Cholinesterase FS

Cholinesterase FS

Cholinesterase FS

Product catalog summary
Product Overview: The document describes a liquid-stable, ready-to-use reagent for measuring cholinesterase activity using the Butyrylthiocholine method, recommended by the DGKC. The reagent is linear up to 20,000 U/L and shows no interference from hemolyzed, lipemic, or icteric samples. It offers excellent precision and has an on-board/calibration stability of 8 weeks on the Hitachi 911 analyzer. The reagent is adaptable to various clinical chemistry analyzers, with validated applications available.
Kit Specifications: Multiple kit configurations are available for different analyzers, including Hitachi and Olympus systems. Each kit contains specific volumes of reagents R1 and R2, tailored for compatibility with the respective analyzers.
Chemical Reaction: Cholinesterase hydrolyzes Butyrylthiocholine to Butyric acid and Thiocholine. Thiocholine reduces yellow Potassium hexacyanoferrate(III) to colorless Potassium hexacyanoferrate(II), with the decrease in absorbance measured at 405 nm.
Clinical Use: Cholinesterase measurement is crucial for monitoring liver conditions such as acute and chronic hepatitis, liver cirrhosis, and liver tumors. It is also used for monitoring workers exposed to pesticides and in pre-operative diagnostics due to its role in inactivating muscle relaxants. Increased cholinesterase values are less clinically significant but may occur in conditions like alcoholic fatty liver, diabetes, or nephrotic syndrome.
Performance Data: The document includes performance data comparing the DGKC recommended method with competitor methods, showing high correlation coefficients (r = 0.994 and r = 0.992) and regression equations indicating strong agreement between methods.
Contact Information: DiaSys Diagnostic Systems GmbH, located in Holzheim, Germany, provides contact details for further inquiries.
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Catalog excerpts

Cholinesterase FS-1

:: CLINICAL CHEMISTRY cholinesterase fs – the liquid solution :: Liquid-stable, ready to use reagent :: Butyrylthiocholine method, recommended by DGKC :: Linearity up to 20,000 U/L :: No interferences by hemolyzed, lipemic or icteric samples :: Excellent precision :: On board/calibration stability 8 weeks (Hitachi 911) :: Adaptable on any clinical chemistry analyzer, validated applications available

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Cholinesterase FS-2

Cliiuse ecreased CHE values occur in acute and chronic hepatitis, liver cirrhosis, liver tumours and liver inhibition by intoxication. Cholinesterase is measured for monitoring workers exposed to pesticides and in pre-operative diagnostics as CHE is needed inactivation of muscle relaxants used in surgery. Increased values are of less importance and can occur in alcoholic fatty liver, diabetes or nephrotic syndrom. 2 Thiocholine + 2[Fe(CN)6] " + H2O Cholinesterase hydrolyses Butyrylthiocholine to Butyric acid and Thiocholine. Thiocholine reduces yellow Potassium hexacyanoferrate(III) to colourless...

 Open the catalog to page 2

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