Regeneration Bone Grafting & Soft Tissue Management Regeneration Bone Grafting & Soft Tissue Management

Bone Graft Material the Dentium graft materials 16

Regeneration Bone Grafting & Soft Tissue Management Bone Graft Material

Regeneration Bone Grafting & Soft Tissue Management OSTEON™ Il Collagen Application of OSTEON™ II Collagen • • • • • Simple grafting (volume up) Ridge augmentation Extraction site & osteotomy Cystic cavities Periodontal defect Characteristics of OSTEON™ II Collagen • • • • • Bone void filler composed of synthetic bonegraft(OSTEON™ II) and natural type I collagen Moldable to various defect shape after being wet Easy handling, thus shortened operation time OSTEON™ II is highly resorbable due to higher β-TCP content (HA:β-TCP=30:70) Collagen is absorbed over several weeks after helping the initial...

Regeneration Bone Grafting & Soft Tissue Management OSTEON™ Collagen Application of OSTEON™ Collagen • • • • • Ridge augmentation Extraction site & osteotomy Cystic cavities Sinus lift Periodontal defect Description OSTEONTM Collagen is a bone void filler composed of synthetic bone(OSTEON™), and natural type I collagen. Characteristics of OSTEON™ Collagen • • • • • • Collagen coating enables easy handling, and thus shortened operation time Moldable to various defect shape after being wet Collagen dissolves after helping the initial handling Excellent new bone formation and space maintenance Hemostatic...

Regeneration Bone Grafting & Soft Tissue Management OSTEON™ Il Application of OSTEON™ II • • • • • Ridge augmentation Extraction site & osteotomy Cystic cavities Sinus lift Periodontal defect Composition of OSTEON™ II Osteoconductive biphasic calcium phosphate with higher β-TCP Highly resorbable due to higher β-TCP content Easy manipulation Excellent wettability Osteoconductive synthetic bonegraft Pore size : 250 Porosity : 70% Microsturcure

Regeneration Bone Grafting & Soft Tissue Management 7 Cell Adhesion Test In Vitro Dissolution Test Osteoblasts attached & spreaded well Animal Test 12-weeks follow up in rabbit calvaria model

Regeneration Bone Grafting & Soft Tissue Management OSTEON™ Application of OSTEON™ • • • • • Ridge augmentation Extraction site Cystic cavities Sinus lift Periodontal defect Composition of OSTEON™ 100% Synthetic bone graft : HA scaffold coated with β-TCP Specification of OSTEON™ • 100% synthetic bone graft • Interconnected porous structure similar to that of human cancellous bone • Osteoconductive material as a bone growth scaffold Human bone Cell Adhesion Test Human ostelblast cell OSTEON™ Osteoblast cell was well attached and spreaded on OSTEON™ surface.

Regeneration Bone Grafting & Soft Tissue Management Human Histology 6.5 months after sinus graft surgery New bone OSTEON™ area = 1.24mm2 (17.1%) New bone area = 1.63mm2 (22.7%) 10 months after sinus graft surgery OSTEON™ OSTEON™ area = 3.04mm2 (35.5%) New bone area = 2.38mm2 (27.7%) 21 months after sinus graft surgery OSTEON™ OSTEON™ area = 6.30mm2 (40.4%) New bone area = 5.12mm2 (33.0%) Products Type OSTEON™ Sinus (Syringe type) OSTEON™ Lifting (Syringe type) OSTEON™ (Vial type)

10 Regeneration Bone Grafting & Soft Tissue Management Syringe Size Product OSTEON™ Sinus OSTEON™II Sinus OSTEON™ Lifting OSTEON™II Lifting Syringe outer diameter Syringe inner diameter Application of OSTEON™ Slightly retract the plunger and gently tap to loosen particles. Gently push plunger back into place. Place syringe into a sterile dappen dish and retract plunger to draw liquid into the syringe. To optimize delivery, OSTEON™ should be wetted and loosened sufficiently. Expel excess liquid by applying very gentle pressure on the plunger. When sufficiently hydrated, OSTEON™ will expel with...

Regeneration Bone Grafting & Soft Tissue Management 11

12 Regeneration Bone Grafting & Soft Tissue Management Collagen Membrane Application of Collagen Membrane Biodegradable barrier membrane for guided bone / tissue regeneration • • • • Periodontal / infrabony defects Ridge augmentation Extraction sites (implant preparation / placement) Sinus lift Characteristics of Collagen Membrane • • • • Easy manipulation Dual-sided usage Barrier function lasting for 6 months Highly pure type I collagen derived from bovine tendon ) with multiple layers for easy manipulation and sufficient mechanical strength in surgery. • Resorption period of 6 months to provide...

Regeneration Bone Grafting & Soft Tissue Management 13 Animal Test Rabbit calvaria model, 6-12 weeks In Vitro Dissolution Test

14 Regeneration Bone Grafting & Soft Tissue Management HA Collagen Membrane Application of HA Collagen Membrane • • • • • • Resorbable collagen membrane containing hydroxyapatite (HA) particles Periodontal / Infrabony defects Ridge augmentation Extraction sites Guided Bone Regeneration(GBR) procedure Sinus lift Characteristics of HA Collagen Membrane • • • • Resorbable barrier membrane Osteoconductive due to HA particles New bone formation through the membrane Highly pure type I collagen derived from bovine tendon Cell Adhesion Test Animal Test Rabbit calvaria model, 12 weeks Products Type HA...

Regeneration Bone Grafting & Soft Tissue Management 15 Clinical application of the Dentium graft materials

16 Regeneration Bone Grafting & Soft Tissue Management Ridge augmentation (Defect) OSTEON™ ll + Collagen Membrane Fixture Implantation Application of graft material OSTEON™ ll Barrier membrane application Collagen Membrane Healing Abutment Connection Dual Abutment Connection Final prosthesis Final prosthesis New bone formation