ENSEAL® X1 Tissue Sealers Expect more. 1. ENSEAL® X1 Curved Jaw has a longer jaw, longer cut length and wider jaw aperture compared to LigaSure Maryland (LF1937) (p < 0.001). In benchtop testing on porcine arteries, vessels sealed with ENSEAL® X1 Curved Jaw had a 22% higher average burst pressure than vessels sealed with LigaSure™ Maryland (LF1937), (1055mmHg vs. 862mmHg, p < 0.001). (145171-200630). 2. Based on metrology data, ENSEAL® X1 Straight Jaw Tissue Sealer has a 6% (or 1.1mm) longer jaw than LigaSure™ Blunt Tip (LF1837) (p < 0.001). (093775-210608). 3. Preclinical test of distal tip bleeding (ENSEAL® vs. Impact-LF4318) in thick porcine mesentery base (p=0.001). (09344

ENSEAL® X1 Tissue Sealers offer more than LigaSure™ More secure More efficient The ENSEAL X1 Tissue Sealers are advanced bipolar devices designed for use in open or laparoscopic surgical procedures.* They have been completely redesigned to provide secure sealing with more intuitive, simplified steps-for-use. *ENSEAL X1 Large Jaw is intended for use in open surgical procedures 4. Preclinical test of distal tip bleeding (ENSEAL® X1 Large Jaw vs Impact-LF4318) in thick porcine mesentery base (p=0.001). (093443-201029). 5. ENSEAL® X1 Curved Jaw Tissue Sealer can capture, seal and transect a longer...

ENSEAL® X1 Curved Jaw Tissue Sealer More efficient Curved, tapered tip designed for fine dissection11 • Can capture more tissue per bite with a longer jaw and wider jaw aperture8 • 32% stronger distal tip grasping compared to LigaSure™ Maryland9 • 360° continuous shaft rotation to enable easy access to targeted tissue10 ENSEAL® X1 Curved Jaw can capture more tissue per bite with a longer jaw and wider jaw aperture compared to LigaSure™ Maryland 8 LigaSure™ Maryland REFERENCES: 7. ENSEAL® X1 Curved Jaw Tissue Sealer can capture, seal and transect a longer length of tissue per single activation...

ENSEAL® X1 Straight Jaw Tissue Sealer More efficient than LigaSure™ Blunt Tip12 • Can capture more tissue per bite with a longer jaw12 • Transect more tissue at a time with a 10% longer cut length13 • 360° continuous shaft rotation to enable easy access to targeted tissue14 ENSEAL® X1 Straight Jaw can capture more tissue per bite with a longer jaw compared to LigaSure™ Blunt Tip15 12. Based on metrology data, ENSEAL® X1 Straight Jaw Tissue Sealer has a 6% (or 1.1mm) longer jaw than LigaSure™ Blunt Tip (LF1837) (p < 0.001). (093775-210608). 13. Metrology report comparing ENSEAL® X1 Straight Jaw...

ENSEAL® X1 Large Jaw Tissue Sealer More secure than LigaSure Impact™16 • Enabled better sealing with less bleeding at the distal tip16 • Had 41% less lateral thermal spread17 • Has a better design with convenient controls and 360° rotation18 With a larger distal electrode surface area,19 ENSEAL X1 Large Jaw had significantly less bleeding at the distal tip vs LigaSure Impact™ in thick tissue16 LigaSure Impact™ LigaSure Impact™ 16. Preclinical test of distal tip bleeding (ENSEAL® X1 Large Jaw vs Impact-LF4318) in thick porcine mesentery base (p=0.001). (093443-201029). 17. Preclinical testing...

Expect more with ENSEAL® X1 devices Intelligent energy delivery Adaptive Tissue Technology, powered by the Ethicon GEN11 Generator, uses an advanced algorithm for intelligent and efficient energy delivery. In ENSEAL® X1 devices, it continuously: • Senses changes in tissue and device conditions • Responds with the optimal amount of energy ENSEAL X1 Tissue Sealers produce minimal lateral thermal spread 22, 23, 24 • Delivers precision and efficiency 20 The Intelligence of Adaptive TissueofTechnology The Intelligence Adaptive Tissue Technology Device ENSEAL® X1 Device Tissue Changes Advancing beyond...

ENSEAL* XI devices feature ENSEAL XI Curved Jaw, ENSEAL XI Straight Jaw, and ENSEAL XI Large Jaw are supplied sterile for singlepatient use XI Tissue Sealers are compatible with the Ethicon GENII Generator (software version 2016-1 or later versions) How to order Electronic ordering options All purchase orders are made to Johnson & Johnson Health Care Systems, Inc. (JJHCS). The following electronic order placement methods are preferred: • J&J Gateway (www.jnjgateway.com) - For questions about your order, please visit the website or call T866-JNJ-GATE • Electronic Data Interchange - JJHCS Help...