scan modes results in a dataset that is complete and unrestricted. Once collected, the analyst can perform detailed targeted and / or non-targeted investigations if desired. Collison cell...

b) bbCID spectra, Qualifier Ions circled in green Fig.3: a) Chromatographic overlay of bbCID Qualifier (QI) Ion traces Fig.4: broadbandCID (bbCID) data acquisition differentiating two isomeric synthetic cannabinoids, JWH-122 and JWH-019. Their unique bbCID qualifier ions (highlighted in the green boxes) are used for unambiguous identification

Ordering Information ToxScreener Applications kit: Part number 1827630 *Contact your local sales representative for a list of current compatible instruments. For research use only. Not for use in diagnostic procedures. Bruker Daltonik GmbH Bremen · Germany Phone +49 (0)421-2205-0 Fax +49 (0)421-2205-103 [email protected] Billerica, MA · USA Phone +1 (978) 663-3660 Fax +1 (978) 667-5993 [email protected] to change specifications without notice. © BDAL 10-2014, 1832909 Using accurate mass measurement, the ToxScreener forensic toxicology database allows you to screen and identify over 1,600 target analytes...