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Table of Contents Introduction to FinePointe Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 About FinePointe Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 FinePointe for Resistance and Compliance . . . . . . . . . . . . . . . . . . . . . . FinePointe for Non-Invasive Airway Mechanics . . . . . . . . . . . . . . . . . . . 8 FinePointe for Whole Body Plethysmography . . . . . . . . . . . . . . . . . . . . 10 Pulmonary Function...

Introduction to FinePointe Systems About FinePointe Systems DSI’s Buxco FinePointe* systems are a new class of research products — software and hardware — that focus on collecting data and reporting results in the fastest, easiest, and most reliable manner. Clean and Compact FinePointe systems are highly integrated, space efficient, and easy to assemble. The new hardware designs offer better control at the subject apparatus (or subject “site”). Simple, yet Powerful FinePointe systems set new standards for ease of operation. Each collection site includes a console that provides you with real time...

Introduction to FinePointe Systems FinePointe software and FinePointe hardware were made for each other. Pairing them leverages the strengths of each —easiest operation, highest throughput, and maximum efficiency overall. Easy Setup Well-placed, preconfigured hardware and color-coded cables make setup fast and easy. Easy setup and take down make these systems extremely portable. Automated Calibration Automated calibration eliminates user errors from one of the most error-prone tasks in data collection. Since FinePointe also runs system checks on the apparatus during calibration, you can be certain...

• Continuously measure lung resistance and dynamic compliance in anesthetized animals • Automated calibration • Heated bed • In-line aerosol delivery and control • Built-in FinePointe console enables control from the site • Use with intubated animals for longitudinal studies • Intelligent ventilator supports protocol-driven deep inflations, breath holds, and PEEP • Single USB connection to computer • Live display and monitoring of the signals and derived data • Multiple and simultaneous subjects capable (no limits) • Optional static compliance measurement available • Optional heart rate or blood pressure...

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FinePointe for Non-Invasive Airway Mechanics (NAM) Features • Continuously measures specific airway resistance in conscious animals • Automated calibration • Aerosol delivery and control • Allay™ chamber design significantly reduces subject loading and acclimation time • Chambers incorporate the patented Halcyon® noise-suppression design • Scalable for high throughput - easily attach 12 sites to a single computer • Each USB connection to computer supports 2 or 4 chambers • Uses Allay™ Restraint for maximum subject comfort DSI's FinePointe Series NAM sites are used to acquire specific airway resistance...

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• Subjects are conscious and unrestrained • Continuously measure respiratory rate, TV and MV • Continuously measure for index of bronchoconstriction (PenH and Pause) • Continuously measure airway irritation (TB and TP) • Use for cough analysis • Automated calibration • Aerosol delivery and control • Chambers incorporate the patented Halcyon® noise-suppression design • High throughput - easily attach and measure data from more than 12 sites simultaneously, with a single computer • Each USB connection to computer supports 2 or 4 plethysmographs • Pre-calibrated digital and Temperature and Humidity sensors •...

An example of a report in the FinePointe software including ANOVA statistics. The Whole Body Plethysmograph measures box flow, which is indirectly caused by respiratory flow of the animal inside the chamber. Respiratory volume and flow parameters estimated from box flow are typically accurate to within 30%. Real-time temperature and humidity monitoring further improves the accuracy of these parameters. Whole body plethysmography can also be used to measure Time of Pause and Time of Break—indicators of airway irritation1. These parameters indicate where in the airway irritation occurs. Outfitted...

Pulmonary Function Testing (PFT) Features • Most comprehensive assessment of the lung • Complete a series of tests in just minutes • View results immediately, use overlays to compare repeated tests • Ideal for chronic obstructive pulmonary disease (COPD) studies • Determine FRC and other lung capacities • Software reports forced expiratory volume (FEV), forced expiratory flow (FEF), and many other values • Direct measurement of pulmonary mechanics - lung resistance and dynamic compliance • Reports produce group average of P-V loops and F-V loops Available for: Mice, Rats, Guinea Pigs, and NHP. Additional...