E220 / E220x (E-Series) High Performance Multi-Sample Preparation System High value samples demand controlled preparation… prior to committing to high cost analysis Covaris E-Series Choice of Two Models E220, 100 watts average power E220x, 250 watts average power Multi-Sample Preparation in tubes, strips or microplates • 1-96 Sample Capacity • High Recovery • High Reproducibility • Broad Applications - Disruption- Extraction- Dissolution • Automation Ready • Proven Technology Superior Technology - Isothermal processing - Non-contact, closed vessel - Focused Acoustic Energy provides controlled sample preparation across a wide range of applications - Fine acoustic treatment resolution available with SonoLab 7 control software - Easily replicate E210 acoustic methods with existing consumables and holders - Standard applications and custom programming capable he Covaris® E220 / E220x high-performance focused ultra-sonicators represent the continuing evolution of the E-Series. E220 instruments deliver industry leading sample processing capability directly to the benchtop in a scalable, multi-sample for mat. The new E-Series ultrasonicator is a workstation-based instrument capable of extremely rapid and complete homogenization, tissue disruption and sample extraction. As part of Covaris family of instruments, the E220 (and E220x) instruments provide multi-sample preparation with scalable acoustic energy, capable of processing a wide range of sample types and volumes. Both instrument versions process from 1 to 96 samples in a single batch. They can be operated in stand-alone mode or can be easily integrated as part of an automated laboratory system. In either configuration, the E-Series provides world-class AFA® sample preparation technology to our customers.. Adaptive Focused Acoustics® (AFA®) Our highly efficient and reproducible up-front sample preparation, utilizing the proprietary Covaris Adaptive Focused Acoustic (AFA) technology, eliminates operator induced variation, improves recoveries, increases efficiency, and provides standardized results. The AFA process works by transmitting focused acoustic energy wave packets from a dish-shaped transducer to the sample. The acoustic energy waves converge on the target sample in a small-localized area. When operated at low intensity levels, the computer controlled and focused waves, create a gentle mixing environment, suitable for accelerating any diffusion-dependent applications, such as compound dissolution, mass action binding events, and enzyme digestion. When operated at higher intensity levels, the instrument can create a tunable shock wave environment with subsequent shear jet forces which has been demonstrated to be ideal for tissue disruption and DNA fragmentation applications. Please visit Covaris website: www.covarisinc.com for more details on Covaris AFA technology. Isothermal processing No heat damage, higher recovery Non-contact, in closed vessel No cross contamination, no clean-up, no aerosol Precisely controlled and adjustable energy delivery Standardized processes, highly reproducible Automation ready Integrates into customers’ sample processing work flow Multi-sample capability Higher productivity, less operator intervention Broad sample volume range One instrument for multiple applications Broad Range of Applications In life science and pharmaceutical research, the following are some of the areas E-series are used: Contact Information • Compound formulation • Chromatin fragmentation • High-throughput chemistry • Tissue disruption and homogenization • Cell spore and organelle Lysis • Sample extraction for metabolic and proteomic profiling Covaris, Inc. 14 Gill Street, Unit H Woburn, Massachusetts 01801-1721 USA • Nanoparticle formation - micronization • ADME/Tox extractions

Covaris the pre-diagnostic advantage Instrument Models Covaris E220 is used in most applications. Additional E-Series™ models are available and may be recommended for certain specialized projects. Please contact Covaris for further details. Covaris E-Series systems can be operated in stand-alone mode or may be integrated with a liquid handler or as a module on an automated platform. Please contact Covaris for more details. E-Series Consumables Covaris provides a wide variety of tubes and vials specifically designed to meet your DNA fragmentation requirements. Covaris microTUBE™ and miniTUBE™...