Metabolomics • Novel solutions for Metabolomics and high-throughput Phenomics Innovation with Integrity

Powerful Yet Intuitive The metabolome is the final manifestation of biochemical pathways. It shows an extremely large variety of structural classes as it includes the complete set of metabolites of all cellular processes. Changes in the metabolite composition reflect the outcome (phenotype) of interactions at the genomic, transcriptomic and proteomic levels. Therefore, studying the phenome is a cornerstone to gain deeper insights related to e.g. diseases, therapeutic interventions or environmental influences. MetaboScape helps to find regulated biomarkers in the global profiling of large sample...

Confidently venture into the unknown Metabolomics and high throughput Phenomics Flow Injection Analysis - MRMS provides high sample throughput for phenomics research with ~5 min cycle time per sample (including both polarities) - more than a factor of 10x faster than conventional LC-MS methods. FIA-MRMS can generate thousands of molecular formulae for metabolites in every sample and reveals additional compounds not detectable via LC-MS. The Phenomics Workhorse Complementary deep metabolomics by UHPLC-QTOF-MS/MS can ‘detect’ thousands of features and identify hundreds of metabolites by combining...

How robust is your data quality over a sequence of several weeks? – The “phenomics workhorse” Achieving a high data quality is mandatory for complex profiling experiments. Large batches of samples frequently bring along an increasing build-up of contamination. The larger the batch, the more important a steady data quality becomes for subsequent statistical calculations. The impact II offers outstanding robustness and excellent long-term stability for long sample sequences typical of large cohort studies, making it truly a phenomics workhorse. Figure 1 shows the development of data quality over...

Simplified T-ReX LC-QTOF solution for non-targeted Metabolomics Confidently identifying compounds relevant for metabolic processes relies on several crucial steps, including sample preparation, data acquisition, data pre-processing and data evaluation. In order to simplify and harmonize this workflow, Bruker developed the T-ReX LC-QTOF solution. The complete solution (Part no. 1859587) includes: • Standard Operating Procedures (SOPs) for the preparation of typical clinical research samples, e.g., urine and plasma • ELUTE UHPLC for analyzing large sample cohorts with high retention time stability...

Achieve high sample throughput with MRMS aXelerate ... T-ReX 2D Feature extraction LC free MRMS measurements with sub-ppm mass accuracy Feature Matrix incl. Isotopic Patterns and Isotopic Fine Structure Unique Molecular Formulae Annotation incl. Annotation Quality Scoring Targeted Analyte List Determine Compounds of Interest Putative Structure Annotations Perfect for Metabolomics, Phenomics or any other large-scale sample evaluation: MRMS aXelerate is basedbases on the extreme resolving power of the scimaX MRMS system and uses MetaboScape 4.0 to enable a powerful chromatography-free solution....

Non-targeted profiling Benefit from all of the advantages of the Bruker LC-/GC-QTOF Metabolomics solution: • Simplified high quality data acquisition thanks to outstanding instrument robustness, Full Sensitivity Resolution, high dynamic range, and ready-to-use InstantExpertise™ methods. • Comprehensive data evaluation in MetaboScape. Make the most of your data via fully automatic and confident ID of known metabolites, supporting Bruker HMDB and MetaboBASE as well as personal MS/MS libraries. Seamlessly annotate unknown analytes via automated formula generation and MetFrag in silico fragmentation....

Look Out! MetaboScape will provide deeper insights and simplify your metabolomics data processing The “Phenomics workhorse”: the impact II LC-QTOF provides outstanding robustness for large cohort studies For research use only. Not for use in diagnostic procedures. Bruker Daltonik GmbH Bremen · Germany Phone +49 (0)421-2205-0 Fax +49 (0)421-2205-103 [email protected] - www.bruker.com to change specifications without notice. © BDAL 05-2017, 1859785 scimaX MRMS aXelerate enables the measurement of > 200 samples per day with chromatography-free acquisitions for large-scale profiling studies...