S-Series
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Cowans'S220/S220x/S220R Focused-ultrasonicatorHigh-value Samples Demand Controlled Preparation Prior to Committing to High Cost Analysis The Covaris S220, S220x (high-power), and S220R (robotic-capable) high-performance Focused-ultrasonicators represent the continuing evolution of the S-series. S220 instruments deliver industry leading sample processing capability directly to the benchtop. The S-series is a workstation-based instrument capable of extremely rapid and complete homogenization, tissue disruption, and sample extraction. As part of the Covaris family of instruments, S220 Focused-ultrasonicators provide single-tube sample preparation with scalable acoustic energy, capable of processing a wide range of sample types and volumes. All instrument versions can be operated in stand-alone mode or can be easily integrated as part of an automated laboratory system. In any configuration, the S220 instruments provide world-class Adaptive Focused Acoustics® (AFA®) sample preparation technology to our customers. Non-contact, in closed vessel No cross contamination, no clean-up, and no aerosol Precisely controlled and adjustable energy delivery Standardized processes, highly reproducible Automation ready Integrates into customers' sample processing workflow Broad sample volume range One instrument for multiple applications Supported Applications: • Tissue disruption and homogenization • Extraction of metabolic and proteomic profiling • DNA fragmentation • RNA extraction • Nanoparticle formation - micronization • Chromatin fragmentation • Cell, spore, and organelle lysis • Compound dissolution & formulation • ADME/Tox extractions Adaptive Focused Acoustics (AFA) Our highly efficient and reproducible up-front sample preparation, utilizing the proprietary Covaris Adaptive Focused Acoustic (AFA) technology, eliminates operator induced variation, improves recoveries, increases efficiency, and provides standardized results. The AFA process works by transmitting focused acoustic energy wave packets from a dish-shaped transducer to the sample. The acoustic energy waves converge on the target sample in a small-localized area. When operated at low intensity levels, the computer controlled focused waves create a gentle mixing environment, suitable for accelerating any diffusion-dependent applications, such as compound dissolution, mass action binding events, and enzyme digestion. When operated at higher intensity levels, the instrument can create a tunable shock wave environment with subsequent shear jet forces which has been demonstrated to be ideal for tissue disruption and DNA fragmentation applications.

Sample Preparation using the S-series Product Specifications The S-series effectively enables a broad range of sample preparation applications from mixing and dissolution through Treatment Power 100 Watts Average Power (S220) Treatment System Bench-top; high intensity acoustic transducer, temperature monitoring device, circulation pump, water bath with safety enclosure 20 cm (width), 53 cm (depth), and 33 cm (height) AFA-energetics® Delivery Mode Power Requirements Regulatory Labeling CE, ETL Mark (for Product Safety), WEEE Operating System Microsoft Windows 7 or 10 with SonoLab 7 Operating...