Carpediem™
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SMALL PATIENTS. SMALL SOLUTIONS. BIG RESULTS. Carpediem™ cardio-renal pediatric dialysis emergency machine

IMPROVED CLINICAL OUTCOMES FOR YOUR SMALLEST PATIENTS The Carpediem™ System Neonate survival rate upon discontinuation of treatment.1* Acute kidney disease in neonates is common Of acute kidney injuries (AKI) are caused by sepsis.3 Mortality rates among neonates with AKI.4 AKI mortality rate among neonates supported with ECMO.3

INNOVATIONS IN PEDIATRIC CRRT For the first time, pediatric patients with acute kidney injury (AKI) and fluid overload (FO) can be treated with a dialysis system designed specifically for them.5 The first of its kind, the Carpediem™ system provides CRRT treatment for pediatric patients by: ∙ Reducing damage to blood vessel access location, while providing necessary and adequate diffusive clearances6 ∙ Enabling CVVH, CVVHD, and SCUF treatments. Pediatric patients suffer high morbidity and mortality rates from AKI and FO, when treated with retrofitted CRRT machines designed for adult...

THE RIGHT THERAPY FOR THE RIGHT PATIENT Designed on a miniaturized platform, the Carpediem™ system delivers continuous renal replacement therapy (CRRT) for pediatric patients weighing 2.5–10 kgs.7 THREE-ROLLERS PERISTALTIC PUMPS PEDIATRIC ACCESS Miniaturized pumps support reduced priming volume and pressure shock.6,8 Small catheter use reduces risk of potential damage to small pediatric vessels.6 Low priming volume mitigates risks associated with blood/ albumin priming.6 Monitors fluid output with a +/- 30 g range over 24 hours. System scales have sensitivity of +/- 1

HEMODYNAMIC ADVANTAGE Blood pump flow rate7: 2–50 mL/min Increments: 1 mL/min Infusion/dialysis pump flow rate7: Up to 10 mL/min (Depending on selected modality) Effluent pump flow rate7: Up to 15 mL/min (Depending on selected modality) Peristaltic pumps5,6,8,9 with cradle movements, instead of rotors, support small circuit lines. Carpediem™ System components are designed to: ∙ Reduce priming volume ∙ Reduce circuit pressure peaks ∙ Minimize blood hemolysis and enable the use of smaller catheter

REINVENTED Clinical decisions can now be determined without the increased risks and complexities which have traditionally plagued pCRRT treatments. For the first time, there’s no need to adapt adult machines.9 DEDICATED CRRT can be a rigorous process for small patients. The Carpediem™ system is better suited to clinically address AKI and FO for these fragile patients.5 FOCUSED The simple design of the Carpediem™ system enables staff to focus on what is important. LIFE SAVING Clinical data from the Carpediem™ EU Registry demonstrates a 97% survival rate (upon discontinuation of treatmen

PURPOSEFUL DESIGN TO GIVE EVERY BABY A CHANCE

ORDER INFORMATION CAPITAL CFN CODE CARPEDIEM™ device BL 250 HEMOFILTRATION/ HEMODIALYSIS KIT 015 FOR CARPEDIEM™ BL 250 HEMOFILTRATION/ HEMODIALYSIS KIT 025 FOR CARPEDIEM™ Pre-assembled bloodset included in the Complete kit model 015 BL 250 PREASSEMBLED DEVICE FOR HEMOFILTRATION/ HEMODIALYSIS 015 FOR CARPEDIEM™ Pre-assembled bloodset included in the Complete kit model 025 BL 250 PREASSEMBLED DEVICE FOR HEMOFILTRATION/ HEMODIALYSIS 025 FOR CARPEDIEM™ 10 ml (12 ml) HENKEJECT™* Luer Lock

References * 53% Carpediem™ system patients survived to ICU discharge. Mortality after pCRRT discontinuation due to critical illness with underlying pathologies — many not amenable to treatment. Refer to the operator’s manual for details. 1. Based on internal report CARPEDIEM System DEN180055. CARPEDIEM System De Novo Application Clinical Data Section. 2020. 2. Sutherland S, et al. AKI in Hospitalized Children Comparing the pRIFLE, AKIN, and KDIGO Definitions. CJASN. 2015; 10(4)554-61. 3. Selewski D., Charlton J., Jetton J., et al. Neonatal acute kidney injury. Pediatrics. 2015; 136(2):...