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BioPharma Processing

Product catalog summary

Overview: The document provides a comprehensive overview of Cole-Parmer's offerings in fluid handling solutions, particularly for the biopharmaceutical and pharmaceutical industries. It highlights the company's extensive product range, including pumps, tubing, filtration systems, and process monitoring equipment, designed to meet various laboratory and production needs.

Key Sections:

Product Range: Cole-Parmer offers over 100,000 products, including Masterflex® pump systems, Ismatec® pumps, and various tubing and filtration solutions. These products are designed to optimize research, scale-up, and full production systems.
Industry Compliance: The company boasts a 100% compliance rate with customer quality audits and a 99.7% accuracy in recommending products that meet customer needs. They provide certificates of material compliance and other documentation to ensure adherence to industry standards.
Applications: The document outlines various applications for their products, such as media preparation, fermentation, harvesting, purification, and fluid transfer. Each application is supported by specific product recommendations to ensure optimal performance.
Technical Specifications: Detailed specifications for various pump models are provided, including flow rates, motor types, and control features. The document emphasizes the precision and reliability of their pump systems, suitable for both small-scale laboratory use and large-scale production.
Customer Support: Cole-Parmer offers expert product assistance and troubleshooting support, ensuring customers can find the right products for their specific applications.

Conclusion: Cole-Parmer positions itself as a leader in fluid handling solutions, with a strong focus on customer satisfaction, product accuracy, and compliance with industry standards. Their extensive product range and technical support services are designed to meet the diverse needs of the biopharmaceutical and pharmaceutical sectors.

Overview: The document provides detailed information on various types of pump tubing and related accessories offered by Cole-Parmer, specifically designed for use in biotechnology and pharmaceutical industries. The tubing is compatible with Masterflex pumps and meets USP Class VI requirements.

Specifications:

PharmaPure®: Biocompatibility similar to PharMed BPT, long life under continuous pressure, available in 7.6 m (25 ft) packs.
Chem-Durance® Bio: Excellent chemical resistance, plasticizer-free inner liner, available in 15.2 m (50 ft) packs.
Solve-Flex®: Excellent chemical resistance to solvents, low spallation fluoropolymer-lined tubing, available in 3.6 m (12 ft) packs.
Tygon® E-LFL: Longest life of all Tygon formulations, meets USP Class VI, EU Pharmacopoeia 3.2.9, FDA 21, available in 7.6 m (25 ft) packs.
Tygon E-Lab (E3603): Ideal for general transfer applications, clear for easy monitoring, available in 15.2 m (50 ft) packs.
GORE® STA-PURE® Series PCS and PFL: Long life under pressures up to 60 psi, excellent flow stability and biocompatibility, available in 35.6 cm (14") packs.

Procedures and Recommendations:

Masterflex pump tubing is custom extruded to fit Masterflex pumps, ensuring performance with pressure, suction lift, and viscous fluid applications.
All formulations meet USP Class VI requirements, with some also being RoHS and ADCF compliant.
Free certificate of compliance is available upon request.

Product Options:

Masterflex L/S Spooled Pump Tubing: Offers bulk purchase options to reduce scrap and ensure availability.
Masterflex L/S Bulk-Packed Pump Tubing: Prevents contamination with individually bagged coils, ideal for large-volume users.

Accessories:

Push/pull clamps and various adapters are available for quick and secure connections.
Sanitary tubing options include platinum-cured silicone and PharMed BPT, conforming to USP Class VI and FDA standards.

Applications:

Media transfer, filling/emptying large carboys and bags, pumping fermentation chemicals, purification/filtration, and production filtration.

Contact Information: For more details or to place an order, contact Cole-Parmer via phone, fax, or email, or visit their website.

Overview: The document provides detailed information on Masterflex® I/P® Variable-Speed Modular Digital Dispensing Pumps and associated tubing products offered by Cole-Parmer. It includes specifications, features, applications, and ordering information for various pump models and tubing types.

Specifications: The pumps offer a wide range of flow rates from 0.00001 to 3400 mL/min, with specific models supporting up to 42 LPM. The pumps are designed for flexibility in volume and time of dispense, featuring programmable dispense intervals and multiple operating modes.

Features: Key features include a brushless motor for quiet, maintenance-free operation, remote control capabilities, and the ability to accept up to two pump heads. The pumps are available with either benchtop or wall-mount controllers, with varying degrees of splash and washdown resistance.

Applications: The pumps are suitable for biotech and pharmaceutical processing applications, including nutrient addition, buffer injection, and fermentation transfer. The gentle pumping action is ideal for shear-sensitive fluids containing proteins and other large molecules.

Tubing Information: The document details various tubing formulations, including silicone, PharMed® BPT, and C-Flex®, each engineered for specific applications. Tubing is available in continuous lengths to minimize contamination and is compliant with USP Class VI requirements.

Ordering and Accessories: The document provides catalog numbers and pricing for different pump and tubing configurations. It also includes information on accessories such as extension cables, clamps, and gaskets necessary for system integration.

Recommendations: For applications requiring high pressure or involving viscous fluids, High-Performance Precision tubing is recommended. Users are advised to consider flow rate, pressure, temperature, and other factors when selecting tubing.

Contact Information: For further assistance, customers are encouraged to contact Cole-Parmer via phone, fax, or email, with contact details provided.

Specifications and Features:
1. Compressor Requirements: Minimum air requirement is 24 cfm (0.68 m3) at 100 psi (6.9 bar).
2. Motor Protection: IP56-rated motor protects against dust and strong water jets.
3. ATEX and NEC Ratings: Rated for ATEX Zone 2 EEx II 3 G c IIC T6 and NEC Class 1, Division 2, Groups A, B, C, D, T6.

Variable-Speed Modular Pump:
- Washdown controller can be placed conveniently with a 4.9-m cord.
- Reversible motor allows purging before or after pumping.

Variable-Speed Modular Digital Pump:
- Offers high-volume, high-accuracy dispensing.
- Can dispense by volume or time, or pump continuously.
- Motor and controller can be separated by up to 1.8 m.

Included Components:
- Rapid-Load® pump head, 1 m of Tygon® E-LFL B/T 91 pump tubing, and a 1.8-m power cord.

Applications:
- Suitable for transferring shear-sensitive and viscous fluids, media transfer, production fermentation, and media bag fill.

Motor Specifications:
- Fixed-speed and variable-speed options with different motor sizes and IP ratings.
- Dimensions and power requirements vary by model.

Masterflex® B/T® Pump Tubing:
- Optimized for use in B/T pumps with retention marks for exact placement.
- Various tubing formulations available, all meeting USP Class VI requirements.

Liqui-Sense® Emergency Cut-Off System:
- Monitors pumps and fluid systems for leaks, fluid level, and flow 24/7.
- Shuts down processes automatically to prevent downtime and fluid loss.

Ismatec® Pumps:
- Independent Channel Control (ICC) Pumps allow different speeds and directions for each channel.
- Flow range of 0.0001 to 43 mL/min, with USB interface for computer connections.
- Available in multiple channel configurations for application flexibility.

Accessories:
- Various tubing retainers and retainer tools for secure connections.
- Optional minicartridge with adjustable occlusion for manual pressure variation.

Pressure Specifications:
- Click’n’go cassettes can handle up to 14.5 psi (1 bar).
- Pressure lever cassettes can handle up to 22 psi (1.5 bar).

Pump Specifications:
- Reglo Digital pump 78017-02 is fully programmable.
- Flow range per channel varies with the number of channels and rollers, with speeds ranging from 2.0 to 160 rpm.
- Available in both analogue and digital models with different flow ranges and channel configurations.

Features of Ismatec® Reglo Compact Multichannel Pumps:
- Consistent flow and reduced tubing wear.
- Small footprint for standalone use.
- Balanced pulsation control with various channel and roller configurations.
- Self-lubricating rollers and easy channel changes with Click’n’go™ minicartridges.
- Uniform channel-to-channel performance with spring-tensioning design.

Control Features:
- Analogue pumps have adjustable speed in 1% steps and can be controlled remotely.
- Digital programmable pumps offer four modes of operation and feature analogue input/output controls and RS-232 interface for computer control.

Tubing Options:
- Various tubing materials available, including Tygon®, Silicone, Viton®, and PharMed® BPT, each with specific compliance and resistance properties.
- Tubing is available in 2-stop and 3-stop configurations, with color-coded stops for easy identification.

Accessories:
- Optional adjustable occlusion cassette, replacement Click’n’go™ cassette, foot switch, and NIST-traceable calibration available.

Ismatec® Ecoline Pumps:
- Space-saving design with stackable pumps.
- Durable stainless steel housing and simple operation.
- Remote control capability via analogue input signals.

Ismatec® Flowmaster™ Pump:
- Stainless steel construction suitable for sanitary fluid transfer.
- Easy cleaning and quick tubing changes.
- Meets biotech, food, and pharmaceutical industry standards.

Overview: The document provides detailed specifications and features of various pump systems offered by Cole-Parmer, including peristaltic pumps, syringe pumps, and gear pump heads. It highlights their applications, technical specifications, and unique features.

Peristaltic Pumps: These pumps feature remote speed control, multiple overload protection, and an extensive analog interface for process control systems. They are suitable for applications such as bulk container pumping, FDA tablet coating, fermentation addition, cell culture, and filtration. The pumps offer a flow range of 0.001 to 3700 mL/min and are equipped with IP65-rated washdown drives.

Syringe Pumps: Cole-Parmer offers a range of syringe pumps designed for low-flow, low-pressure applications. These pumps provide accurate and precise fluid delivery with features like nonvolatile memory, RS-232 connectivity, and programmable operations. They are suitable for drug infusion, nutritional infusion, microdialysis, and perfusion applications.

Touch-Screen Syringe Pumps: These pumps offer intuitive programming and control with a touch-screen display. They support flow rates from 5 pL/min to 220 mL/min and can daisy chain up to 99 pumps. They are ideal for drug discovery, electrospinning, nanofluidics, and flow cytometry applications.

Gear Pump Heads: The Micropump A-Mount Gear Pump Heads provide leak-free, pulseless flow with magnetic drive and static seals. They are designed for higher inlet pressures and offer flexibility with modular design. These pump heads are suitable for handling a wide range of materials due to their chemical-resistant materials.

Specifications and Features: The document includes detailed specifications for each pump type, including flow rates, pressure ratings, materials, and connectivity options. It also provides catalog numbers and pricing information for easy reference.

Specifications:
The document provides detailed specifications for various fluid transfer pumps, including suction lift capabilities, duty cycles, and motor specifications. The pumps are designed for continuous operation and feature digital gear drives with remote control options for easier setup and operation. The pumps can be controlled remotely via DB25 connectors and offer pulse-free flow when combined with specific pump heads.

Procedures:
The document outlines the setup and operation procedures for the Cole-Parmer Digital Gear Drive, including the use of a foot switch for start/stop operations and the graphical LCD that displays four operating modes. It also describes the use of single-use pump heads for steady, pulseless flow, ideal for dosing applications.

Norms and Standards:
The high-pressure piston pumps meet specific sanitary standards for use with foods, ensuring compliance with industry norms. The pumps are designed to integrate easily into laboratory or industrial environments, with features like self-flush and pressure sensors to alert users to malfunctions.

Recommendations:
The document recommends using the pumps for a variety of applications, including precise chemical metering, dispensing, and chromatography. It highlights the benefits of using single-use pump heads to eliminate cross-contamination and reduce cleaning requirements.

Key Data from Tables and Graphs:
The document includes performance data for the pumps, such as flow rates, accuracy, and pressure ranges. It also provides information on the materials of construction for the pump heads and wetted materials, ensuring compatibility with various fluids.

Critical Information:
The pumps offer high precision and repeatability, with features like antidrip functions and preprogrammed calibration for accurate dispensing. The document emphasizes the importance of selecting the right pump for specific applications and provides contact information for expert assistance.

Sanitary Centrifugal Pumps
These pumps are designed to eliminate piping changes with an interchangeable design. They offer flow rates up to 450 LPM and are constructed with 316L stainless steel. Washdown motors are available in white epoxy or stainless steel. Heavy-duty versions have thicker casings and are suitable for Steam-in-Place (SIP) applications. They feature Tri-Clamp® connections and are available in single- or three-phase options, providing gentle product handling up to 1200 cp.

Custom Pump Systems
Cole-Parmer offers custom-designed and preassembled pump systems to meet specific requirements. These systems are prebuilt and pretested, eliminating the need for on-site assembly of individual components. The "Plug and Play" skids require only connection of inlets, outlets, and power.

Sanitary Washdown Rotary Lobe Pumps
These low-maintenance pumps conform to 3A Sanitary Standards and offer flow rates up to 570 LPM with viscosities up to 10,000 cp. They feature noncontacting rotors to reduce particle shedding and are approved to EHEDG and CIP/SIP standards. The pumps include NEMA 4 washdown motors and variable-speed controllers.

Electric and Air Motors
Electric motors are splashproof and corrosion-resistant, with built-in overload protection. Heavy-duty motors are suitable for high output applications. Air-operated motors are ideal for hazardous-duty applications and feature a muffler and grounding post.

Tube Sets
Standard tube sets are seal-less for low maintenance, available in polypropylene, PVDF, and stainless steel. Sanitary centrifugal tube sets are easy to disassemble and clean, suitable for low-viscosity liquids.

Drum and Container Pumps
These pumps are designed for safe liquid transfer from drums and tanks, available with electric or air motors for ATEX Zone 1. They feature no mechanical seals and can run dry. Accessory kits are available for specific applications.

High-Capacity Vacuum/Pressure Pumps
These pumps feature a shaded-pole fan-cooled motor with a thermal overload switch. They offer free-air capacities up to 51 L/min and are available with or without gauges, regulators, and valves.

Diaphragm Vacuum Pumps
These pumps minimize noise and are available in general-purpose and chemical-resistant models. They are ideal for vacuum/pressure filtration, cryogenics, and distillation, providing a nearly maintenance-free service life.

Vacuum Pump Specifications and Features
The document describes various vacuum pumps and their features. The 79103-series pump is recommended for general-purpose applications, while the 79104-series pump is suitable for highly corrosive environments due to its chemical-resistant wetted parts. Pumps with a gas ballast valve are ideal for handling condensable gases.

Self-Adjusting Vacuum System
This system allows for automatic regulation of vacuum conditions, reducing evaporation time by up to 30% and minimizing bumping and foaming. It features a built-in solvent recovery system and controller, requires low maintenance, and operates quietly.

Diaphragm Vacuum Pump
The pump features a corrosion-resistant flow path and integrated gas ballast, achieving vacuum pressures down to 2 mbar (1.5 Torr). It includes a digital vacuum controller with a graphic interface, allowing for quick manual adjustments and the ability to save up to ten user-defined multistep programs. An RS-232 port enables computerized control.

Included Components
The package includes an oil-free pump, a digital vacuum controller with an integral solvent recovery system, and a power cord.

Technical Specifications
The pump has three stages, a free-air capacity of 33 L/min, and a maximum vacuum with gas ballast of 4 mbar (3 Torr). The wetted parts are made of PTFE, ETFE (carbon fiber reinforced), and FFKM. It operates at a noise level of 42 dB and requires a 230 VAC, 50/60 Hz power supply.

Fluid Path Tubing
The document also details various types of silicone tubing, including peroxide-cured and platinum-cured options. These tubings are characterized by excellent heat resistance, low compression set, and compliance with FDA and USP Class VI standards. They are suitable for sterilization by autoclave or gamma irradiation.

Product Support
For assistance with product selection or troubleshooting, contact the expert Application Specialists at the provided contact details.

Specifications:
Tygon® 3350 silicone tubing is platinum cured with an ultra-smooth inner surface to reduce particle entrapment and bacterial growth. It is suitable for mild to medium concentration bases, salts, and alcohols, and is odorless, tasteless, and nontoxic. The tubing is transparent and FDA-compliant, meeting USP Class VI and EP 3.2.9 requirements. It can withstand temperatures from –80 to 200°C and can be sterilized using ethylene oxide, gamma irradiation, or autoclave.

Procedures:
For sterilization, use ethylene oxide, gamma irradiation, or autoclave for 30 minutes at 1.0 bar.

Norms and Certifications:
The tubing complies with FDA (21 CFR 177.2600), USP Class VI, and EP 3.2.9 standards. It is manufactured according to GMP.

Recommendations:
Use Tygon® BioPharm Silicone Tubing to reduce particle entrapment and ensure compliance with industry standards. For applications requiring high chemical resistance and low gas permeability, C-Flex® Tubing is recommended, available in standard, clear, and ADCF formulations.

Key Data from Tables:
The document provides detailed dimensions and pressure ratings for various tubing types, including C-Flex, Cole-Parmer Flexible PVC, and PTFE Tubing. Each type has specific characteristics, certifications, and temperature ranges suitable for different applications, such as chemical resistance, biocompatibility, and high-temperature work.

Critical Information:
Ensure the correct tubing type is selected based on application requirements, such as chemical resistance, temperature range, and compliance with regulatory standards. Certificates of compliance are available upon request, listing relevant regulatory and agency compliance.

Specifications:
1. PVDF (Polyvinylidene Fluoride): Offers excellent chemical resistance with a temperature range of –62 to 129°C. It can be sterilized using ethylene oxide or autoclave.
2. Polypropylene (PP): Provides very good chemical resistance with a temperature range of –13 to 66°C. Sterilization can be done via ethylene oxide or gamma irradiation.

Product Offerings:
The document lists various types of connectors and fittings, including reducing connectors, elbow connectors, T connectors, Y connectors, and press-in plugs. These are available in different sizes and materials (PP and PVDF), with specific catalog numbers and quantities per pack.

Key Features:
- Barbed fittings are designed for quick and easy assembly without tools, suitable for low-pressure applications (less than 2.1 bar or 30 psi).
- Single barb fittings are recommended over multi-barb fittings for better sealing as they allow the tubing to relax around the barb.

Compliance and Certification:
Cole-Parmer provides a free certificate of compliance with each order of fittings or tubing. This certificate includes details such as the company’s PO number, order reference number, catalog number, formulation, compound number, lot number, and compliance with regulations and agencies like FDA, USP, USDA, National Formulary, NSF International, GMP, and 3A.

Additional Information:
- The document also mentions CPC™ Plastic Quick-Disconnect Fittings and CPC™ High-Flow Quick-Disconnect Couplings, highlighting their features such as automatic shutoff valves and compliance with USP Class VI requirements.
- AseptiQuik™ Connectors are noted for their easy, secure sterile connections with a quick, three-step process to reduce operator error.

Overview: This document provides detailed specifications and product information for various sanitary fittings and connectors used in fluid path systems, particularly in pharmaceutical and food processing industries. It includes details on materials, temperature and pressure ratings, sterilization methods, and compatibility with industry standards.

Specifications:

Materials: Polysulfone body, silicone O-rings, 316 stainless steel valve springs.
Temperature Range: –40 to 138°C.
Pressure Range: Vacuum to 125 psi (8.62 bar).
Sterilization Methods: Autoclave or gamma irradiation.

Product Categories:

Hose Barb Bodies and Inserts: Available in various sizes with catalog numbers for ordering.
Steam-in-Place Connectors: Designed for sterile connections, reducing downtime and cleaning expenses. Available in single and two-cycle steam processes.
Quick-Disconnect Sanitary Couplings: Allow integration with existing systems, featuring USP Class VI materials and multiple sterilization options.
Clamp Fittings: Made from polypropylene (PP) and PVDF, offering excellent chemical resistance and compatibility with Tri-Clamp fittings.
Stainless Steel Sanitary Clamp Couplings: Meet FDA and 3A Sanitary Standards, ideal for pharmaceutical applications.

Key Features:

All products meet USP Class VI standards and are free of animal-derived ingredients.
Various fittings and adapters are available to match different sanitary and bioreactor systems.
Products are designed to ensure a tight seal and maintain sanitary conditions.

Recommendations:

Choose PVDF materials for applications requiring high-temperature tolerance and consistent performance after repeated autoclaving.
Use platinum-cured silicone gaskets for most pharmaceutical and food processing applications due to their odorless and tasteless properties.

Cole-Parmer Premium Luer Fittings
These fittings are manufactured from 100% virgin raw materials to ISO Class 8 standards, ensuring process integrity with full material traceability. They are ideal for critical applications such as syringes or small tubing and comply with ISO 594-1 standards. The fittings are inspected to be free from contaminants and are fully traceable, meeting tight dimensional tolerances for increased reliability and process purity. Available in sizes ranging from 1/16" to 1/4" with various connection options, they are sold in packs of 25.

Materials and Specifications
- Polypropylene (PP): Animal-free, meets USP Class VI specifications, max temperature 87°C, sterilizable by ethylene oxide and gamma irradiation.
- Polycarbonate (PC): Good chemical resistance, max temperature 133°C, sterilizable by ethylene oxide and gamma irradiation.
- Nylon: Good chemical resistance, max temperature 235°C, sterilizable by autoclave, ethylene oxide, or gamma irradiation.
- PVDF: Excellent chemical resistance, animal-derived ingredient-free, max temperature 117°C, sterilizable by autoclave, ethylene oxide, or gamma irradiation.

Chromatography Fittings
High-quality stainless steel and PEEK fittings are available for chromatography applications. These include nuts, ferrules, tees, crosses, and unions, designed to connect tubing with zero dead volume. The fittings are suitable for high-pressure applications, with some models capable of withstanding up to 689 bar/10,000 psi.

Solenoid Valves
Cole-Parmer offers two- and three-way direct lift solenoid valves made of inert PTFE, ideal for high-purity or corrosive fluids. These valves minimize trapped liquids with minimal dead volume and are lightweight and compact, allowing for versatile mounting options. Models are available with different orifice sizes and pressure ratings.

Overview: The document provides detailed specifications and product information for various types of valves, tanks, and filtration systems offered by Cole-Parmer. It includes technical specifications, applications, and pricing for solenoid-operated pinch valves, sanitary ball and butterfly valves, high-purity plastic diaphragm valves, and more.

1. Solenoid-Operated Pinch Valves:

Designed for sanitary and pharmaceutical applications with no contamination of the valve.
Available in two-way and three-way configurations, with fast response time and low power consumption.
Specifications include maximum fluid temperature of 70°C and lead wire length of 38 cm.
Includes PTFE-coated lead wires and silicone tubing for two-way valves, and additional tubing for three-way valves.

2. Sanitary Ball and Butterfly Valves:

Made from 316 stainless steel, compatible with Tri-Clamp fittings, and meet USDA requirements.
Ball valves have a maximum pressure of 68.9 bar at 21°C and a maximum temperature of 204°C.
Butterfly valves have a maximum pressure of 9.9 bar at 20°C and a maximum temperature of 93°C.

3. High-Purity Plastic Diaphragm Valves:

Eliminate leaks and are fully drainable, with models offering additional chemical resistance.
Available in polypropylene and PVDF body materials, with working pressures ranging from 4.1 to 8.6 bar.
Temperature range for polypropylene is -20 to 79°C, and for PVDF is -20 to 99°C.

4. Cylindrical Tanks:

Made from HDPE and PP, compliant with FDA 21 CFR 177.1520.
Designed for near-total drainage and rated for use with 1.8 specific gravity media.
HDPE tanks have a maximum temperature of 65°C, while PP tanks can withstand up to 104°C.

5. Filtration Systems:

Includes Advantec glass and quartz fiber filters, ideal for analytical or gravimetric studies.
Filters are resistant to chemicals and pH extremes, with some capable of withstanding temperatures up to 1000°C.
Qualitative filter papers are available for solutions with pH up to 12, with low ash content.

Conclusion: The document provides comprehensive information on a range of fluid handling and filtration products, highlighting their specifications, applications, and compatibility with various industrial standards.

Overview: The document provides detailed specifications and applications for various types of filter papers and membranes used in filtration and purification processes. It includes information on Advantec® Quantitative Filter Papers, Advantec® Mixed Cellulose Filter Membranes, Millipore® Ultrafiltration Disc Membranes, and Cole-Parmer® Syringe Filters, among others.

Filter Papers: The document lists different grades of Advantec® Quantitative Filter Papers, highlighting their ashless nature, retention capabilities, flow rates, and specific applications. For example, No. 4A is suitable for high-pressure environments and retains fine crystalline precipitates, while No. 5A is designed for fast flow rates and retaining coarse particulates.

Specifications: Each filter paper grade is detailed with nominal ratings, thickness, weight, flow time, absorption speed, and wet strength. These specifications help in selecting the appropriate filter paper based on the filtration needs.

Filter Membranes: Advantec® Mixed Cellulose Filter Membranes are presterilized and available in various pore sizes and packaging options. They are ideal for microbiological analysis and are offered with or without grid lines for easy colony counting.

Ultrafiltration Membranes: Millipore® Ultrafiltration Disc Membranes are made of regenerated cellulose and are suitable for concentrating or desalting dilute solutions. They are available in different nominal molecular weight limits (NMWL) and sizes.

Syringe Filters: Cole-Parmer® Syringe Filters are designed for easy and reliable filtration. They are available in sterile and nonsterile options, with various membrane types like PTFE, nitrocellulose, and cellulose acetate, each suited for specific applications such as aggressive chemical filtration or microbiological analysis.

Pressure Filtration Holders: Advantec® Pressure Filtration Holders are made of stainless steel and are designed to maximize flow rates by applying positive pressure. They are autoclavable and feature sanitary connections for easy cleaning.

Hollow Fiber Filter Capsules: Minntech® Hollow Fiber Filter Capsules offer high flow rates with low pressure drop and are suitable for steam sterilization. They provide a large surface area for greater capacity and longer filter life.

Contact Information: For further assistance and product selection, contact details for Cole-Parmer are provided, including phone numbers and email addresses.

Specifications and Features:
1. Advantec Disposable Capsule Filters: These filters are ideal for removing contaminants such as bacteria, endotoxins, spores, and pyrogens. They are sterilizable by autoclave or ethylene oxide, with a maximum operating pressure of 3.9 bar and temperature of 60°C. The filters are available in various pore sizes and are designed for high dirt-holding capacity and superior retention.

2. Sterilized Sampling Bottle Assemblies: These assemblies are designed for safe transfer, sampling, and storage of biopharmaceutical products. They feature a secure, single-piece cap/tubing assembly to eliminate contamination and product loss. The assemblies are pre-sterilized by gamma irradiation and include a seamless liner with premolded C-Flex fill and vent tubes.

3. Thermo Scientific Nalgene Reusable Bottletop Filter Holders: These holders maximize throughput and are usable with glass media bottles. They are autoclavable and noncytotoxic, featuring a vacuum port and molded-in graduations.

4. Advantec All-Glass Filtration Assemblies: These assemblies preserve sample purity and are ideal for high-purity and aggressive chemical applications. They include a funnel, support base, receiving flask, and clamp.

5. CultureGard Hollow Fiber Filter: This filter reduces contamination risk with a naturally hydrophilic cellulose hollow fiber membrane. It is made of polysulfone housing and end caps, featuring a polypropylene autovent.

6. Sanitary Strainers: Designed to protect products and equipment from particulates, these strainers feature 316 stainless steel wetted surfaces and are available in various mesh sizes.

7. Parker Process Liquid Filter Systems: These systems are designed for sanitary liquid applications with high-quality construction and are suitable for use with various filter cartridges.

Applications and Recommendations:
- The products are suitable for a range of applications including perfusion, bioreactor feed, and sterile liquid filtration.
- The document emphasizes the importance of selecting the right product for specific applications and offers expert assistance for product selection and troubleshooting.

Key Parameters and Limitations:
- Maximum differential pressure for certain filters is specified as 30 psi (2 bar).
- Temperature and pressure limits are provided for various products, ensuring safe and effective use.

Best Practices:
- Use pre-sterilized products to eliminate labor and validation costs associated with assembly and cleaning.
- Ensure proper installation and maintenance of filtration systems to maximize efficiency and product purity.

Overview: The document provides detailed specifications and options for various flow measurement and mixing equipment, primarily focusing on turbine flowmeters, displays, mass flowmeters, and mixers. It includes technical specifications, catalog numbers, and pricing information.

1. Flanged Turbine Bodies for Liquids:

Flow Range: From 1 to 9080 LPM with accuracy of ±0.5% FS.
Connections: ANSI 150# flange with varying sizes from 0.75" to 6".
Body Length: Ranges from 127 mm to 240 mm.
Max Pressure Drop: 250 mbar.
Material: Stainless steel construction.

2. Displays for Turbine Bodies:

Features: Large LCD display, selectable units for total and flow rate, password protection, and optional output signals.
Power: Lithium battery with a six-year life span.
Specifications: IP65 rated casing, operating temperature from –20 to 80°C.

3. Mass Flowmeters and Controllers:

Flow Range: From 0.01 mL/min to 1000 LPM.
Accuracy: ±0.8% of reading +0.2% full-scale.
Features: Integrated PID, fast response time, and dynamic display for flow rate, pressure, and temperature.
Materials: Constructed from stainless steel, Viton, and other durable materials.

4. Mixers:

Types: Digital reversing mixers, IKA RW 20 Digital Dual-Range Mixer, EUROSTAR Digital Mixers.
Features: Maintenance-free motors, overload protection, and adjustable speed ranges.
Applications: Suitable for mixing various viscosities and volumes, with options for wireless control and integrated temperature sensors.

Conclusion: The document provides comprehensive options for flow measurement and mixing solutions, catering to a wide range of industrial applications with detailed specifications and customization options.

Overview: This document provides detailed specifications and product information for various laboratory equipment, including pipettors, petri dishes, inoculating loops, and water baths. It includes product features, specifications, catalog numbers, and pricing details.

Pipettors:

Volume ranges from 5 µL to 10,000 µL with varying accuracy and reproducibility percentages.
Features include programmable presets, multiple pipetting functions, and a large color display.
Autoclavable components and soft-touch tip ejectors are highlighted.

Petri Dishes:

Available in various sizes and configurations, including with or without absorbent pads.
Sterilized by gamma irradiation for immediate use.
Convenient stacking features to prevent tipping.

Inoculating Loops and Needles:

Made from platinum wire with iridium or rhodium for durability and precision.
Available in various sizes and configurations, including insulated and non-insulated handles.
Designed for semi-quantitative bacterial counting and culture transfer.

Water Baths and Circulators:

Digital and programmable models with precise temperature control and safety features.
Bath capacities range from 2 L to 28 L with various temperature ranges and stability specifications.
Features include advanced PID algorithms, touch-screen displays, and optional force/suction pumps.

Additional Products:

Sterilized sampling bottle assemblies for biopharmaceutical applications.
Oxford Bacti-Cinerator for rapid sterilization of loops and needles.
Thermo Scientific Nalgene sterile media bottles for long-term storage.

Contact Information: For further assistance and product inquiries, contact Cole-Parmer via phone, fax, or email.

Specifications
Temperature control is managed by PID algorithms with a Pt RTD sensor, ensuring precise temperature regulation. The heater wattage is 2000 W, and the maximum pump flow is 20 L/min. Wetted materials include stainless steel and polymers, with a low-level cutoff feature for safety.

Product Features
The PolyScience® Cooling/Heating Circulating Baths feature advanced PID algorithms for responsive temperature control. The WhisperCool™ technology optimizes compressor and evaporator performance, reducing energy consumption. The baths have a backlit digital display and a waterproof control panel that swivels 180° for easy viewing. Different controllers offer varying temperature ranges and pump speeds, with the Performance Programmable Controller providing unlimited time/temperature programmability.

Bath Capacities and Specifications
Baths are available in various capacities, ranging from 7 L to 28 L, with temperature ranges from -40°C to 200°C. The baths feature force/suction pumps suitable for both open- and closed-loop applications. The Performance Digital Controller models offer precise temperature stability of ±0.005°C.

Stirrers and Hot Plates
Cole-Parmer® offers a range of stirrers and hot plates, including analogue and digital models. The advanced analogue hot plates feature an LED temperature indicator scale, while the digital models provide precise temperature control. Optional digital temperature controllers are available for enhanced accuracy.

Lab Jacks and Stir Bars
Jiffy-Jack® Lab Jacks are available in aluminum and stainless steel, supporting various load capacities. Mono-Mold® and Slim-Line® stir bars are designed for efficient mixing, with options for different sizes and configurations.

Vortex Shakers
Vortex-Genie Shakers offer high-speed touch mixing with variable speed control for different mixing intensities. The shakers are designed to remain stable on benchtops and come with adaptable platforms for various applications.

Overview of Vortex-Genie Shakers:
The document provides detailed specifications and features of various Vortex-Genie shakers, including the Vortex-Genie 2T, Digital Vortex-Genie 2, and Vortex-Genie Pulse Shaker. These shakers are designed for laboratory use, offering both touch and hands-free operation modes, with varying timer ranges and speed capabilities.

Vortex-Genie 2T Shaker:
This model supports touch mode shaking for 1 to 60 seconds and hands-free mode for 1 to 60 minutes. It includes a pop-off cup and a 7.6-cm platform, making it versatile for different laboratory applications.

Digital Vortex-Genie 2 Shaker:
Features an extended timer range, allowing shaking from 1 to 99 seconds in touch mode and 1 to 99 minutes in hands-free mode. It includes a digital display for enhanced accuracy and reproducibility.

Vortex-Genie Pulse Shaker:
Offers a unique pulsing action for more aggressive mixing, ideal for applications requiring more vigorous agitation. It is fully programmable with digital control and display of speed and time.

Specifications and Accessories:
The document lists various specifications such as speed range (500 to 3000 rpm), power requirements, and platform dimensions. It also details optional accessories like tube holders, platform kits, and replacement parts to customize the shakers for specific needs.

Cole-Parmer Microplate and Reciprocating Shakers:
These shakers are designed for mixing micro-volumes and a variety of vessels. They feature digital displays, adjustable speeds, and built-in timers for precise and repeatable results.

Additional Laboratory Equipment:
The document also includes information on other laboratory equipment such as pH/Ion meters, turbidimeters, and homogenizers, highlighting their features, specifications, and applications.

Specifications
Models 98965-43 through -48 include data logging software and USB cable, while models 98965-49 through -51 also include control software. The accuracy is ±1% full-scale with a resolution of 0.1 cp for viscosities under 10,000 cp and 1 cp for viscosities 10,000 cp and above. Reproducibility is ±0.2%. The temperature probe is a 100 Ω Pt RTD, ranging from 0 to 100°C. Power requirements are 100 to 240 VAC, 50/60 Hz.

Applications
Viscosity measurement for antibodies and formulation processes.

Analytical Balances
Cole-Parmer Symmetry PA and PT balances offer internal and external calibration options, with capacities ranging from 120 g to 15,000 g. They feature USB and RS-232 interfaces, a sealed keypad, and a splashproof design. The balances support various weighing modes and have fast stabilization times.

OHAUS Adventurer Balances
These balances provide advanced weighing functions, GLP/GMP compliance, and connectivity options with two USB ports. They feature a color touch screen and illuminated level indicator for easy operation.

Weighing Dishes
Various types of weighing dishes are available, including hexagonal, round, and polystyrene designs, suitable for different applications and resistant to various substances.

Cleanroom Standards
Cleanroom classes are determined by particle count per unit volume, with standards ranging from ISO Class 1 to Class 100,000. Personal protective equipment and cleaning supplies are essential for maintaining these standards.

Gloves
KimTech Pure G3 Sterile Critical Nitrile Gloves and Microflex Cleanroom Gloves are designed to protect sensitive samples and eliminate contamination, complying with ISO standards.

Overview: This document provides detailed specifications and product information for various cleanroom supplies and equipment, including gloves, boot covers, coveralls, tacky mats, swabs, wipes, cleaning products, and air samplers. Each product is described with its compliance standards, material composition, and intended use in controlled environments.

1. Cleanroom Gloves:

Latex and Nitrile Gloves: Available in ISO Class 4 and 5, with sizes ranging from small to X-large. Latex gloves have a thickness of 6.3 mil, while nitrile gloves are 5.2 mil thick. Each bag contains 100 gloves.

2. Boot and Shoe Covers:

DuPont™ Tyvek® Boot Covers: ISO Class 4 compliant, with PVC soles and a length of 15 inches. Not CE certified for chemical protection.
Pro/Clean® Boot Covers: ISO Class 5 compliant, featuring elastic tops and ankles for easy wear.
Polypropylene Shoe Covers: Made from 100% spunbond PP, available in regular or skid-free soles.

3. Coveralls:

MicroGuard CE™ Coveralls: ISO Class 5 compliant, made from nonwoven polypropylene with microporous film for breathability. Available with elastic wrists, ankles, hoods, and boots.
GammaGuard® Sterile Coveralls: ISO Class 4 compliant, offering sterility assurance and low linting. Features bound seams and elastic wrists and ankles.

4. Tacky Mats:

Wearwell® PermaTack Tacky Mats: Reusable mats with a permanently tacky surface to trap particles. Available in various sizes and colors.

5. Swabs and Wipes:

TEXWIPE® Cleanroom Swabs: Available in fabric and foam types, suitable for cleaning small surfaces and validation processes.
Kimberly-Clark® Critical Task Wipes: Low-lint, absorbent wipes for delicate surfaces, available in single and two-ply options.

6. Cleaning Products:

Alconox® Cleaning Products: Biodegradable and concentrated cleaners for various materials, ensuring no interfering residue.

7. Air Samplers:

SAS Super 100 Digital Microbial Air Samplers: Designed for cleanroom applications, with preset and programmable sample volumes.
MAS-100™ Eco Air Sampler: Portable and accurate air sampler with programmable sampling delay and compliance with ISO guidelines.

Contact Information: For further assistance and product selection, contact Cole-Parmer via phone, fax, email, or live chat.

Overview: This document provides a comprehensive catalog of laboratory supplies essential for research, scale-up, pilot operations, and quality control. It includes a variety of products such as carboys, bottles, beakers, vials, syringes, and more, each with specific features and pricing details.

Carboys: The catalog lists various types of carboys, including Bio-Simplex™ Carboys, High-Purity EZ Top® Container Closures, Thermo Scientific™ Nalgene™ Carboys, and Cole-Parmer® Economical Heavy-Duty Carboys. Key features include autoclavability, chemical resistance, and leakproof designs. Sizes range from 10 to 50 liters, with options for spigots and different cap materials.

Bottles & Beakers: The document details a range of bottles and beakers, including PYREX® Brand Media Bottles and Cole-Parmer® Tri-Corner Beakers. Features include durable designs, chemical resistance, and autoclavability. Capacities range from 25 mL to 10,000 mL, with various cap options for secure sealing.

Vials & Syringes: A selection of vials and syringes is available, including Class A Sample Glass Vials and BD™ Disposable Syringes. Vials are offered in clear and amber glass, with different cap and liner options. Syringes are available in Luer-Lok and slip-tip versions, suitable for sample withdrawal and small-volume injections.

Graduated Cylinders: Cole-Parmer® Serialized Class A Graduated Glass Cylinders are highlighted, meeting ISO 9000 requirements. They are available with reports of traceability and calibration, ensuring accuracy and reliability for laboratory measurements.

Contact Information: For further assistance and product inquiries, customers are encouraged to contact Cole-Parmer via phone, fax, or email. The catalog also directs users to the Cole-Parmer website for a broader range of products and the latest pricing information.

Cylinder Specifications:
Various cylinders are calibrated 'To Deliver' with capacities ranging from 10 to 2000 mL, each with specific tolerances and catalog numbers for ordering.

Boxes and Lids:
HDPE multipurpose boxes are available in various sizes, with optional lids that double as trays. They can be configured with colanders for easy straining.

Sampling Bags:
Available in different sizes and types, including stand-up bags with white labeling areas and high-temperature bags suitable for samples up to 102°C. They are designed for easy sealing and puncture resistance.

Cable Ties:
Solid-design cable ties made from nylon and polypropylene are available, offering high tensile strength and resistance to various environmental conditions.

Forceps and Tweezers:
Various types of forceps and tweezers are available, including stainless steel and nylon options, with features like serrated tips and autoclavability.

Sterile Sampling Tools:
Includes scoops, spoons, and spatulas made from polystyrene and polypropylene, designed for single use and sterilized for contamination prevention.

Quick-Disconnect Couplings:
CPC™ Polysulfone couplings provide secure, leak-free connections with easy operation and intuitive programming.

Pump Systems:
Masterflex® L/S® Digital Miniflex® Pump Systems offer accurate flow control in a compact design.

Single-Use Liners:
Designed for tanks to allow near-total drainage and contain drips, made from LLDPE and pyrogen-free materials.

Catalog excerpts

P R O C ES S I N G Meeting your needs from Laboratory to Fill/Finish fluid transfer | fluid path filtration | testing & analysis process monitoring | labware & supplies 020-8574-7556 Expert product assistance Katie, Application Specialist Find >100,000 products at ColeParmer.co.uk

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Cole-Parmer: delivering accurate, precise fluid handling for biopharmaceutical/pharmaceutical customers for more than 30 years • 100% compliance rate with customer quality audits • 99.7% accuracy on recommended products for customer needs • 3% satisfaction rating among biopharmaceutical 9 customers when doing business with Cole-Parmer • ertificates of material compliance available on more C than 2,000 products. In addition, we offer product lot control, product documentation, animal-derived ingredient documentation, change control notifications, and more to keep you compliant with industry standards...

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Fermentation At the heart of your process, fermentation creates the proteins for your therapies. Careful monitoring and precise addition of media and other additives are essential for effective growth. Cole-Parmer has what you need for optimal output. Pre-Seed Reaction Vessel Find these products! Look for these key codes in the Table of Contents on page 3 Tu Pump System Vent Filter Seed Reaction Vessel Sample Bottle Harvesting Pump System Production Reaction Vessel Contact us for the full range of products and latest prices! Fax: 020-8574-7543 [email protected] www.coleparmer.co.uk

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Harvesting From washing to buffer injection to filtering, the steps in harvesting begin to separate the protein from the cells. Look to our pumps for fluid transfer capabilities as well as single-use lines between filters and vessels. Depending on your production scale, our filtration products may also provide critical performance in your process. Pump Retentate Fermentation Buffer Washing Tank Pump Pump Washing Tank Storage Vessel “Gone are the days when upstream scientists could modify their process and ignore the repercussions in manufacturing.” —Cell Culture World, Congress 2016 Conference...

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Purification Separate your final product from all remaining contaminants and effluvia. Concentrate and refine the proteins to prepare them for final product fill/finish. Pressure Sensor Chromatography Pressure Sensor Filtrate Vessel Fill / Finish Other Processes Whether for quality control, process monitoring, research and development, or worker and process environment protection, look to Cole-Parmer for your needs. Can’t find the exact item you need in this catalog? Visit ColeParmer.co.uk for more options! Fluid Transfer Masterflex® L/S® Pumps . . . . 5–13 Process Monitoring Pm Pressure . ....

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More @ ColeParmer.com! Fluid Transfer Move fluid with confidence and precision Pumps to meet your exact specifications from development to media preparation to final fill/finish Masterflex® and Ismatec® pump systems and tubing for transfer, additions, filtration, and more . . 5–29 Syringe pumps offer accurate microflow rates for better R&D results . . . . . . . . . . . . . . . 30–31 Meet filtration pressure demands with gear or piston pumps . . . . . . . . . . . . . . . . . . . 32–36 Get steady, pulseless flow with disposable single-use pump heads . . . . . . . . . . . . . . . Process Monitoring...

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Masterflex® Tubing Pumps Flow Ranges B/T® Need help selecting? Call the experts! 020-8574-7556 Masterflex® L/S® Digital Miniflex® Pump Systems - Flow range of 0.004 to 315 mL/min (depending on model and tubing size selected) - Tubing calibration function ensures accuracy - Open-head sensor stops drive when pump head is opened - Remote control via 25-pin connector on back of drive - Automatic tubing retention makes tube loading quick and easy Compact, stackable pump with durable ABS housing is easy to wipe down and keep clean. The Miniflex pump head features a wide occlusion angle that prevents...

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Masterflex® |Tubing Pumps 10 Flow Ranges P 10.00001 to 3400 mL/min L/S® - Flow rates: 0.06 to 3400 mL/min - Easy up-front control of speed, direction, and start/stop - Reversible motor—purge tubing before or after pumping; ✓ Epoxy resin delivery ✓ Bulk container pump ✓ Coolant/recirculation pump ✓ FDA tablet coating ✓ Adhesive resin delivery ✓ Packaging process pump ✓ Fermentation additions B. Precision washdown modular drive with washdown wall-mount controller Masterflex® L/S® Precision Variable-Speed Modular Pumps pump fluid in either direction - Three-digit LED display shows motor rpm—confirm...

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42 LPM Need help selecting? Call the experts! 020-8574-7556 Masterflex® L/S® Variable-Speed Digital ■ Brushless, maintenance-free motor provides ±0.1% speed control accuracy with 6000:1 turndown ratio ■ Bright graphical LCD offers easy programming and four operating modes ■ Ensure dispensing accuracy with antidrip function ■ Get more accurate dispensing with preprogrammed calibration ■ Change based on your needs—drives accept all L/S pump heads for more pumping versatility ■ Programmable, reversible motor accepts up to four pump heads ■ Choose how you want to dispense: volume, copy cycles, or...

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Masterflex® |Tubing Pumps 10 Flow Ranges P 10.00001 to 3400 mL/min L/S® applications ✓ Pumping buffer solution ✓ Filling/emptying media bags : ✓ Sterile filtration; sterile fluid transfer ✓ Filtration Masterflex® L/S® Digital Console Process Pumps Transfer, dispense, and meter in lab, process and washdown environments MasterFIex" - IP66 and NEMA 4X rated. Sealed housing and sealed keypad are protected from dust, water, and chemicals in the washdown environment— simply hose down to clean. - Programmable, reversible motor accepts up to two pump heads and offers remote functionality - Flow rate:...

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Need help selecting? Call the experts! 020-8574-7556 Masterflex® L/S® Digital Modular Three dispensing modes and precision low-maintenance motor Dispensing Pumps - Graphical LCD shows four operating modes: continuous run, timed dispense, copy dispense, volume dispense - Antidrip function ensures dispense accuracy - Brushless, maintenance-free motor offers ±0.1% speed control - Remote control capabilities: speed, direction, start/stop/prime, tach output A. Modular Drive with Benchtop Controller - Stackable, splash-resistant ABS plastic controller housing is IP33 rated; drive housing is epoxy finished...

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