Corning Cell Culture Surfaces ® The right surface for every cell

The Right Surface for Every Cell Corning’s history in cell culture surfaces extends back more than 100 years. During that time, we have introduced numerous new surface technologies, including PYREX® glass, Matrigel® matrix, BioCoat™ pre-coated cultureware, and synthetic ECM mimetic peptides. In addition to non-treated and tissue culture-treated Corning® and Falcon® polystyrene cell culture vessels, Corning offers a number of technologies for enhanced binding and growth of specialized and fastidious cell types in low- and non-serum media environments. These technologies include functional, structural,...

Extracellular Matrices and Biologically Coated Surfaces Corning provides a wide range of animal, human, and synthetic matrices to support cell attachment, propagation, differentiation, and migration. Corning’s extensive experience purifying ECMs and other proteins, rigorous quality processes, and ISO 9001 manufacturing, results in high quality, consistent vialed and pre-coated products. Corning® Matrigel® Matrix – the Original, Trusted Extracellular Matrix Corning Matrigel matrix is a solubilized basement membrane preparation extracted from the Engelbreth-Holm-Swarm (EHS) mouse sarcoma, a tumor...

Corning® BioCoat™ Cultureware Corning has extensive experience in thin film coating technology and offers highly consistent and biologically functional pre-coated surfaces in a wide range of vessel and microplate formats. Our stringent quality control measures and documentation are designed to meet the needs of drug discovery and biotechnology applications. Coating is conducted in a highly controlled, cGMP, aseptic manufacturing environment to ensure lot-to-lot consistency, reproducibility, and contamination control. In addition to off-the-shelf BioCoat products, Corning’s custom coating service...

Characteristics of Coated Surfaces Corning® Extracellular Matrix Products Corning® Cell-Tak™ Cell and Tissue Adhesive Corning PuraMatrix® Peptide Hydrogel Suitable as a thin coating to enhance the attachment of cells to plastic and glass surfaces Can be used for establishment of primary cultures, in situ hybridization, immunoassays, microinjection, immunohisto chemistry, and patch clamping. Synthetic matrix enabling researchers to develop micro environments. Applications include primary cell differentiation, cell migration/ invasion, angiogenesis assays, and in vivo cell engraftment for analyses...

Characteristics of Coated Surfaces Corning® Collagen Products Rat Tail Collagen I, sterile filtered Rat Tail Collagen I High Concentration, sterile filtered Suitable for a thin layer on tissue culture surfaces to enhance cell attachment and proliferation or as a gel to promote expression of cell-specific morphology and function. Commonly used to culture endothelial cells, hepatocytes, muscle cells, and a variety of other cell types. Bovine Collagen II, sterile filtered High concentration provides greater matrix stiffness and scaffold integrity; suitable for 3D cell culture applications. Suitable...

Corning® Collagen Products (continued) Corning BioCoat™ Gelatin Found in several connective tissues including the dermis of young organisms, human skin, and cornea. It can be used as a thin coating on tissue culture surfaces to promote cell attachment and to modulate cell behavior. A ubiquitous component of the basement mem brane. The sheet-like matrix is found in close proximity to epithelial, muscle, and nerve cells. Plays a role in the reg ulation of cell growth, differentiation, and tissue formation. A ubiquitous component of the basement membrane. The sheet-like matrix is found in close...

Corning® Laminin Products Mouse Laminin, sterile filtered Laminin/Entactin Complex (High Concen tration), sterile filtered Ultrapure Laminin (entactin-free), sterile filtered Poly-D-Lysine/ Laminin Poly-L-Ornithine/ Laminin Suitable as a thin coating on tissue culture surfaces or as a soluble additive to culture medium. It has been shown in culture to stimulate neurite outgrowth, promote cell attachment, chemotaxis and cell differentiation. A highly consistent ECM formulation that enables the study of 3D cell differentiation and functionality, and can be used as a consistent substitute for Corning...

Corning® PureCoat™ and Advanced Surfaces Corning is a leader in cell culture surface technology, with a long legacy of developing new surfaces with expanded capabilities. These surfaces enable cell biologists to develop new applications, such as defined expansion and differentiation of stem and progenitor cell types and tools for 3D spheroid generation and screening. Corning PureCoat ECM and Defined Surfaces Corning PureCoat ECM and advanced surfaces contain biologically active, animal-free peptides that have been rationally designed to mimic the cell attachment process and motifs of native ECM...

Corning PureCoat ECM Mimetic Fibronectin Peptide Defined, Xeno-free MSC Kit with Human Origin Coating Matrix After Passage 5, 10X Objective Comparable cell growth, morphology. Bone marrow-derived hMSCs cultured in a defined and xeno-free media on the Corning® PureCoat™ ECM mimetic Fibronectin peptide surface exhibit a tight and compact morphology and are comparable to the human origin matrix coating after 5 passages. Human-origin matrix Fibronectin mimetic hMSCs cultured on Corning PureCoat ECM mimetic fibronectin peptide displayed a cell surface marker profile characteristic of hMSCs. Data shows...

Corning® PureCoat™ rLaminin-521 Cultureware The recombinant Laminin-521 cultureware combines BioLamina’s expertise in recombinant Laminin expression with Corning’s extensive line of vessels and proprietary surface coating technologies. This agreement brings robust, scalable, animal free, pre-coated cultureware solutions to the emerging stem cell processing market, enabling clinical researchers to scale-up effectively and mitigate risk. w Maintains hPSC pluripotency for a minimum of 10 passages with a high expansion rate Highly consistent and controlled monolayer cell growth Proven performance...