Spectrum MINOCYCLINE/RIFAMPIN CATHETER
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Spectrum MINOCYCLINE/RIFAMPIN CATHETER - 1

Each year in the United States tens of thousands of patients will contract a catheter-related bloodstream infection (CRBSI). The consequences associated with this type of infection are significant: • 12%–25% mortality rate1 • U.S. $11,9712–$56,0001 average cost per line infection • U.S. $296 million–$2.3 billion in annual expenses1 the right combination Minocycline+rifampin is the most rigorously studied and synergistic combination of antibiotics available on a catheter for reducing CRBSIs through two distinct mechanisms of action. Unlike most antibiotics, this combination has the ability to penetrate the biofilm that forms on all indwelling catheters.3 Unmatched Evidence Two decades of evidence, including more than 21 peer-reviewed studies and 4 meta-analyses, confirm minocycline+rifampin catheters are the most effective tool available to provide broad-spectrum protection against gram-positive, gram-negative and fungal infections5, 6 in both short- and long-term use. It’s evidence of protection no other process or technology can match. Power Injection** Lumen Information* Important Information Contraindications Do not use on patients with known allergy or history of allergy to tetracyclines (including minocycline) or rifampin. Minocycline and rifampin are agents that do not induce any genotoxic risks except a possible teratogenic effect in pregnant women. We therefore do not recommend the use of Cook Spectrum and Spectrum Glide catheters in pregnant women. More than 10 years of clinical use has shown no evidence that M+R catheters lead to bacterial resistance, and a seven-year study of over 500,000 catheter days confirms these results.7 A separate study indicates that a facility using M+R catheters may have shown a decrease in vancomycin usage.8 4.0 Double (SDLM - Soft Polyurethane) Flushing CVC After Placement When flushing the lumens and checking for blood return, flush remaining saline through the caps/lumens of CVC to ensure all blood has been cleared. In a challenging clinical environment, a hospital that switches to M+R catheters may expect to see a decrease in CRBSI rates, attributable mortality and CRBSI-related costs. Even high-performing hospitals can switch to Spectrum to drive incremental improvement in CRBSI rates and may still achieve substantial reductions in mortality and expenses. Tray components† include: • Ch-SS+ (AGB+) Gram Negative ANALYSIS OF TYPES OF INFECTION5 INFECTIONS PER 1,000 CATHETER DAYS medication delivery, acute hyperalimentation medication delivery Blood work should be done through the #1 distal lumen, as it is larger and has a greater flow rate. Temporarily stop infusions and clamp middle and proximal ports to avoid contamination of blood when withdrawing samples from the distal lumen. CT printed on distal lumen. Power inject contrast media through distal lumen only. Maximum flow rates printed on lumen clamp. Cook Spectrum® central venous catheter with hydrophilic coating and Luer-lock end caps § Safe-T-J® double flexible-tipped wire guide with cm markings EchoTip® echogenic introducer needle Catheter insertion checklist BakSnap® safety syringe (2) Prefilled sodium chloride syringes 25 gage needle 22 gage needle FEP catheter introducer needle Transducer tubing Dilator Lidocaine and lidocaine label Filter straw Tinted ChloraPrep® One-Step Full-body fenestrated drape with clear window Gauze sponges Disposable safety scalpel Straight needle with suture or curved needle with suture and needle holder Disposable syringes Needleless injection caps Locking sharps container Movable suture wing | | Also available with: Spread wings of rubber clamp and position on catheter in appropriate position to ensure proper tip location. Safer Method of CVC Insertion Figure 2 • Cap, mask with face shield, and gown Snap rigid fastener onto catheter clamp. Gram Positive Triple Lumen/ Five Lumen Movable Suture Wing Uniquely designed to support your process bundle. INFECTIONS PER 1,000 CATHETER DAYS whole blood or blood product delivery and sampling, any situation requiring greater flow rate, CVP monitoring, medication delivery, power injection** **FDA cleared for power injection in 7, 8, 9, 10 Fr power-injectable CVCs only. Power inject contrast media through distal lumen only. *In accordance with ISO 10555-3, lumens of each device were flow tested using 20˚C purified water, with a head height of 1,000 mm. Please see package insert for complete Instructions for Use. medication delivery, acute hyperalimentation Double Lumen whole blood or blood product delivery and sampling, any situation requiring greater flow rate, CVP monitoring, medication delivery, power injection** *Excludes special lengths, pigtail, 4 Fr, 5 Fr and 10I_ULM7RD_REV.2 Fr catheters. 10.0 Five Lumen Power-Injectable Catheter Measurement* Catheter length should be measured from the tip to the point between two thin, black lines located 1.5 cm below the hub. Hydrophilic Coating Spectrum catheters feature a hydrophilic coating that activates upon insertion. Catheters may be wetted with saline prior to placement. Preflushing Flush all catheter lumens and injection caps prior to catheter placement. Average Pressure at Maximum Flow psi Slide Clamps To ensure the appropriate lumen is completely clamped off, use extra care to confirm the clamps are fully engaged in the closed position. Maximum Flow Rate mL (cc)/sec Hospital-Approved Injection Caps Work with your hospital infection control team to learn about your hospital’s injection caps and follow manufacturers’ recommendations for proper use, care and maintenance of your caps. Failure to comply with these recommendations can lead to catheter malfunction and/or increased risk of infection. Worth switching Equivalent gage Approximate Flow Rate mL/hr Minimum Lumen Volume mL tray configured to meet AHRQ, CDC, IHI, Joint Commission, OSHA and SHEA guidelines for patient safety. The Agency for Healthcare Research and Quality (AHRQ) recommends ultrasound for CVC placement as one of 11 practices to improve patient safety based on the greatest strength of evidence.9 Extensive dimpling on the EchoTip needle’s distal tip dramatically enhances visibility and maximizes the benefits of ultrasound. injection available on 7, 8, 9 & 10 Fr power-injectable catheters. 4, The CDC partially funded a study  5 to determine relative efficacy of 2nd generation CH-SS+ catheters and Spectrum M+R catheters. After 46 months and more than 23,000 catheter days, investigators found overall catheter-related bloodstream infection rates to be lower when the M+R-impregnated catheters were placed. In addition, there was a lower incidence of gram positive, gram negative and fungal infections with Spectrum. caps only available on 7, 8, 9 & 10 Fr CVCs. catheter lengths only. Figure 3 Secure catheter to patient by suturing catheter clamp and fastener together to the skin using side wings to minimize risk of catheter migration. PR PROCESS AGB+ is a registered trademark of Arrow International Investment Corp. BakSnap is a registered trademark of DuoProSS Meditech Corporation. ChloraPrep

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