Continuous Patient Monitoring Anytime, Anywhere Introduction CardioWatch System for Research

CardioWatch solution Real time cloud-based research platform, enabled by the world’s most advanced multi-sensor bracelet for continuous monitoring of vital signs, with unrestricted access to raw data for AI and ML development CardioWatch Bracelet continuously monitors and transmits health data Corsano App is very easy to use and is remotely configurable for a study by researcher Corsano Health Cloud utilizes best practices security, GDPR and HIPAA Corsano Research Portal offers full flexibility to create studies, set parameters and export data

Bracelet Measurements enabled from continuously streaming data USER-FRIENDLY Superior Patient Compliance • Comfortable and aesthetic • Validated stretch bands • Long battery life • Water-resistant • Continuous acquisition of quality data (no single data snapshot) • Secure and private • Flexible patient workflow Pulse Rate CE-MDR Certified 510(k) Pending Core Body Temperature Blood Pressure Activity & Sleep

How Corsano CardioWatch differentiates from other wearables and platforms Medically Certified • CE-MDR Medical Certification • FDA Pending (Ql/24) • Validated Vital Sign algorithms • Proven platform in clinical research and patient care • State-of-the-art biomarker development: Hypertension, Cardiac Arrest, Immune Oncology, Frailty, Scepsis Patient Centric • Smallest and lightest patient bracelet in the world • Long battery life • Single purpose device for longterm patient monitoring • Very easy to use • Proven with 10’000+ patients, incl. Senior and Pediatric patient populations • Acute and...

with headquarters in The Hague, Netherlands Clinical Trials The Hague, Netherlands Geneva, Switzerland devices produced

System & Security System & Security Corsano ensures reliable performance and scalability while adhering to industry recognized best practices for Data Security and Privacy 6

GlassFish Math Engine Partner Clouds System & Security Cloud System AWS Elastic Load Balancers Authentication Server User Data User Data Management Web UI Server Backup Server System Monitoring Cold Health Data Health Data Management Corsano Cloud System 7

System & Security Penetration Testing

Clinical Validation Corsano’s vital signs algorithms, derived from real-world patient data, are rigorously validated and reviewed in scientific journals 9

IgJ BPM Clinical validation with CCN/AMC Oct 2020 A RR Intervals II validation with CCN/AMC Nov 2020 Activity type, sleep, I cadence. Validation VSO ELAN, Nov 2019 H+ Respiration Rate. Haaglanden MC MC, December 2020 Blood Pressure (Pulse Wave algorithm, trends algorithm and calibration) Reinierde Craaf Q1 2023 Cardiac Arrest. Radboud & Erasmus MC, Q3 2023 Germany ^ Class II CE Certified VP AFib Algorithm Preventicus May 2018 □ Clinical trial AF Burden Validated PPG Based Sleep, July 2017 Clinical Trial, CFIU Saint Pierre, Jan 2021

Validation according to ISO 81060-2:2019 and AAMI/ESH/ISO Bland Altman Bland Altman *Non-lnvasive Blood Pressure (NIBP)

Research Accelerate clinical trials and generate unparalleled insights to develop life-saving therapies faster

Reduce trial execution time & cost while increasing commercial value REDEFINED CLINCAL DEVELOPMENT MODEL REDEFINED SAFETY MONITORING REDEFINED COMMERCIALIZATION RECRUITMENT CHALLENGE MITIGATION Increase Recruiting Geography Support Diversity & Inclusion goals OPTIMIZED PATIENT POPULATIONS Triaged Patients to Exclude Non-responders Potential Use of Historical Data Control Arm STREAMLINED CLINICAL OPERATIONS Reduce Site Visit Frequency Immutable Sensor Data Improves Quality Reduced Patient Data Processing Time PHARMACOVIGILANCE Shift to Predict to Avoid from Track to Report Improve Product Risk/Benefit...

FLEXIBLE Parameter Settings Activity Pulse Rate BRPM RR-Intervals Spo2 Sleep Temperature Emography NIBP AFib Continuous Disabled o Vital Parameters, Frequency, Raw Data can be set for each study on the Research Portal Raw Data ACC xyz PPGG PPG G/R/lr Autonomy Estimated battery life: 6 days

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