Catalog excerpts
serving science through innovation modern Cytogenetics Reagents, Equipment, Know-hov/
Open the catalog to page 1The aim of Cytogenetics is the study of cellular constituents concerned with heredity, primarily the structure, fuction, and origin of the chromosomes. The chromosome content, called karyotype, is classified on the basis of both chromosome number and morphology, which are fixed characteristics for a particular species. Theoretically, it is possible to prepare chromosome samples starting from any tissue (or suspension of mitotic cells) providing that appropriate methods are used for the type of cell to be examined. The identification and characterisation of either constitutional or acquired...
Open the catalog to page 2Postnatal analysis Postnatal cytogenetic analysis refers to the karyotyping of samples derived from a variety of tissues: peripheral blood, bone marrow and skin broblast. With a blood sample as small as 0.2 - 0.5 ml, it is possible to set up a suspension culture from which it is easy to obtain enough mitoses to study the karyotype of a subject. After 48 to 96 hours of culture, metaphase chromosomes are harvested and slides prepared for chromosome analysis 4,5. Chromosome analysis may be performed for several indications, including: multiple congenital anomalies in a patient; couples with a...
Open the catalog to page 3ChromosomeSynchro P and M are specically created to optimize the culture of peripheral blood lymphocytes (Medium P) and bone marrow cells (Medium M), and to obtain an extremely efcient cell cycle synchronization for the subsequent chromosomal analysis. The kit is composed by medium P or M, and synchronization kit. The medium is complete, and supplied in ready to use culture tube or in bottles. ChromosomeSynchro guarantees the best quality results for postnatal Cytogenetics in terms of optimal mitotic index through the accurate media formulation, and the highest number of metaphases of...
Open the catalog to page 4Prenatal analysis Prenatal diagnosis to identify fetal genetic disorders started in the early 1970s. Women with pregnancies at increased risk of chromosome abnormality (usually because of maternal age, altered serum metabolites, or ultrasound abnormalities of the fetus) undergo invasive sampling of either amniotic uid (AF), chorionic villi (CVS) or, rarely, fetal blood. Material from these samples is cultured to obtain dividing cells and then harvested and prepared for full karyotype analysis of metaphase chromosomes6. During the last three decades, improved technology for prenatal...
Open the catalog to page 5Amniodish is a support for in situ culture of adherent cells and in particular amniocytes and chorionic villi. Amniodish is a ready to use 35 mm Petri dish including a round coverglass slide. The slide allows to grow the cell in situ and to perform directly chromosomal banding or molecular investigation (i.e. uorescent in situ hybridisation, FISH) avoiding trypsinization step. Amnioslide is a support for in situ culture of adherent cells and in particular amniocytes and chorionic villi. The use of SuperFrost® slide inside the culture chamber allows to perform directly chromosomal banding or...
Open the catalog to page 6Cell Culture Slide AmnioFlask is a modern support for in situ culture of amniocytes, chorionic villi derived cells, and other adherent cells. AmnioFlask is a ask ultrasonically welded to a polystyrene microscope slide. The screw cap guarantees a liquid and gas tight seal to prevent contamination and leakage during ask handling. At the end of the in situ culture the ask is easily removed from the slide, and is possible to perform immediately chromosomal banding or molecular investigation. On the bottom of the slide a barcode label is attached. Barcodes are essential for samples tracking and...
Open the catalog to page 7Equipment EuroClone answers to the need of automation and standardization of procedures in the Cytogenetic labs through a complete range of instruments that allow to improve all the manual operations required by chromosome preparation steps; these devices will ensure excellent results, perfectly reproducible in any environmental condition, and will drastically reduce the time and the work-load. Multislide system for chorionic villi samples with “direct preparation” In situ hybridisation system Quickchrome is an instrument that optimizes the quality of chromosome preparations, obtained from...
Open the catalog to page 8Optichrome Plus® Controlled evaporation chamber for optimized chromosome preparations Robotic dispenser for prenatal Cytogenetics The quality of samples preparations for chromosome analysis depends largely on the environmental conditions in which the nal evaporation of the xative takes place. Given that temperature and humidity are constantly varying, it is easy to understand the requirement for a system that enables cytogenetists to work always under standardized conditions10. Autochrome is a robotic dispenser for automated processing of chromosome preparations from adherent cells...
Open the catalog to page 9Postnatal analysis Cat.No. for EKAMT200 (20/culture tubes) order 2 x EKAMTP; for EKAMT500 (50/culture tubes) order 5 x EKAMTP for EKAMT200M (20/culture tubes) order 2 x EKAMTM; for EKAMT500M (50/culture tubes) order 5 x EKAMTM ChromoLymphoB Proliferation Factor Prenatal analysis Cat.No. Amniomed Plus Amniomed® Plus Amniomed Smart Amnioslide, SuperFrost® SPL Cell Culture Slide - 1 well (Vol. 2.5-5.5 ml) SPL Cell Culture Slide - 2 well (Vol. 1.2-2.5ml) Equipment Cat.No. Optichrome® Plus - Evaporation chamber for optimized chromosome preparations Cooling unit for Optichrome® Plus Autochrome -...
Open the catalog to page 10Related Products Cat.No. Primo® TC Flask 12 cm2 plug seal- screw cap Primo TC Flask 12 cm screw cap- w/filter RPMI 1640 MEDIUM with stable L-Glutamine Primo® TC Flask 25 cm2 plug seal- screw cap RPMI 1640 MEDIUM w/o Folic Acid (FRAGILE X CHROMOSOME MODIFICATION) Primo TC Flask 25 cm screw cap- w/filter RPMI 1640 MEDIUM with L-Glutamine HAM’S NUTRIENT MIXTURE F-10 HAM’S NUTRIENT MIXTURE F-10 with L-Glutamine HAM’S NUTRIENT MIXTURE F-10 with L-Glutamine PBS, phosphate buffered saline, w/o Calcium & Magnesium PBS, phosphate buffered saline, w/o Calcium & Magnesium HANK’S balanced salts...
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