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COWELL® BMP

COWELL® BMP

Product catalog summary

Overview of COWELL® BMP:
COWELL® BMP is an osteoinductive bone graft material that utilizes E. coli-derived Recombinant Human Bone Morphogenetic Protein type 2 (rhBMP-2) combined with Biphasic Calcium Phosphate (BCP) as a carrier. It is designed to facilitate bone regeneration and is supported by a decade of clinical data and over 40 studies. The product simplifies bone grafting and soft tissue regeneration, acting directly on stem cells to induce bone regeneration without infection.

Key Features:

Contains 1mg of bone morphogenic protein per 1g of particle.
Does not require primary closure for soft tissue regeneration.
Regenerates adherent gingiva and simplifies challenging grafting procedures.

Applications:

Orthopedics: Used for fractures (tibia, radius, ulna), spine fusion, bone lengthening, osteoporosis-related fractures, bone defects, and bone fusion.
Dentistry: Addresses severely resorbed alveolar ridges, tooth extraction sockets, alveolar bone loss, maxillary sinus bone loss, and maxillofacial reconstruction.
Dermatology: Aids in damaged skin regeneration and treatment of diabetic ulcers.

Mechanism of Action:
BMP-2 adheres to stem cell membranes, inducing gene expression and migration to the recipient site. It synthesizes and secretes endogenous growth factors, promoting osteoblast and fibroblast proliferation, and tissue regeneration in osseous and gingival areas.

Product Variants and Dosage:

Available in various particle sizes (0.41~1.0mm) and BMP doses (0.1mg to 2mg).
Product codes and specific dosages are provided for different applications.

User Guide:

Three methods for application, involving mixing rhBMP-2 with distilled water and applying it to the recipient site.
Instructions for using barrier membranes or suturing natural soft tissue.

Clinical Data and Study Results:
Studies conducted at major hospitals in Korea show new bone formation around graft material without inflammatory reactions. Clinical trials demonstrate efficacy and safety in alveolar ridge augmentation and extraction socket applications.

Contact Information:
Details for Cowellmedi Co., Ltd, including addresses and contact numbers for their offices in Korea and the USA.

Catalog excerpts

COWELL® BMP Osteoinductive Bone Graft rhBMP-2 + BCP

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Osteoinductive Bone Graft 4. Mechanism of Action of COWELL BMP A. Migration of Cells with lamellipodia • COWELL® BMP is bone graft material based on the E.rhBMP-2 (E.Coli derived Recombinant Human Bone Morphogenetic Protein type 2), developed for the first time in the world. COWELL® BMP is supported with 10 years of clinical data and over 40 studies. extracellalar space stationary cell • BCP as a carrier allows maintenance of space. GTP actin filaments microtubule • Primary closure for soft tissue regeneration is not required. • Regenerates adherent gingiva. • Simplifies challenging bone grafting...

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COWELL® BMP Plus (Two vials) COWELL® BMP (One vial) BMP Powder BMP Powder + BMP Coated BCP Particle • Dose and particle size of the COWELL® BMP Plus. • Dose and particle size of the COWELL® BMP Product Code Particle Dose Particle Size Product Code Particle Dose Particle Size Product Code Particle Size Particle Dose Particle Size Particle Size Particle Dose Product Code Particle Size Product Code Product Code Particle Size Product Code Particle Size Particle Dose ※ A vial of 0.1g can be used for less than one extraction socket, while 0.25g/0.5g can be used for maxillary sinus or for the wide bone...

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6. User Guide COWELL® BMP INNO GF Kit (Two vials + Saline Solution + Syringe) Saline Solution & Syringe • Dose and particle size of the INNO GF Kit. a. Transfer BCP graft material (Vial I). b. Inject distilled water into vial II with lyophilized rhBMP-2 power in it and mix with the powder. c. Mix BMP solution with BCP or plus autogenic / allograft and apply into the recipient site. d. Cover the defect area using a barrier membrane or suture natural soft tissue without membrane. Product Code Particle Dose Particle Size Product Code Particle Dose Particle Size Product Code Particle Dose Particle...

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7. Study Result on COWELL® BMP In Vivo Study Control group 4 weeks after surgery 8 weeks after surgery a. Inject distilled water into vial II with lyophilized rhBMP-2 power in it and mix with the powder. b. Aspirate the mixture using a syringe. Jung-Bo Huh, et al., Alveolar ridge augmentation using anodized implants coated with Escherichia coli-derived recombinant human bone morphogenetic protein 2 (Beagle dog). - Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011. Histologic Findings : Tissue specimen collected approximately four months after the maxillary sinus grafting (human) • New bone...

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Cowellmedi Co.,Ltd Floor 6, Blue Fin Tower, 42, Seochojungang-ro,Seocho-gu, Seoul, Korea Tel. +82-2-3453-5085 Fax. +82-2-3453-5086 E-mail. [email protected] Cowellmedi USA INC 218 Trianon LN Villanova PA 19085-1442 USA Tel. 1-623-939-1344 Fax. 1-623-939-1472 Cowell R&D Institute 48, Hakgam-daero 221beon-gil, Sasang-gu, Busan, 46986, Korea Tel. +82-51-314-2028 Fax. +82-51-314-2026

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All Cowellmedi catalogs and technical brochures

*Prices are pre-tax. They exclude delivery charges and customs duties and do not include additional charges for installation or activation options. Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates.

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