Iron Metabolism

Iron Metabolism

Iron Metabolism

Product catalog summary
Iron Metabolism Diagnostics Overview
Iron is crucial for cellular functions, primarily involved in oxygen transport and storage. It is absorbed in its ferrous form (Fe2+) and oxidized to ferric iron (Fe3+) to bind with transferrin for transport. Excess iron is stored as ferritin, mainly in the liver, spleen, and bone marrow. Iron is predominantly found in hemoglobin, and its recycling occurs through phagocytosis of aging erythrocytes.

Clinical Relevance
Disorders in iron metabolism can lead to significant health issues. Hemochromatosis and liver damage are associated with increased iron levels, while anemia is linked to decreased levels. Elevated transferrin levels may indicate iron deficiency, and transferrin saturation is used to screen for hemochromatosis. Serum ferritin levels reflect tissue iron status, with low levels indicating iron deficiency anemia and high levels suggesting iron overload or chronic conditions.

Diagnostic Tests and Benefits
DiaSys offers a range of diagnostic tests for iron metabolism, including:
  • Ferritin FS: A particle-enhanced immunoturbidimetric assay with a wide measuring range and high prozone security.
  • Iron FS Ferene: A colorimetric test with high linearity and stability.
  • Transferrin FS: An immunoturbidimetric test with high linearity and prozone security.
  • UIBC FS: A colorimetric test using Ferene, with ready-to-use reagents and high linearity.
These tests offer benefits such as liquid-stable reagents, high precision, minimized interferences, and traceability to international standards.

Method Comparisons
Comparative analyses with competitor products show high correlation and reliability of DiaSys tests, ensuring accurate diagnostics.

Company Information
DiaSys Diagnostic Systems GmbH is a global leader in clinical chemistry tests, known for high-quality products made in Germany. The company adheres to ISO certifications and emphasizes sustainable processes and premium service.
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Catalog excerpts

Iron Metabolism-1

The Essentials For Reliable Iron Diagnostics • Iron • Transferrin • Ferritin • UIBC DiaSys Diagnostic Systems CHOOSING QUALITY.

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Iron Metabolism-2

Iron Metabolism Iron is an essential element in living cells and part of many metabolic pathways including transport and storage of oxygen. Iron uptake mainly occurs in its ferrous form (Fe2+). Oxidized to ferric iron (Fe3+) it is bound to the transport protein transferrin and delivered to target tissues. After endocytosis iron is incorporated into cytochromes, oxygen-binding proteins or enzymes. Excess iron is stored in a protein complex as ferritin, mainly present in liver, spleen and bone marrow. The main amount of iron is found in hemoglobin. Aging erythrocytes undergo phagocytosis resulting...

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Iron Metabolism-3

• Particle-enhanced immunoturbidimetric assay • Wide measuring range from 5 to 1000 μg / L • Superior prozone security up to 30000 μg / L • Calibration and on-board stability ≥ 25 days • Use of serum and plasma • Immunoturbidimetric test • High linearity up to 800 mg / dL • Prozone security up to 2000 mg / dL • Calibration and on-board stability 4 weeks • Use of serum and plasma Method comparison DiaSys Transferrin FS (mg/dL) DiaSys Ferritin FS (µg / L) Competitor Ferritin (µg / L) Competitor Transferrin (mg / dL) • Colorimetric test using Ferene as chelating agent • High linearity up to 1000 μg / dL...

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Iron Metabolism-4

Leading Technology in Fluid-stable Reagents from DiaSys • Global player in clinical chemistry tests with recognized R & D department • Quality products made in Germany • High quality raw materials from traceable origin • Processes and resources certified according to ISO 13485, ISO 9001, fulfilling highest internal quality standards • Sustainable processes and products preserve the environment • High performance ready-to-use reagents with minimized interferences, long shelf life, on-board stability and traceability to international references • Perfectly matched fluid-stable reagents, calibrators...

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