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Lactate FS

Product catalog summary

Clinical Relevance
When cellular oxygen levels are low or mitochondria malfunction, energy production shifts to an anaerobic mode, producing lactate as a by-product. Lactate is metabolized by the liver, maintaining normal levels. However, in conditions like shock, sepsis, and burn injuries, lactate levels rise, serving as a prognostic marker in intensive care and emergency settings. It is also used in neonatal care to monitor oxygen supply in newborns and in sports to optimize athletes' performance.

Precision
The document provides precision data for intra-assay and inter-assay measurements with three samples, showing mean values, standard deviations, and coefficients of variation. For instance, Sample 1 has an intra-assay mean of 5.60 mg/dL with a CV of 2.29% and an inter-assay mean of 7.33 mg/dL with a CV of 2.62%.

Reaction Principle
The assay measures the increase in absorbance at 340 nm, which is proportional to the lactate concentration in the sample.

Performance Highlights
The reagent is fluid-stable and ready-to-use, offering good comparability to competitor assays. It shows no interference from ascorbic acid up to 30 mg/dL, bilirubin up to 60 mg/dL, triglycerides up to 2000 mg/dL, and hemoglobin up to 1000 mg/dL. It is easily applicable to various clinical chemistry analyzers.

Catalog excerpts

Fluid-Stable. Ready-To-Use. Excellent Performance. DiaSys Diagnostic Systems CHOOSING QUALITY.

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When the cellular oxygen level is low or mitochondria are not working properly, energy production switches to a less efficient anaerobic modus. In this modus the primary by-product is lactate. Lactate is transported to the liver and metabolized there. Normally the liver breaks down lactate immediately, therefore its level stays within the normal range. In case of shock, sepsis and burn injuries lactate level increases and serves as a prognostic marker in intensive care units and emergency rooms. Furthermore lactate is determined in neonatal care units to control oxygen supply in newborn and premature...

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