INFRARED LASER IMAGING MICROSCOPY Light Speed for Chemical Imaging. Innovation with Integrity

Infrared Laser Imaging (ILIM) is a fundamentally different measurement approach compared to FT-IR imaging. Once the key differences become clear, it is easy to grasp the extensive benefits of this new technology - and take advantage of them. Left: Schematic emission profile of a thermal source. Right: Tunable emission of a QCL. Wavelength Traditional FT-IR microscopy and imaging rely on a thermal source, that emits with low intensity across a broad spectral range (Fig.1, left), allowing the measurement of the full wavenumber range at once. The relatively low intensity requires very sensitive...

But why is IR imaging so powerful? And why is speed of acquisition such an important factor? The following example illustrates both. In cancer research, thin sections of biological tissue are examined to detect diseased cells and study cancer progression. Visual microscopy (Fig.2, left) does not provide sufficient contrast and requires the tissue to be treated with staining agents prior to inspection. In contrast, IR imaging delivers the neccessary chemical information for cancer detection without any staining or labeling (Fig.2, right). Fig. 2 A visual image (left) provides general information...

Fig. 3 Comparison of field of view of LUMOS II in FT-IR imaging (left) and ILIM (right). To put it in numbers: the ILIM offers two orders of magnitude increase in speed and field of view, when compared to traditional FT-IR imaging (Fig. 3). The reason lies within the unique combination of radiation source and detector: The high intensity of a QCL allows to illuminate a very large area simultaneously The widefield IR bolometer camera provides an extremely large field of view This way, ultra-high measurement speed is achieved. Usually, this speed increase comes at a price, as a laser is a coherent...

Infrared laser imaging (ILIM) is an incredible opportunity to develop new applications in any field where FT-IR FPA imaging seemed to slow. With the HYPERION II, you are perfectly prepared to give definite answers to complex analytical questions and new discoveries, powered by the ultimate versatility of FT-IR and ILIM in one device. But for some applications, ILIM has already proven as a robust method that delivered extraordinary results.[1,2,3] For those applications, we built the LUMOS II as an honest, straightforward ILIM workhorse. Our ApplicationPlus™ ensure seamless and easy operation...

Dedicated Workflow. Faster Results.  Sampling & Acquisition Follow robust and automated acquisition methods to acquire reproducible ILIM data at scale. Evaluation Use our AI driven algorithms or develop your own analysis pipelines to process and visualize your data.  Results & Reporting Generate "teaching images" for seamless interfacing with other imaging modalities. Create high-quality figures for publications. This example using a tissue sample illustrates one thing above all: ILIM is a complete solution for every application it supports: tissue, tablet and particle analysis. Hardware and...

TissuePlus™ This workflow offers a complete toolset for high throughput tissue analysis. Dedicated sample holders facilitate transmission or reflection measurements, the workflow ensures a maximum automation and easy operation. TissuePlusTM includes batch-processing for multiple samples on the same slide and allows interfacing to other analysis methods (e.g. MALDI) in multimodal studies. TabletPlus™ This workflow provides a convenient platform for routine imaging of pharmaceutical tablets. The sample holders are tailored for a streamlined, reproducible analysis. Use smart software to setup product-specific,...

Pioneers Need the Best Support Our software? Mighty simply. We follow a simple philosophy in our hardware design. We believe that high-quality automation is the best way to achieve maximum robustness, reliability, and ease-of-use. OPUS can be perfectly tailored to your needs and features classical as well as AI-based evaluation tools to speed up analysis of any sample you might encounter. Our instruments feature extensive system intelligence and self-tests to assure highest performance and ease of operation. Together with customer-centric service solutions, your system never lets you down. Our...