COWELL® BMP Osteoinductive Bone Graft rhBMP-2 + BCP

Osteoinductive Bone Graft 4. Mechanism of Action of COWELL BMP A. Migration of Cells with lamellipodia • COWELL® BMP is bone graft material based on the E.rhBMP-2 (E.Coli derived Recombinant Human Bone Morphogenetic Protein type 2), developed for the first time in the world. COWELL® BMP is supported with 10 years of clinical data and over 40 studies. extracellalar space stationary cell • BCP as a carrier allows maintenance of space. GTP actin filaments microtubule • Primary closure for soft tissue regeneration is not required. • Regenerates adherent gingiva. • Simplifies challenging bone grafting...

COWELL® BMP Plus (Two vials) COWELL® BMP (One vial) BMP Powder BMP Powder + BMP Coated BCP Particle • Dose and particle size of the COWELL® BMP Plus. • Dose and particle size of the COWELL® BMP Product Code Particle Dose Particle Size Product Code Particle Dose Particle Size Product Code Particle Size Particle Dose Particle Size Particle Size Particle Dose Product Code Particle Size Product Code Product Code Particle Size Product Code Particle Size Particle Dose ※ A vial of 0.1g can be used for less than one extraction socket, while 0.25g/0.5g can be used for maxillary sinus or for the wide bone...

6. User Guide COWELL® BMP INNO GF Kit (Two vials + Saline Solution + Syringe) Saline Solution & Syringe • Dose and particle size of the INNO GF Kit. a. Transfer BCP graft material (Vial I). b. Inject distilled water into vial II with lyophilized rhBMP-2 power in it and mix with the powder. c. Mix BMP solution with BCP or plus autogenic / allograft and apply into the recipient site. d. Cover the defect area using a barrier membrane or suture natural soft tissue without membrane. Product Code Particle Dose Particle Size Product Code Particle Dose Particle Size Product Code Particle Dose Particle...

7. Study Result on COWELL® BMP In Vivo Study Control group 4 weeks after surgery 8 weeks after surgery a. Inject distilled water into vial II with lyophilized rhBMP-2 power in it and mix with the powder. b. Aspirate the mixture using a syringe. Jung-Bo Huh, et al., Alveolar ridge augmentation using anodized implants coated with Escherichia coli-derived recombinant human bone morphogenetic protein 2 (Beagle dog). - Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011. Histologic Findings : Tissue specimen collected approximately four months after the maxillary sinus grafting (human) • New bone...

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