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Mill Mix 20 - Pharmacy - Hard Tablet Grinding

Mill Mix 20 - Pharmacy - Hard Tablet Grinding

Mill Mix 20 - Pharmacy - Hard Tablet Grinding

Product catalog summary
Introduction
The document outlines a grinding solution using MillMix 20 and Polytron® PT 2500 E, developed for quality control (QC) of tablets in the pharmaceutical industry. The solution aims to enhance the efficiency of active pharmaceutical ingredient (API) yield and reduce processing time.

Specifications
  • MillMix 20: Utilizes a 50 ml stainless steel jar with a Ø25 mm ball, operating at 30Hz for 1 minute.
  • Polytron® PT 2500 E: Features a grinding shaft with flask capacities ranging from 100ml to 500ml, processing 1-10 tablets in 1 minute.

Efficiency and Savings
  • The new QC method increases API yield by 6-8%, achieving a 98-100% yield.
  • Processing time is reduced to 15 minutes compared to the conventional 30 minutes, saving significant time in daily operations.
  • Globally, the application could save over 1,200 tons of API annually, equating to a financial saving of $60 million.

Application and Results
  • Applicable to all types of hard tablets with a feed size of 1, 2, 5, 10, or 20 tablets, depending on requirements.
  • Feed quantity is 50% of the jar volume, with material specifications being dry and hard.
  • Customer requirements include achieving a particle size of less than 50 microns for subsequent analysis.
  • Achieved results show a 98-99.99% yield of API (ASA), demonstrating excellent efficiency in both time and API yield.

Conclusion
The report highlights the impressive efficiency of the grinding solution, providing a reference for users to optimize their tablet grinding processes.
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Catalog excerpts

Mill Mix 20 - Pharmacy - Hard Tablet Grinding-1

TABLET GRINDING SOLUTION MillMix 20, POLYTRON® PT 2500 E MAIN FEATURES: > SAVE up to 8% API > 98% - 100% yield API > SAVE 30min per tablet QC Grinding solution with MillMix20 and Polytron® PT 2500 E is developed for QC of tablets in pharmaceutical industry. Save API About 40.000 tons of Aspirin is consumed in one year worldwide. Each tablet contains about 70% API. With this application could be saved globally more than 1.200 tons API per year - this means 60 millions $. Time & Speed Stainless steel POLYTRON® PT 2500 E Grinding shaft Extremely high efficiency of yield API The new QC method increases yield of API for 6 - 8%. Save time Shorter processing time takes 15min, conventional about 30min. Imagine, how much can be done in an extra 5 hours a day! We reserve the right to alter specification details etc. without prior notice or liability! DOMEL, d.o.o., BU Laboratory Systems, Otoki 21, SI- 4228 Železniki Phone: +386 4 5117 500 , Fax: +386 4 5117 501, E-mail: [email protected] WEB: www.domel.com/products/laboratory-equipm

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Mill Mix 20 - Pharmacy - Hard Tablet Grinding-2

TABLET GRINDING SOLUTION MillMix 20, POLYTRON® PT 2500 E TEST REPORT Report No.: Date: Contact: Ref. file: TASK: Application field: All types of hard TABLET Feed size: Feed quantity: Material specification: Customer requirements: Subsequent analysis: <50 microns Sample preparation for subsequent extraction of pharmaceutical agents API or ASA SOLUTION: Configurations: Grinding with Mill Mix 20, jars 50 ml stainless steel, ball f25 mm Dispersing with POLYTHRON® PT2500, shaft f 7 (f 12 for volume bigger than 250 ml) Achieved results: Excellent result - impressive efficiency (time and API) Measurements...

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*Prices are pre-tax. They exclude delivery charges and customs duties and do not include additional charges for installation or activation options. Prices are indicative only and may vary by country, with changes to the cost of raw materials and exchange rates.