BIO X brochure
16Pages

WE CREATE THE FUTURE OF HEALTH

What is Bioink? A bioink is a biomaterial that is suitable for bioprinting with cells and provides a temporary or permanent support to the cells while they produce their own extracellular matrix. Bioinks based on biopolymers, such as collagen, gelatin, hyaluronan, silk, alginate and nanocellulose, are known for their favorable biocompatible properties and are attractive biomaterials for cell encapsulation and 3D bioprinting. These bioinks provide an aqueous 3D environment with biologically relevant chemical and physical signals, mimicking the natural extracellular matrix environment....

We are CELLINK We are a team of entrepreneurs, scientists, engineers and pioneers, pushing the limits for what’s possible, paving the way for the future of regenerative medicine. With our 3D bioprinters and bioinks, we will open the possibility for more extensive medical research. Together with our collaborators,in hundreds of labs in more than 50 countries, we work side by side to ensure quality and support. Our compassion for humans and drive to create an impact will pave the way for continued growth.

“There was a clear difference in CELLINK’s customer approach, product robustness and confidence in their products, all of which made CELLINK stand alone in the market of 3D bioprinting. We trusted the company and now looking back we think it was not a wrong decision to go with CELLINK.” - Dr. Nath, Harvard Medical School “Thanks CELLINK for engaging the students and holding this successful workshop on bioprinting” - Ric Levato, UMC Utrecht “CELLINK has taken our feedback and adapted their system while being actively engaged in the process” - Dr. Grande, The Feinstein Institute for Medic

Meet the BIO X BIO X is the most user-friendly and flexible bioprinter in the world, providing the user with an unparalleled bioprinting experience. The built-in features along with the new BIO X software managed through the large touchscreen display minimize the learning curve and ensure you will receive the results you want. Bioprinted tissue can be used in drug discovery where researchers can test new potential treatments and evaluate efficacy in very early stages. New drugs and treatments will potentially reach clinical trials faster with a decreased number of failures and reduced need...

Wider print pressure range Temperature control Multihead builds More printheads Better print resolution printheads/ toolheads 2 mounts 1 printhead Before Room temp printbed

Designed with scientists in mind YOU SPOKE, WE LISTENED! When developing the BIO X, we at CELLINK reached out to you, our fellow scientists and users, to get your feedback on our INKREDIBLE and INKREDIBLE+ bioprinters, and to better understand your needs in 3D bioprinting. We asked what current features you would want to improve, and what non-existing features you’d like to see in the next-generation bioprinter. You can find the most common answers in the diagram below. Temperature control Easier to adjust precisely Wider print pressure range Better display Multihead builds Better print...

INDEPENDENT AND COMPACT LAB FOOTPRINT Both a compressor and cooling unit have been integrated into the BIO X, without compromising its size. When printing cells, a sterile environment is key. Working in a laminar flow cabinet is sometimes needed, but but impossible to do if your equipment can’t fit. BIO X has a small footprint but still contains every component you need to bioprint. It’s a complete standalone unit, facilitating work in a laminar flow cabinet without the need for external connections. Even though the BIO X works perfectly on its own, you might sometimes want to increase...

SYRINGE PUMP CURING TOOL TOOL HEAD Intelligent & exchangeable To make sure that all the necessities for your research are easily available, we supply several of the handiest printheads and tool heads you may need when using BIO X. BIO X is a versatile bioprinter equipped with intelligent printhead mounts. This means you’ll have the opportunity to easily upgrade your system as we develop new printheads to match your evolving bioprinting needs. The printheads we provide are carefully selected and of the highest quality. We strive to meet your standards and we compromise nothing in the process...

Compatible materials The BIO X is capable of fabricating constructs containing any type of cell, enabling the production of any tissue target found in the body. These constructs can be utilized in a wide range of applications through the incorporation of bone marrow stromal cells or mesenchymal stem cells. The system can use specialized cells like chondrocytes or fibroblasts for cartilage and dermal applications respectively. Build vascular networks within your constructs using. BIO X can bioprint hepatocytes to rapidly create 3D models for drug screening. You can add stellate cells to...

Clean. Reinvented BIO X is equipped with dual high-power fans that create a powerful airflow through its dual-filtration top, creating a positive air pressure inside the chamber. The air first travels downwards through a prefilter, which retains the bigger particles, and then through a HEPA H14 filter, which sorts out even the smallest of particles. The dual- power fans fill the chamber with filtered air at a positive pressure to keep your experiment clear. The BIO X is made without sharp corners. Its design only uses rounded shapes to ensure that no unwanted particles get trapped inside...

Easy printing process 321 CELL MIXING We have developed the easiest and most homogenous way of doing this using our innovative CELLMIXER. Put the bioink in the 3 mL syringe and your cells in suspension media in the 1 mL syringe. Clip each syringe to the dispensing unit, connect the mixing unit to the tip of each syringe and then connect the filling-cartridge. Fill the cartridge by gently injecting the ink and cells through the mixing unit. Your filling-cartridge is now ready for bioprinting and can be disconnected from the mixing unit. BIOPRINTING When the cell mixing is done and your...