1. Catalogs
  2. Bruker Nano Surfaces
  3. MALDI PharmaPulse HTS

MALDI PharmaPulse HTS

MALDI PharmaPulse HTS

MALDI PharmaPulse HTS

Product catalog summary
Overview
The document describes the MALDI PharmaPulse, a mass spectrometry-based screening solution designed to accelerate drug discovery. It highlights the system's capabilities for high throughput screening (HTS) with true label-free detection and ultrafast analysis times.

Specifications and Features
  • True label-free detection of native substrates and products in biochemical assays.
  • Fastest MS-based screening system with cycle times between 0.5 and 1 second per sample.
  • Significant reduction in solvent and reagent usage, leading to lower costs per analysis.
  • Simple and rapid assay development without the need for SPE or HPLC sample pre-treatment.
  • Capability to screen over 50,000 samples per day with robust automation and workflows.

Plate Reading Capabilities
The system is based on Bruker's FLEX series MALDI-TOF mass spectrometers, offering 96, 384, and 1536 plate reading capabilities. A complete 1536 target plate can be analyzed in less than 25 minutes.

Automation and Software
  • Fully automated data acquisition and processing with Bruker's Compass software.
  • Flexible data output formatting for easy transfer to other software systems.
  • High precision robotic arm and liquid handling systems for plate management.
  • Cellario dynamic scheduling software for seamless control of automation and MALDI-TOF components.

Cost Efficiency
  • Up to 100 times less solvent usage compared to multi-plexed LC/SPE-MS systems.
  • No need for SPE cartridges or HPLC columns.
  • Extremely low sample volumes required for detection, enabling single well kinetic readouts.

Customization and Support
Customized automation packages are available to meet unique screening needs. Further reading on assay development for MALDI-TOF mass spectrometry is available in Bruker's application notes.

Contact Information
Bruker Daltonik GmbH, Bremen, Germany and Bruker Daltonics Inc., Billerica, MA, USA. Contact details are provided for further inquiries.
See more

Catalog excerpts

MALDI PharmaPulse HTS-1

MALDI PharmaPulse™ Accelerating Drug Screening and Discovery Innovation with Integrity

 Open the catalog to page 1
MALDI PharmaPulse HTS-2

MALDI PharmaPulse – The Fastest MS System for Biochemical Screening MALDI PharmaPulse is a complete mass spectrometry based screening solution designed to accelerate all phases of drug discovery. The system offers the advantage of true label-free detection of native substrates and products in functional biochemical assays. An ultrafast MALDI-TOF system delivers analytical results in less than 1 second per sample making it uniquely suited for High Throughput Screening (HTS) applications. This innovative solution delivers significant cost-persample reductions due to the extremely low solvent and...

 Open the catalog to page 2
MALDI PharmaPulse HTS-3

Plate Reading with MALDI-TOF MS Based on Bruker‘s market leading FLEX series matrix assisted laser desorption ionization time of flight mass spectrometers (MALDI-TOF), the MALDI PharmaPulse provides true MS based 96, 384 and 1536 plate reading capabilities. The analysis of a complete 1536 target plate takes less than 25 minutes. Subsequent target plates are automatically exchanged with the included automation package or with custom solutions. All of Bruker‘s MALDI-TOF systems incorporate patented smartbeam™ laser technology for unrivalled speed, sensitivity, and resolution. Bruker’s flagship...

 Open the catalog to page 3
MALDI PharmaPulse HTS-4

Fully Automated Plate Management, Preparation and Loading The MALDI PharmaPulse features a full automation package from HighRes Biosolutions that seamlessly prepares and loads MALDI plates into the FLEX series MALDI-TOF system. Major components of the pre-configured system includes: • A high precision, fully articulated robotic arm that manages all plate movement • A configurable plate carousel that can hold up to 172 plates • A high precision liquid handling and pipetting robot compatible with 1536, 384 and 96 formats • A high-speed delidding hotel that does not require house vacuum Customized...

 Open the catalog to page 4
*Prices are pre-tax. They exclude delivery charges and customs duties and do not include additional charges for installation or activation options. Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates.