Toxtyper • Confident and Comprehensive Screening with Simplicity and Speed Innovation with Integri

Today's forensic toxicology and clinical research labs are challenged by demands for fast and accurate results, along with lab efficiency and cost reduction. Further pressure results from the continuous emergence of new drugs into the market, requiring frequent updates of sample screening methods. Easy to use, flexible, and reliable screening and analysis techniques are clearly needed to address these demands. The Toxtyper is a toxicology "push button solution" with ready to use LC-MS n methods and a simplified, intuitive user interface for immediate use - providing full confidence in every laboratory...

High confidence identifications Simplicity, speed and confidence by true MSn Rapid and reliable detection of drugs and potential toxins is critical in clinical research screening and forensic applications. The Toxtyper system identifies compounds based on retention time, MS, MS2 and (if necessary) MS3 information, minimizing data evaluation time and quickly delivering dependable results. As modern developments in drug research and the abuse of new psychoactive substances continuously alter the analytical landscape for toxic chemical screening demands, identification by true MSn provides analytical...

Easy access to high-value data Within the dynamic Toxtyper 2.0 user interface, the Result Review panels may be customized to the users' preference. Identified compounds can be sorted by various parameters, e.g. by peak intensity, retention time or alphabetically. Color coding of deviating parameters in retention time or mass shift, or of lower purity scores, supports the easy result evaluation. Peak and spectra assessment are readily made within the Chromatogram List and Mass Spectra List with "point and click” and zooming features. Identified Compounds dRT[mw>] d rrvj |D»] Punt/ InUnady P

Open toxicology concept Keep your screening and research workflows up-to-date The appearance of new drugs, such as synthetic cannabinoids, makes it necessary to update your screening methods quickly. Toxtyper provides a ready-to-use spectral reference library of more than 980 compounds and metabolites, constantly updated through contributions from our customers Add new compounds in only a few mouse clicks 1 and collaboration partners. User-defined library entries can be created in a few mouse clicks, allowing your laboratory to quickly respond to new patterns of illicit and licit drug misuse....

Data-dependent acquisition using Bruker's patented SmartFrag™ technology facilitates the rapid analysis of different types of compounds in every sample, irrespective of concentration, complexity or sample matrix. With this technology, your spectra and your results are completely transferable and reproducible. The Toxtyper's patented Dual Ion Funnel provides high sensitivity, with detection in the low ng/ml range. Using Zero Delay Alternating (ZDATM) polarity switching, both basic and acidic drugs can be rapidly targeted in one analysis to provide a full MS picture. Amitriptyline: MS2 results...

Comprehensive screening methods reveal qualitative results. However, positive findings may make it necessary to obtain detailed quantitation or an approximate value for a specific compound in a given sample. For added screening value, the standard Toxtyper analyses can be extended using included automated methods for semi-quantification using the Toxtyper 2.0 / 2.0-E library or the DOA library. By performing a one-point calibration for the target compounds using two or more internal standards prior to the Toxtyper analysis, data regarding the concentration range (e.g. above or below a target...

A complete toxicology solution Dr. Michael Böttcher, Head of Toxicology MVZ Labor Dessau GmbH “The Toxtyper is our fast routine workhorse solution for General Unknown Screening (GUS) in diverse matrices such as blood, urine or gastric content. We answer demanding questions for our addictions lab customers by new Toxtyper applications like GUS in saliva.“ Benefits of using Toxtyper: "Streamlined sample throughput in our laboratory by unified, faster and easier sample preparation for urine samples and 24/7 usage of the system. Ready to use methods combined with comprehensive libraries." George...