Application Note iPRECIO Infusion Model An Innovative Infusion Solution Through our partnership with Primetech, Corp, DSI is pleased to offer the first available programmable and fully implantable infusion pump to researchers using small animal models. Researchers can now control their desired flow rates with confidence and monitor physiologic response all from one company. Receive the same high level of customer support and service that DSI has offered for more than 20 years. iPRECIO Features Programmable Programmable Infusion protocol up to 10 different steps The completed protocol is downloaded to the pump via USB and ready for implant. The maximum total Infusion Volume is 4.5 – 5.8 ml, dependent on flow rates ranging between 1µL/hr - 30µL/hr. Implantable Totally implanted in the subcutaneous space Refillable Refillable percutaneously via septum while in vivo Accurate Patented Rotary Finger Method provides highly accurate µL infusion Advantages iPRECIO is an innovative micro infusion pump that uses patented mechanical pump technology to accurately infuse fluids at the discretion of the investigator rather than the limitations of the technology. In contrast to other commercially available pumps, iPRECIO enables researchers to run chronic infusion studies while assuring subjects are receiving accurate infusion rates at pre-determined schedules. A refillable reservoir can be accessed percutaneously via a septum, enabling researchers to extend protocols and obtain desired endpoints not easily accomplished with other technologies. (Durations dependant on chosen flow rates.) Programming iPRECIO enables investigators to set infusion protocols prior to the start of the study. Start & Stop day/time, Flow rate/ mode and infusion duration/mode are all user set. iPRECIO Flow Rate Options include: Constant Flow Rate Mode: Configure one constant flow rate for infusion between 1 – 30 µl/hr Variable Flow Rate Mode Configure up to10 discrete infusion “steps” between 1 – 30 µl/hr Recovery Mode Manage your infusion start time by incorporating post surgical recovery time in your protocol. You can now time initial infusion to meet your needs! Repeat Mode Program circadian rhythm, multiple dose regimens or studies for dose response curves-only with iPRECIO Refill in Vivo! Run chronic infusion studies without the need to replace empty pumps. Port access to the pump reservoir enables researchers to continue infusions without subjecting the animal to additional surgeries or increasing study subjects. iPRECIO’s proprietary management software calculates refill windows and allows users to adjust volumes to ensure continued artic

A Complete Solution DSI transmitters are designed to collect and transmit chronic data from conscious freely moving animals. Our comprehensive physiologic monitoring platform provides flexibility and accuracy not available from any other vendor. Telemetric monitoring supports the 3R’s, by reducing animal numbers, refining study design and replacing labor intensive study methods. Adding telemetry to a chronic infusion protocol using the iPRECIO infusion pump enables researchers to run better studies and increase the likelihood of new discoveries in research areas such as: Neuroscience Cardiovascular...