Surgical Adhesive When it comes to versatility, BioGlue has no equal: Valve replacement For use in cardiac repair, aortic aneurysm repair and • Cardiac repair examples: Aortic valve replacement, Bentall procedures, aortic • Aortic aneurysm repair examples: Abdominal aneurysm, ascending/transverse arch/descending • Peripheral vascular repair examples: Carotid endarterectomy, aorto-femoral bypass, AV access. Aneurysm repair The only FDA approved product to seal anastomoses and to reinforce and adhere tissues. Over a decade of safe and effective use in complex cardiac and vascular repair2. • BioGlue is available in 3 volumes — • Choosing the correct volume allows you to select the amount you need, reducing waste • Various delivery tips are available • Provides options for delivering BioGlue to ensure precise application directly to the target site. Life Restoring Technologies '

Surgical Adhesive BioGlue's versatility provides additional benefits: • BioGlue is the Ideal Sealant providing • BioGlue may provide a reduced need to stock additional value to the cardiac and vascular OR products as BioGlue can provide strength and reinforcement in addition to post-op hemostasis. Steps for successful application of BioGlue: DRY target site DE-AIR the syringe PRIME the applicator tip APPLY BioGlue in thin, even layers ALLOW two minutes for full strength i Summary of Safety and Effectiveness, CryoLife. BioGlue® Surgical Adhesive. 2 CryoLife, Inc. Data on file. BioGlue® Surgical...