Single Chromosome Detection of aneuploidy in chromosomes 13, 18, 21, X and Y • Down syndrome Trisomy 21 - single tube test - 10 markers • Edward syndrome, Trisomy 18 - single tube test - 9 markers • Patau syndrome, Trisomy 13 - single tube test - 9 markers • Used in prenatal testing • Can be used as stand alone tests • Can be used for verification of results obtained with other tests, e.g. NIPT • Superior number of markers for each separate chromosome • Single tube test with markers for one chromosome • Optimised performance • High flexibility for users • Taq polymerase included, ready to use • Detection of maternal contamination eliminates the risk of misdiagnosis • Results are achieved within 6 hours enabling a "time to reply" of less than 24 hours. • The ChromoQuant® kits are validated for all ABI Capillary Electrophoresis sequencers Optima Single Chromosome kits holds many unique genetic markers in separate tubes. This large number of markers means the ChromoQuant® Optima kit will analyse 99,9% of all samples with an informative result. The Optima kits can be used in combination or as stand alone tests for fast diagnosis of aneuploidy. The kits can be used in combination with other ChromoQuant tests or for verification of results obtained with other tests e.g. NIPT screening. Optima XY ChromoQuant Single chromosome tests for Chr. 13, 18 and 21 can be combined with ChromoQuant Optima XY for diagnosis of aneuploidy in the sex chromosomes. GeneMarker and GeneMapper templates for easy interpretation and reporting are available as downloads.

Product specification CyberGene AB Banvaktsvagen 22 SE-171 48 Solna Sweden Sales support: [email protected] Technical support: [email protected] ChromoQuant® has been thoroughly validated. ChromoQuant® was clinically introduced in early 2004 and is used world wide. ChromoQuant® is CE marked in accordance with the IVD Directive 98/79/EC and produced by CyberGene AB under quality system ISO 13485. CyberGene AB is a Swedish company, active in the MedTech field by developing, manufacturing and selling In Vitro diagnostic products. ChromoQuant is a registered trademark of CyberGene AB.