Regeneration Bone Grafting & Soft Tissue Management

Histological result of OSTEON™ III In vivo test 8 weeks

Regeneration Products Information Table of Contents Bone Graft Materials OSTEON™ III 6 Membrane Materials Collagen Graft 12

Regeneration : Bone Grafting & Soft Tissue Management

Regeneration : Bone Grafting & Soft Tissue Management Bone Graft Materials

Regeneration : Bone Grafting & Soft Tissue Management Ridge augmentation Extraction site & osteotomy Sinus lift Periodontal defect OSTEON™ III = HA 60% + β-TCP 40% OSTEON™ III is a biphasic calcium phosphate composed of 60% HA (Hydroxyapatite) and 40% β-TCP (Beta-tricalcium phosphate) Easy manipulation Excellent wettability Osteoconductive synthetic bone graft Porosity : 80% Animal Test Rabbit calvaria model, 4-8 weeks Bone Graft Bone Graft Newly formed bone Newly formed bone

Regeneration : Bone Grafting & Soft Tissue Management Ridge augmentation Extraction site & osteotomy Cystic cavities Sinus lift Periodontal defect OSTEON™ II = HA 30% + β-TCP 70% Osteoconductive biphasic calcium phosphate with higher β-TCP Highly resorbable due to higher β-TCP content Easy manipulation Excellent wettability Osteoconductive synthetic bone graft Pore size : 250㎛ Porosity : 70% Cell Adhesion Test In Vitro Dissolution Test Animal Test 12 weeks follow up in rabbit calv

Regeneration : Bone Grafting & Soft Tissue Management Simple grafting (volume up) Ridge augmentation Extraction socket grafting Cystic cavities Periodontal defect Characteristics of OSTEON™ 3 Collagen Bone void filler composed of synthetic bone graft (OSTEON™ III) and natural Type I Collagen Moldable to various defect shapes after being wet Easy handing, thus allowing reduced chair time OSTEON™ III has 80% porosity as a result of highly interconnected macro and micro-pores beneficial for new bone formation Collagen is absorbed within several weeks after helping the initial shaping Relative weight...

Regeneration : Bone Grafting & Soft Tissue Management Simple grafting (volume up) Ridge augmentation Extraction socket grafting Cystic cavities Periodontal defect Characteristics of OSTEON™ II Collagen • • • • • Bone void filler composed of synthetic bone graft (OSTEON™ II) and natural type I collagen Moldable to various defect shape after being wet Easy handling, thus shortened operation time OSTEON™ II is highly resorbable due to higher β-TCP content (HA:β-TCP=30:70) Collagen is absorbed within several weeks after helping the initial shaping Animal Test Newly formed bone Animals : New zealand...

10 Regeneration : Bone Grafting & Soft Tissue Management

Regeneration : Bone Grafting & Soft Tissue Management 11 Membrane Materials

12 Regeneration : Bone Grafting & Soft Tissue Management Graft Applications • Gyngival augmentation • Alveolar ridge reconstruction • Root coverage Characteristics of Collagen Graft • Double layered : Dense layer + Porous layer • Faster soft tissue healing by promoted epithelization • Function for hemotasis and wound site protection Relative weight(wt%) Tensile strength[MPa] Microstructure Porous Layer x50

Regeneration : Bone Grafting & Soft Tissue Management 13 Membrane-P Applications • • • • Periodontal defects Ridge augmentation Sinus Lift GBR procedure Soft type resorbable barrier membrane with excellent manipulation Barrier function lasting for 4 months Highly pure type I collagen Both sides usable Relative weight(wt%) suture strength[g] GENOSS Collagen Membrane Collagen Membrane-P B < Collagen Membrane-P < A ≒ GENOSS Collagen Membrane Cross section

14 Regeneration : Bone Grafting & Soft Tissue Management Periodontal / infrabony defects Ridge augmentation Extraction sites (implant preparation / placement) Sinus lift GBR procedure Characteristics of Collagen Membrane • • • • Easy manipulation Both sides usable Barrier function lasting for 6 months Highly pure type I collagen • Thinner membrane (300㎛) with multiple layers for easy manipulation and sufficient mechanical strength in surgery • Resorption period of 6 months to provide enough time for stabilizing graft materials and supporting bone growth • Multiple-layered structure enables more...

Regeneration : Bone Grafting & Soft Tissue Management 15 Periodontal / Infrabony defects Ridge augmentation Extraction sites GBR procedure Sinus lift Characteristics of HA Collagen Membrane • • • • Resorbable barrier membrane Osteoconductive due to HA particles New bone formation through the membrane Highly pure type I collagen Cell adhesion Animal Test Rabbit calvaria model, 1

16 Regeneration : Bone Grafting & Soft Tissue Management

Regeneration : Bone Grafting & Soft Tissue Management 17 Implantation with GBR on missing molar area Recommended treatment Dr. Dong-Wook Chang / Win Dental Clinic Flap reflection Healing 3 months, 2nd surgery Final prosthesis Recommended treatment Dr. Seung-Min Han / Seoul Ichon Dental Clinic OSTEON™ III OSTEON™ II Collagen Membrane Bone defect Collagen Membrane Healing 4 months, 2nd surgery

18 Regeneration : Bone Grafting & Soft Tissue Management Socket preservation Recommended treatment OSTEON™ II Collagen Provisional restoration Final prosthesis Recommended treatment OSTEON™ II Collagen Provisional restoration Final prosthesis

Regeneration : Bone Grafting & Soft Tissue Management 19 Immediate implantation Recommended treatment OSTEON™ III Collagen Graft Implant Guide Extraction & Flap reflection OSTEON™ III, Collagen Graft Final prosthesis Recommended treatment OSTEON™ II Collagen Membrane Extraction & Flap reflection Autogenous bone Collagen Membrane Healing 3 months, 2nd surgery Final prosthesis Final prost

20 Regeneration : Bone Grafting & Soft Tissue Management Recommended treatment OSTEON™ II Collagen Implantation SuperLine 3610, OSTEON™ ll Collagen Healing 2 months, 2nd surgery Final prosthesis Recommended treatment OSTEON™ II Implant Guide Final prosthesis Final prost