Featuring an early cannulation graft option* More Graft Options** • GORE® ACUSEAL • FLIXENE® Standard Wall *See inside and Instructions for Use (IFU) for more details. **Graft is not included with the Adapter. See IFU for more details on the ePTFE grafts that have been tested and are permitted for use with the Adapter. Life Restoring Technologies

HeRO Graft HeRO (Hemodialysis Reliable Outflow) Graft is the ONLY fully subcutaneous AV access solution clinically proven to maintain long-term access for hemodialysis patients with central venous stenosis. HeRO Graft Adapter connects a 6mm ID ePTFE vascular graftu (not included) and the Venous Outflow Component (VOC, not included). The Adapter has a tapered ID (6mm to 5mm) to provide a smooth transition from the graft to the VOC. Treatment Algorithm Failing AVF or AVG due to central venous stenosis Catheter-dependent patients Key Benefits • Superior Dialysis Adequacy: 1.7 Kt/V, a 16% to 32%...

Adapter Assembly Overview 1. Select a new graft (not included) from Table 1. General Warning: The Adapter should NOT be connected to any graft other than a new graft listed in Table 1. Table 1: US Marketed 6mm ID Vascular Grafts (Tested with Adapter) Trade Name Catalogue Number FLIXENE Atrium Medical 10cm SW 25053 5 Standard Wall Corporation 30cm 25142 50cm 25052 SW = Standard Wall 2. Insert Graft Expander into graft. Advance graft up to shoulder as much as possible and leave in place. 3. Ensure clamshells are open and centered around the Adapter base. ATTENTION: The clamshells CANNOT be opened...

Identifying a HeRO Graft Candidate • Is the patient currently catheter dependent or approaching catheter dependency? • Does the patient have a record of central venous stenosis? • Does the patient have swollen arms and/or distended collateral veins? • Is the measured Kt/V less than 1.4? • Has the flow rate dropped >20%? If YES n is checked for any box above, consider referring patient for a central bilateral venogram for assessment of central venous stenosis. Cost Benefits* • 3% average savings per year with the HeRO 2 Graft compared with catheters7 • Cost savings of over $3,100 (per patient/year)...