Ablatherm® HIFU
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HIFU INTEGRATED IMAGING Going the extra mile for your patients Move up a gear with ultrasound technology T R E AT I N G LOCALIZED P R O S TAT E CANCER HIFU - High Intensity Focused Ultrasound www.edap-tms.com

AblathErnv Ablatherm® HIFU Going the extra mile for your patients High Intensity Focused Ultrasound Inserm Jointly developed by the French National institute tot^!*** ia Mec::ai: Psiea-ch (INSERM) ami CDAP TMS ™ma*Ma*m ► Precise and irreversible coagulation necrosis ► Preservation of surrounding tissues Right prostate lobe treatment • 3 treatment protocols (power algorithms) • First-line treatment • Repeat treatment • Salvage treatment after EBRT • Complete, partial or nerve-sparing treatment strategy ► Early feedback via rapid PSA Nadir (does not increase Gleason score) ► Does not preclude...

Take control of your new robotic assistant Real-time visualization during scanning and firing phases 3 MHz EDAP TMS treatment transducer 7.5 MHz B&K imaging transducer Computer controlled movements 3-dimensional Micro steps

Automated safety features ► Easy monitoring from ► Patented fluid for optimal ultrasound transmission ► Closed system without contamination risk ► Rectal cooling system ► Reduce prostate movements

State-of-the-art surgical robotic assistant Minimally-invasive – Radiation-free Short hospital stay (0-3 days) Spinal or general anaesthesia Quick recovery Quality of life [5] 50% 49% Range published in the literature since 2000 40 20 Quality of life Occurrence % 30 Low morbidity [3] 15% Consistent results in the litterature [1] [6] 7% [2] 2,3% 10 HIFU [a] [4] 5% 0% EBRT [b] No late onset incontinence or impotence Radical [b] Prostatectomy Incontinence 100 [a] excluding grade 1, [b] pad rate. [1] Ficarra et al, BJU Int. 2006 Dec;98(6):1193-8. [2] Chaussy and Thuroff Curr Urol Rep....

Ablatherm® HIFU Efficacy 100 80 Indications Range published in the literature since 2000 86% 86% 78% 93% 87% 88% 82% 85% 75% 83% 77% 2006 n=58 [9] 2006 n=30 [8] 2004 n=146 [7] 2003 n=175 [6] 2007 n=227 [4] Treatment for local recurrence after EBRT or radical prostatectomy 2003 n=120 [3] 20 2001 n=102 [2] First-line treatment for patients who are not suitable for surgery 2000 n=82 [1] 40 2003 n=96 [6] T1 – T2 localized prostate cancer 2003 (multicenter) n=402 [5] 60 0 Gelet, Poissonnier, Lyon Chaussy, Blana, Ficarra, Lee, Thüroff, Munich Regensburg Verona Seoul Negative biopsy rate 100%...

State-of-the-art surgical robotic assistant Quality of life [5] 50% 49% Range published in the literature since 2000 30 No late onset incontinence or impotence 20 Occurrence % 40 [3] 15% [1] [6] 7% [2] 2,3% 10 HIFU [a] 5% [4] 0% EBRT [b] Radical [b] Prostatectomy Incontinence [5] 100% [a] excluding grade 1, [b] pad rate. [1] Ficarra et al, BJU Int. 2006 Dec;98(6):1193-8. [2] Chaussy and Thuroff Curr Urol Rep. 2003;4(3):24852. [3] Zelefsky et al, Int J Radiat Oncol Biol Phys. 2002 Aug 1;53(5):11116; [4] Brabbins et al, Int J Radiat Oncol Biol Phys. 2005 Feb 1;61(2):400-8. [5] Steineck et al,...

Ablatherm® HIFU Using the latest technology break Treatment preparation Consumable setting: Ablapak® • • • • Patented fluid for optimal ultrasound transmission Closed system without contamination risk Rectal cooling system Reduces prostate movements 00:10 Safety T°c Ideal patient positioning • No potential interference of the ultrasound by gas bubbles • Continuous Ablasonic® fluid degassing 00:15 Right lateral decubitus Safety Treatment protocol choice First-line treatment Institut national de la santé et de la recherche médicale • Clinically validated power algorithms jointly developed by...

Take control of your new robotic assistant kthroughs for each treatment step Treatment start Prostate volume scanning EDAP TMS 3 MHz • B&K imaging transducer (7.5 MHz / 128 elements electronic array) • Real-time visualization • 3D volume reconstruction 00:30 B&K 7.5 MHz Safety Intraoperative treatment planning • Variable lesion height: 19 to 26 mm • Rectum is completely excluded from the treatment area with a 3 to 8 mm safety distance 00:40 The prostate is fully treated with a single pass from the anterior to the posterior part Safety Automated treatment 01:00 Accuracy ± 1mm • Automated and...

You Master Urology We Master Therapeutic Ultrasound By consistently investing in research and development and by forming partnerships with internationally-renowned medical research institutions, EDAP TMS has been able to patent innovative technologies. EDAP TMS is present in many countries via an extensive network of Subsidiaries and Distribution Partners. The Company focuses on producing a high standard of service for health care practitioners: mobile equipment, training centers and a far-reaching maintenance network. With Ablatherm® HIFU, EDAP TMS is the world leader in High Intensity...