Edwards Prima Plus Stentless Bioprosthesis The Edwards Prima Plus Stentless valve couples proven bioprosthetic valve technology with the pliability reminiscent of a homograft to form the Biograft. In addition to its unique feel, the Biograft is designed for easier implantation, valve orientation and valve trimming. These features are extremely important in the more technically demanding implantation techniques required by stentless valves. Our Edwards Prima Plus valves feature: ■ “Edwards Prima Plus valve’s softer feel facilitates implantation in comparison to other stentless valves I’ve implanted.” - Dr. Scott Goldman New Patented Edwards XenoLogiX Treatment – Significantly reduced calcification in rat and sheep implant studies.1, 2 * Low-pressure Fixation Technology – The Edwards process that has set the industry standard. – Minimizes alterations in the collagen waveform and increases leaflet compliance. Innovative Design – Bioprosthesis combined with homograft gives the flexible feel of a Biograft. – Stentless valve in its native aortic cylinder. Easier Implantation – Patented trim guide simplifies trimming for subcoronary implantation. – Dedicated cylindrical sizers reliably mirror valve dimensions. – Integrated holder may be used with the Edwards handle for convenience. *No clinical data are available which evaluate the long-term impact of the XenoLogiX treatment in patients.

Edwards Prima Plus Stentless Bioprosthesis Model 2500P Regression of Left Ventricular Mass4 Freedom From Structural Valve Deterioration (%) 3 Aortic Valve Replacement - All Patients Edwards Stentless Valve p=0.005 Edwards Prima Plus Stentless valve benefits from the company’s years of unparalleled tissue experience. Based on current clinical data out to eight years, durability results are excellent. This chart of left ventricular mass regression shows improvement from discharge to one year. Regression of hypertrophy is a more direct parameter to quantify the reduced work of the left ventricle...