Osseolive® Dental Bone Graft When time matters, it's time for Osseolive. This unique new osteobiologic graft is designed for optimal bone grafting: it works with the body’s natural healing response to stimulate physiologic bone regeneration—without the problems associated with autograft or potential safety risks of allograft. Osseolive Dental is a new class of biomaterials made from bioactive calcium-potassium-sodiumphosphate, a modified and advanced form of tricalcium phosphate. Clinical evaluations have shown excellent bone remodeling with favorable outcomes in implantology and sinus lifts among other indications. photo courtesy: Dr. Robert Miller Implant placement T = 2 months Osseolive Dental is an osteobiologic that provides rapid resorption and remodeling, as demonstrated in this pre-clinical sheep scapula model. 1 Fig. 1 Fig. 1. Osseolive particle and particle fragment at 2 weeks showing excellent bone formation at Fig. 2. Critical-size defect 1 month after implantation of Osseolive. Extensive woven bone their surface (white arrows). In addition, strong osteocalcin expression of the mineralized bone matrix is present (short yellow arrows). Also beginning particle degradation is visible with new bone formation in these areas (black arrows). The considerable extent of new bone formation after two weeks demonstrates the excellent bioactivity of this material as well as its enhanced stimulatory effect on bone formation. formation has occurred filling the majority of the defect. Osseolive particles exhibit excellent bone-particle contact (white arrows). In addition, strong osteocalcin expression of the mineralized bone matrix is present (short yellow arrows), indicating that matrix mineralization is actively progressing in these area

Results Count2 In a thirty-eight patient sinus lift study, Osseolive "showed excellent bone formation in the sinus floor and that the bone graft had been mostly replaced by newly formed bone at six months. Excellent formation of cancellous bone in the sinus floor with few residual highly degraded Ossseolive particle fragments embedded in the newly formed bone." (d-g) histomicrographs of deacrylated sawed section stained immunohistochemically for osteocalcin (yellow arrows - residual ceramic particle fragments embedded in newly formed bone, green arrows - osteogenic mes-enchym with strong osteocalcin...