Celsis Advance II™ System for Rapid Microbial Testing Benefits of the Celsis® System As the world’s leading innovator in rapid methods, Charles River’s Celsis Advance II™ systems are used globally by • Shortened production cycles results in as little as 18-24 hours, enabling rapid confirmation of product quality and quick release to market. This in turn • Reduced inventory requirements eliminates days from inventory requirements and production cycle times, reduces warehousing costs and working-capital • Decreased working capital requirements leading manufacturers in the home, beauty, and pharmaceutical industries. The Celsis® platform delivers quality assurance requirements and improves overall profitability. Quantifiable Savings • Faster release of product to market With our Financial Impact Assessment (FIA), Charles River can evaluate the cost savings of implementing a Celsis® system • Lower safety stock needs finished goods, testing volume, and the number of days products are held in quarantine – the FIA projects the 5-year Net • Faster response to contamination events Present Value (NPV) of a company’s investment in a Celsis® system. The 5-year NPV for an average manufacturing facility • Higher sample throughput than Celsis Accel® in a particular manufacturing facility. Using readily available, company-specific information – including the daily value of is in excess of $500,000, and most plants realize a return on investment in just 6-9 months. Advance II™ System The Celsis Advance II™ allows for complete and automated control over testing protocols, data analysis and archiving. Security features provide data integrity as well as system and records security in accordance with the FDA’s 21 CFR Part 11 and the European Union’s Annex 11.

Features Remote Access: A secure Remote User option allows monitoring of product quality testing results from multiple locations and includes full access to the Report Generator for running queries, analyses, and reports from a local or remote network location. Data Analysis: Celsis Advance II™ provides a powerful suite of tools to manage data archiving, results analysis, and reporting, including remote user capability. Local and remote users can quickly query results, design and generate graphs for easy data trending analysis, customize and print reports, and more. Celsis Advance® Luminometer...

Celsis Rapid Microbial Detection ® Product Line Celsis Advance II™ system Celsis Advance II™ Celsis® Advance II.im software USB-serial cable Power supply Cuvette rack Reagent rack On-site basic preventive maintenance only On-site standard On-site premier Celsis Advance II™ Service and Support Daily wash & rinse kit Monthly maintenance and cleaning kit AMPiScreen® Reagents LumiScreen™ Reagents Support Reagents and Consumables [email protected] • www.criver.com © 2018, Charles River Laboratories I