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Xpert® C. difficile BT

Xpert®  C. difficile BT

Xpert® C. difficile BT

Product catalog summary
Introduction
Xpert® C. difficile BT is an in vitro diagnostic medical device designed for the rapid detection of Clostridium difficile infections (CDI) in 47 minutes. This test is crucial for early detection and isolation of infected patients to prevent transmission in healthcare settings.

The Need
CDI incidence and severity have been increasing, leading to longer hospital stays, higher costs, and increased morbidity and mortality. Highly virulent strains, such as 027-NAP1-BI, have caused severe outbreaks with high mortality rates. The presence of binary toxin (BT) is linked to disease severity and outcomes.

The Solution
Xpert® C. difficile BT detects toxin-producing C. difficile by targeting toxin B (tcdB), binary toxin (cdtA), and a tcdC deletion at nucleotide 117. This allows for the presumptive identification of the 027/NAP/BI strain and independent binary toxin results, eliminating the need for additional testing.

Impact and Benefits
The test enables clinicians to initiate therapy and infection control measures sooner, improving patient management. It reduces the spread of infection and associated costs, which can reach up to €15,000 per infection.

Performance
In a prospective investigation, Xpert® C. difficile BT demonstrated a sensitivity of 93.4% and specificity of 94.0% when compared to broth-enriched toxigenic culture.

Workflow
The test involves three simple steps: inserting a swab into the stool specimen, vortexing and dispensing the sample, and starting the test. The total hands-on time is less than one minute.

Contact Information
Corporate Headquarters: 904 Caribbean Drive, Sunnyvale, CA 94089 USA. Phone: +1.408.541.4191. European Headquarters: Vira Solelh, 81470 Maurens-Scopont France. Phone: +33.563.82.53.00.

References
References include studies and articles from journals such as Emerging Infectious Diseases and the Journal of Clinical Microbiology.
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Catalog excerpts

Xpert®  C. difficile BT-1

Rapid and Accurate. It’s About Time. Xpert® C. difficile BT Detection of Clostridium difficile in 47 minutes. C€ m In Vitro Diagnostic Medical Device A better way.

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Xpert®  C. difficile BT-2

Patients infected with C. difficile are a source of transmission to other patients, therefore, it is important that infected patients are detected as early as possible. Rapid molecular testing, providing accurate results in 47 minutes, when combined with isolation of infected patients, provides an important new weapon in our battle against healthcare-associated infections.” Professor Richard James Director of the Center for Healthcare Associated Infections, University of Nottingham C. difficile infections (CDI) have been increasing in incidence and severity, and are associated with an increase...

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Xpert®  C. difficile BT-3

© THE IMPACT With Xpert® C. difficile BT: • Clinicians can promptly administer therapy to support improved patient outcomes • Timely infection control initiatives can be implemented to reduce spread of infection within an institution8 • Speed and accuracy eliminates the need for additional testing • Identify the presence of the gene encoding binary toxin, which has been linked with increased disease severity and poorer patients outcomes • Detect strains of C. difficile that only produce binary toxin, which may still be associated with CDI Performance characteristics of Xpert® C. difficile were...

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Xpert®  C. difficile BT-4

3 EASY STEPS Total hands-on time: <1 Minute Insert swab into stool specimen, then into elution reagent vial and break at score Vortex and dispense sample into port S 3 Insert cartridge and start test Xpert® C. difficile BT is a rapid PCR test that detects the presence of toxin-producing Clostridium difficile in 47 minutes. Detection of three targets: toxin B (tcdB), binary toxin (cdtA), and a tcdC deletion at nucleotide 117, offers presumptive identification of the 027/NAP/BI epidemic strain and an independent call-out of binary toxin results. CATALOG NUMBER Xpert C. difficile BT (10 tests) ....

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*Prices are pre-tax. They exclude delivery charges and customs duties and do not include additional charges for installation or activation options. Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates.