Martin Heitma,e. | S*s Manage'

Brief Snapshot CORE develops and produces thermal sensing solutions for the clinical, industrial and research markets Founded in 2009 as an ETH Zurich spin-off Located in Zürich, Switzerland State of the art sensor lab for 20 M sensor capacity annually Expert team of physiologists, clinical research specialist, data scientists, Machine learning engineers to create human vital based health and fitness insights CORE sensors have been validated in over 100 peer reviewed research publications

Skin temp. is strongly influenced by environmental changes Skin temperature is not representative of core body temp Thermoregulation: Different temp. changes at the extremities and at the core

CORE’S solution overcomes these issues using heat flux Heatflux based measurement compensates environmental influences. Thermoregulatory changes can be detected by changes in the heatflux.

Partnering with Hospitals → Algorithms, Development, and Validation Prof. Dr. Jens Eckstein Prof. Dr. Johannes Mathis Prof. Dr. Dominique Bettex Circadian Cycle Study Sleep Study Fever Study Fever Study Prof. Dr. Christoph Berger Prof. Dr. Amselm Bräuer Baby Fever Study Children Fever Study Firefighter Study Stroke Study

Some of our happy researchers → Partnering with world-renowned institutions conducting studies with our device. We understand the different needs of various use-cases.

Applications of Continuous Core Body Temperature Monitoring → Our technology is used in many scenarios Sleep and Circadian Rhythm Monitor and analyze sleep patterns and circadian rhythm Determine ideal performances and prevent overheating Women’s Health Occupational Health Enabling precise Menstrual cycle monitoring, and aiding in menopause management Prevent heat illnesses and de hydration. Improve workers performances.

CORE Calera Specifications • Compact: 50mm x 40mm x 8.35mm • High accuracy: Individually calibrated devices, ±0.30 °C • Rechargeable lithium-polymer battery (via USB cable supplied) • Battery life: 6.5 days • Continuous measurements for up to 6.5 days • Data stored internally in the device • Waterproof up to 1.5m and sweat proof

During medium to high physical activity, CORE Calera® needs to be paired with a heart-rate monitor for increased accuracy. For the best accuracy the device should be worn on your rib-cage underneath your chest. If you do not have or need a heart rate monitor, you can also use one of our reusable chest straps. For increased comfort, the device can be attached with medical adhesive patches. They are waterproof and one patch can be used for up to 6 days depending on the person and activity.

Data ManagementFor CORE Research *N Cora '3tidy Tertfipecjrture Bettereft TmI ivO.S.lrcOl Sifp K*neieig tnter fractional device lOi to filter, separated v«vth 4 comma. Colon can be emitted1f* ample. Aft: *ft. DC. bdl2 BLE itanglet; 1 Dfvieet f#l#irt*iSfc 1 Devictl found: 7 UtHrties Download Update Claud Device groups Device liete Dwnlwd reedy j 5d >ieie j Ge* device info Set subject info EKf£4*tr HPM Pair HRM Algorithm mode Advanced setting* 5ync from QMS Devices $ta|us Control multiple devices simultaneously: • Start/stop measurements • Dowload data in easily accessible .csv file • Update firmware...

App The Calera Research app lets you control and monitor your Calera device for research Key Features • Device Control • Data Download • Connection Stability • Live Monitoring calera SKIN HEART RATE Rename Sensor User Settings Standby mode Algo mode Switch upon HR availability Heart rate monitor Logging Mode

SoftwareProfessional tool for convenient and reliable data collection Key Features • Devices Management • Data Collection and Export • User settings and metadata management • Heart Rate Monitor pairing

CloudCentralized command center to view your devices Key Features • Multi-Device Access • Real-Time Data Visualization • Data export

Search For Tag or Select Date Range CloudCentralized command center to view your devicesKey Features • Multi-Device Access • Real-Time Data Visualization • Data export Heart Hate Gray background color indicates higher uncertainty of the displayed temperature values. A colored background indicates a tagged region.

Raw Data AccessEasily analizable and interpretable data: • CSV excel file 1 second resolution Skin temperature Heat flux* Core Body Temperature 3D accelerometer Heart rate (paired device) • Remote support from our thermal experts • Study protocol design • Data interpretation support

CRS [CALERAresearch Sensor] was considered valid (compared to TGi [ingestible pills]) and reproducible in estimating TCORE in both sexes at various intensities of cycling exercise in the heat. Validation Studies → Validity and reproducibility of the CORE Calera Sensor to estimate core temperature at different intensities of a cycling exercise in the heat Core temperature responses (TCORE), measured by CALERAresearch Sensor (TSENSOR) and gastrointestinal capsules (TGi), during the experimental protocol. By William Martins Januário, Natália Franciele Lessa, Ana Júlia de Oliveira Schittine, Emille...

The predicted core temperatures (Tcore [from the CORE device]) were significantly correlated with the tympanic temperatures (Ttym) (r = 0.89, p < 0.001). Validation Studies → A Novel Non-Invasive Thermometer for Continuous Core Body Temperature: Comparison with Tympanic Temperature in an Acute Stroke Clinical Setting. The estimated core temperature (Tcore) is plotted against the tympanic temperature (Ttym) for each measurement. By Miloš Ajčević; Alex Buoite Stella; Giovanni Furlanis; Paola Caruso; Marcello Naccarato; Agostino Accardo and Paolo Manganotti. “Comparing the Limit of agreement LOA...

CORE Research used in Sports Studies → Effect of cold ambient temperature on heat flux, skin temperature, and thermal sensation at different body parts in elite biathletes By Thomas Blokker, Ellias Bucher, Thomas Steiner & Jon Peter Wehrlin How Elite Athletes with a Spinal Cord Injury Sweat during Exercise —An Exploratory Study By Anneke Hertig-Godeschalk and Claudio Perret Mask vs. tent: effect of hypoxia method on repeated sprint ability and physiological parameters in cyclists By Aldo A. Vasquez-Bonilla, Daniel Rojas-Valverde, Joan M. Feliu-Ilvonen, Rafael Timón & Guillermo Olci