ORAL surgery
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Endogenous Regenerative Technology oral surgery

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LEADER IN REGENERATIVE MEDICINE BTI Biotechnology Institute is a Spanish biomedicine company focused on the development of translational research projects (R&D+i). BTI is a world-level scientific leader in regenerative medicine using Endoret in different fields of medicine. MORE THAN 5000 M2 DEVOTED TO TRAINING, CLINICAL PRACTICE AND RESEARCH We train in order to optimise the clinical results Specific training aimed at different medical specialisations. More than 40 scientific collaboration agreements with universities and research institutes all over the world. More than 1200 students per...

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endoret® technology ORAL SURGERY Translational research: knowledge acquired in the Laboratory applied to clinical practice CLINICAL PRACTICE Collaboration with experts from different countries in different fields of medicine for the development of clinically effective protocols. More than 100 indexed scientific publications back the effectiveness and biosafety of Endoret® 20% of the workforce dedicated to research. More than 15 years of research in tissue regeneration.

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ENDORET® is a biomedical technology aimed at stimulating tissue regeneration by applying autologous proteins. Hundreds of endogenous proteins affect the tissue repair processes, including angiogenesis, chemotaxis and cell proliferation. No exogenic agent can effectively govern all these processes. (1) Endoret technology provides the necessary means for the isolation and concentration of the blood proteins involved in tissue regeneration, as well as its suitable application at the injury site. (2) (1) Anitua E, Sánchez M, Orive G, Andia I. Delivering growth factors for therapeutics. Trends...

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endoret® technology ORAL SURGERY active principle A. GROWTH FACTORS ENDORET stimulates tissue regeneration due to its content in growth factors, in greater concentrations than those of blood. (3) quantification of the increase in VEGF (Vascular Endothelial Growth Factor) and PDGF (Platelet Derived Growth Factor) BASELINE ENDORET VEGF pg/ml PDGF* ng/ml *(PDGF ng/ml) B. Fibrin Membrane Enables the balanced and gradual release of a large number of molecules, including growth factors and other proteins.(4) (5)

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ORAL SURGERY endoret® technology 1. Promoting angiogenesis (6) 2. Stimulating cell migration (7) 3. Increasing the proliferation (8) (9) (10) 4. Decreasing inflammation and pain(11) 5. Stimulating autocrine and paracrine secretion of growth factors (8) (9) (10) Endoret accelerates cell migration for regenerative purposes (6) Endoret technology® reduces the tissue repair time(12) (13) SCAN THE CODE WITH YOUR SMARTPHONE TO WATCH THIS VIDEO Natural wound-healing process Haemostasis Inflammation Proliferation Process accelerated with Endoret technology® Response of the tissue (Reduction in...

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endoret® technology ORAL SURGERY THERAPEUTIC FORMULATIONS With Endoret technology we can make 4 different therapeutic formulations and adapt them to the different clinical goals. (14) 3. agglutinating a graft with biomaterial Autologous product, there are no incompatibilities nor risk of rejection. All the formulations of ENDORET have a bacteriostatic effect, especially during the 4 hours after application.(15) More than 700,000 patients have been treated in more than 20 countries, without any adverse effects being reported. (9) Anitua E, Tejero R, Zalduendo MM, Orive G. Plasma Rich in...

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When the surface of the implants is wet with ENDORET liquid a fibrin membrane is formed that adheres to the surface of the implant and releases growth factors and improves the osseointegration. The nano-rough surface of BTI implants is specially designed to boost the biological effects of ENDORET. WETTING WITH ENDORET INCREASED THE TRABECULAR THICKNESS AND MATuRITY Of The BONE survival rates reported in prospective TRIALS: • 5-year follow-up study • 5787 implants. 99.2% (16) • 5-year follow-up study • 1139 immediate load implants.99.3% (17) • 8-year follow-up study • 1287 short implants....

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ORAL SURGERY 2 TREATMENT OF ALVEOLUSES POST-EXTRACTION The application of PRGF®-Endoret® in the treatment of alveoluses post-extraction reduces inflammation and pain, accelerates the epithelisation of soft tissues and promotes bone regeneration. (20) (21) (22) The survival rate of an implant placed in an alveolus post-extraction immediately is 98%, and is a safe, effective and predictable treatment. (23) * p<0.05 ENDORET CONTROL Extraction and placement of Endoret®-PRGF®. Primary closure of the alveolus after 15 days. Treatment schedules of an alveolus post-extraction Fibrin membrane Defect...

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ORAL SURGERY ENDORET® TECHNOLOGY 1$ REDUCED RiSK OF OSTEONECROSiS Treatment with ENDORET after resecting the necrotic bone increases the activity of the osteoclasts and causes angiogenesis, which can be used as an adjuvant for patients with BRONJ. (24) The results of various studies suggest that treatment with ENDorET can lessen the risk of developing BRONJ after a dental extraction in high-risk patients in treatment with bisphosphonates. (25) (26) clinical trial of the prevention of bisphosphonate-associated osteonecrosis of the jaw (BRONJ) ENDORET®-PRGF®

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endoret® technology ORAL SURGERY 4 Endoret® in the treatment of BRONJ Endoret was effective in the surgical treatment of bisphosphonate-associated osteonecrosis of the jaw, achieving closure of the defect in 32 patients in a prospective study.(27) Endoret restored the function of the inferior dental nerve affected by the BRONJ lesion. (27) ENDORET can be used to agglutinate biomaterial, making it easier to handle and improving its osteoconductive and biological properties, in both heterologous and autologous grafts. (28) (29) (30) (24) Mozzati M, Gallesio G, Arata V, Pol R, Scoletta M....

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ORAL SURGERY 6 treatment of maxillar atrophy ENDORET improves the tissue regeneration and its versatility means it can be used in various surgical techniques. a. Lateral bone increase Apical Occlusal The crestal expansion and crestal split techniques in two stages combined with ENDORET treatment can achieve an average bone expansion of 3.35 mm.(31) Distribution of width values (mm) of the initial and final crests. The use of Endoret in combination with the block graft improves the healing of the flap, avoiding the exposure of the graft and improves the post-operative outlook of the patient....

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