MASS SPECTROMETRY Product Overview Life Science Mass Spectrometry Innovation with Integrity

Driving Innovation in Proteomics, Metabolomics, Pharma/Biopharma and other fast-growing Fields of Life Sciences Bruker is enabling scientists to make breakthrough post-genomic discoveries and develop new applications that improve the quality of human life. Bruker’s high performance scientific instruments and high value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular, and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity, and customer success in post-genomic life science molecular...

Life Sciences Premier Provider of High-Performance Scientific Instruments and Life Science Research and Diagnostic Solutions ■ Since 1960 track record of technological pioneering ■ Culture of disciplined entrepreneurship ■ Extensive collaborations with renowned science labs ■ Deep chemistry, biology and physics applications expertise Market Leader in High-Performance Scientific Instruments Employees Patents pending Bruker holds #1 or #2 market positions in 70% of our portfolio.

Trapped Ion Mobility Mass Spectrometry timsTOF - The next generation ion mobility separation Bruker's timsTOF instruments revolutionized mass spectrometry by unlocking an additional dimension of separation with high sensitivity and speed. Trapped ion mobility increases peak capacity and confidence in compound characterization. Whether you need a reliable workhorse, a high-throughput powerhouse, a single-cell specialist, an ultra-sensitive flagship instrument, or a MALDI-guided SpatialOMx® expert there is the right timsTOF for your research needs. PASEF® (Parallel Accumulation Serial Fragmentation)...

timsTOF fleX Solutions: MALDI-2 Technology — Bringing enhanced depth and sensitivity The MALDI-2 post-ionization boosts sensitivity by up to 2-3 orders of magnitude compared to traditional MALDI, depending on sample, matrix and analyte. This technique enables access to a wider range of chemical classes by reducing ion suppression effects. MALDI-2 is fully integrated in Bruker's software solutions and switching between ESI, MALDI and MALDI-2 is only one click away. microGRID — A powerful MALDI stage technology for accurate and robust high resolution imaging Bruker’s microGRID technology combines...

For over 30 years, matrix assisted fisgifldpsorption ionization (MALDI) TOF MS has proven its analytical capability. Offering unparalleledspeed (time to results) and flexibility, MALDI-TOF MS stands out for its low sample volume requirem§ti&‘and ability to handle a broad rongefsalMpecontent, including salts and buffers. Discover the neofleX™ MALDI-TOF/ TOF, a high-performance benchtop mass spectrometer designed for speed and flexibility. With smart-beam 3D laser, it supports multio-mics, offering robust imaging and analysis. The rapifleX® MALDI-TOF/TOF system features a 10 kHz smart-beam 3D laser,...

MALDI Solutions rapifleX MALDI PhamaPulse The rapifleX MALDI PharmaPulse (MPP) enhances label-free HTS, combining the mass detection of enzymes, substrates and products with the required speed to comb through compound libraries containing millions of substances. The use of mass spectrometry allows the measurement of unmodified substrates in primary screens, greatly reducing false positive rates, and minimizes compounds sent to confirmation screens. The system is designed for automatic handling of 1536 well sample plates to screen more than a million compounds in a week in support of drug discovery....

Magnetic Resonance Mass Spectrometry Unravel nature’s secrets The analytical fields of MALDI Imaging, intact biomolecules and metabolomics share the requirement for absolute certainty in compound identification. There can be no margin of error in the detection and correct assignment of extremely dangerous byproducts or deadly drug metabolites. With Bruker's MRMS technology, resolution and mass accuracy over a wide mass range reach unrivaled incredible new heights. scimaX MRMS Bruker’s revolutionary superconducting magnet technology is the basis of the smaller footprint scimaXR MRMS system. This...

Surface Plasmon Resonance High performance, high-throughput SPR Analytical Biosensor for the real-time, label-free characterization of molecular interactions Surface plasmon resonance is an optical-based, label-free detection technology for real-time monitoring of binding interactions between two or more molecules. A wide range of molecules can be studied, from fragments to small molecules to proteins and viruses. This innovative technology is capable of providing biophysical data such as affinity, kinetics and thermodynamics, in addition to answering basic questions of binding specificity and...

Ultra-High Resolution' QTOF Mass Spectrometry *, * ‘ ■ + 1 ■ . i Obtaining the most complete and true picture of a sample set is a consistent goal. Complex sample matrices demand ever higher levels of sensitivity and speed to truly advance scientific knowledge. However, there are everyday practical realities that are required to be routinely-overcome. The outstanding dynamic range, high mass accuracy, and MS/MS performance enable Bruker's UHR QTOF MS- systems to deliver confident, reliable results for both targeted . analytical testing and broader discovery research applications.

ESI QTOF Our ESI QTOF mass spectrometers are the showcase instrument platform for life science research, drug discovery and development, and screening applications involving the analysis of both targeted and unknown compounds in complex matrices. The systems provide cutting edge performance in one-shot analysis for identification and quantitation from small molecules up to high MW antibodies, and the dynamic source configuration offers significant analytical versatility. resolution: 30,000 scan speed: fragmentation: source: size [mm]: scan speed: fragmentation: maXis II resolution: 80,000 scan...