Immunohistochemistry
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CANCER DIAGNOSTICSINC

SUBSTRATE -CHROMOGEN MICRO ARRAY SLIDES

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Dear Laboratory Professional, Cancer Diagnostics, Inc, {CD} immunahistechemistry reference guide 2015 makes its debut with over 330 IVD antibodies including over |30 Rabbit monoclonals. Antibodies are compatible with all industry detection systems to ensure easy incorporation into existing laboratory protocols. This guide is a gateway to exceptional products manufactured to the highest [VD standards including a diverse selection of detectien systems, chromogens and IHC ancillaries. Use this guide to explore and find the right sclution for your laboratory, We make ordering easy with 100%...

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IHC Validation Guidelines and the Role of Tissue Microarrays Written By Andre Jordan Sanchez, ps.mea Edited by Dr. Alfonso Heras and Dr. Regan Fulton Background It is no secret by now that immunohistochemistry has experienced a tremendous amount of growth since its initial applications as a research tool in the | 960°s. Immunchistochemistry (IHC), is often referred to as the “gold standard” in tissue-based diagnostics IHC is so clinically accepted that since | 963, the number of publications that include the term “immunchistochemistry™ has increased 40 fold to over [22,000 1). Additionally,...

Multiple cores can be affixed to a slide, and generally vary in size from 0.6 to 7 mm in diameter quantity of cores selected for TM&'s can vary tremendously, The from as little as two to as many as hundreds of tissue cores on one slide. Tissue microarrays let a researcher, pathologist or technician improve workflow by the tasting of several cores on one slide, instead of the more traditional one sample per slide. Additionally, cell lines can also be substituted for tissues, leading to the construction of a cell line microarray. Such a microarray may prove to be useful for labs that may need...

Alpha-1-Antchymatrygpsin antibody reacts with histiocytes and histiocytic neoplasms. Hs rmajor application ls defining the presence of Alpha-1-Antdchymotrypsin In histlocyites and tumors derived from them. In eosinophilic granuloma and malignant histlocytosls, the reactlon for this marker l= heterogeneous In Intensity and distribution. In fibrous histlocytomas, under certain circumstances, a diffuse homogeneous reactlon may be observed. IHC of ACTH on an FFPE Pituitary Tissue THC of Alpha-1- Artitrypsin pre an FFPE Tomxil on an FFPE Tonsil Tivsoee Alpha-1-Antchymaotrypsin Is a glycoprotein...

Actin, Muscle-Specific Actin, Smooth-Muscle THC of Actin, Muscle-Specific on an FFPE Skeletal Muscle Tissue THC of Actin, Smooth-Muscle on an FFPE Appendic Tissue Actin Is a globular-structural, 345 kDa protein that pohmnerdzes In a hellcal fashbon to form an actin filament [or microfilament). Actin filaments provide mechanical support for the cell, movements (through lamellipodia, filopodia, or pseudopodial; and participate In certalm cell Junctions, In cytoplasmic streaming and In contraction of the cell during cytokinesis. In rmusde cells they play an essentlal role, along with myosin,...

Alpha-Fetoprotein, RMab THC of ALK-1CD246 on an FFPE Anaplastic Large Cell Lymphoma Tisyoe Anaplastic Lymphoma discovered THC of AFP on ane FFPE Yerlk-Sac Corrine Tissue Alpha-fetoproteln (AFF) Is a protein which In humans Is encoded by the AFP gene. This gene encodes alpha-fetoproteln, & major plasma proteln produced by the yolk zac and the liver during fetal life. This protein Is thowght to be the fetal counterpart of serum alburnin, and the alpha-fetoproteln and albumin genes are present In tandern on chromosome 4, same 5 (2:5), the ALK gene fuses with the MPM gene. The chimeric product...

THC of AMACR on an FFPE Prostatic IAC of Androgen Recepior on an FFPE Prosiute Tissue Adenecarcinome Tivsue AMACR (P5045) kB an acronym for the protein alpha-methylacyd CoA racemase that helps to metabolize certain fatty adds within the body AMACR has been recently described as a prostate cancer-specific gene that encodes & protein Involved In the beta-oxidation of branched chain fatty acids. Expression of AMACR protein Is found In Prostatic Adenocardnoma but mot In benlgn prostatic tissue It stalns premalignant lestons of the prostate: High-Grade Prostatic Intreepltellal Hyperplasia....

THC of Box em an FFPE Hodgkin's Lymphoma Tissue THC of Arginese-1 on an FFPE Hepatocellular Carcinoma Tissue Argimase Is the catalyst for the fifth and final step In the urea cycle, which ls a series of blochemical reactions In mammals during which the body disposes of harmful ammonia. Arginase works tr convert L-arginine Into L-ornlthine and urea. Argmase-1 Is located primarily In the cytoplasm of the Iver. Arginase consists of three tetramers, and the enzyme requires a two-molecule metal duster of manganese In order to malntain proper function. These Mn2+ kons coordinate with water,...

THC of bol2- on an FFPE Follicular Lymphoma Tivsue bel-2 Is an Integral cuter mitochondrial membrane protein that blocks the apoptotic death of some cells such az lymphocytes Constitutive expression of bol-2, such as In the case of wanslocation of becl-2 |g heavy-chain to be the cause to lod, ks tought of Folllcular Lymphoma. Antl-bl-2 has shown consistent negathe reaction on reacthee germinal centers and positive staining of neoplastic follicles In Follicular Lyrmiphorna. Consequenthy, this antibody [svaluable when distinguishing between reacties and neoplastic In hmnph follicular...