High-Content Screening Station Circularity Factor Automated Image Acquisition and Data Analysis with Deep-Learning Technology IDDO.D 1000000.0 Total Intensity DAPI nsrty DAPI

Much More Than Just High-Content Screening Flexible, Modular, and Robust Hardware The scanR screening station combines the modularity and flexibility of a microscope-based setup with the automation, speed, throughput, and reproducibility needed for high-content screening applications. The system is designed for a range of applications, including standard assays and assay development, and its modularity makes the scanR station adaptable for R&D lab applications and multiuser environments. The scanR system features sophisticated image-analysis and data-analysis software that uses an interactive,...

Comprehensive Life Science Solution Designed for fully automated image acquisition and data analysis, the scanR solution accommodates multiwell plates, slides, and custom-built arrays. The system can handle fixed and live cells, and the screening station specifically targets the requirements for quantitative imaging and image analysis in modern cell biology, molecular biology, systems biology, and medical research. High-speed and highthroughput acquisition with advanced imaging and sample flexibility Full automation, from image acquisition to results, with online analysis Unique cytometric data...

Advanced Acquisition Incorporating Olympus’ high-end IX83 inverted microscope, the scanR system has the flexibility to handle all standard assay formats, including microwell plates and slides, and can be configured to accept custom designs, such as spotted arrays or biochips. Clear Guidance Reduced Phototoxicity The software’s workflow is easy to use, enabling reliable image acquisition and straightforward system configuration. The system delivers accurate, repeatable quantitative measurements to address the needs of scientific screening and assay development. The real-time controller (U-RTCE)...

Powerful Data Visualization and Quantitative Analysis The large amount of data you can collect from your assays necessitates coherent and careful automated quantitative analysis. Analysis can be performed online during acquisition, when the system is connected to a local network, or offline on previously acquired datasets. Analyzing Data Analytical techniques can be as simple as counting cells on display or as complex as ratiometric feature-based analysis of multilabeled objects and subobjects in different cell types or cell compartments. Image analysis is carried out as a logical multistep procedure...

scanR AI—The Power of Deep Learning Olympus’ self-learning microscopy technology makes it possible to establish assays with groundbreaking analysis capabilities. The powerful learning capacity of scanR AI reduces photobleaching and improves acquisition speed, measurement sensitivity, and accuracy, facilitating longer observations with reduced influence on cell viability. What until recently seemed impossible to perform is now feasible with deep learning. Self-Learning Microscopy The system’s fully automated and integrated workflow acquires pairs of images for example data, which the software...

The scanR system is flexible, so you can choose the capabilities that match your application and budget. Measuring Kinetic Parameters The scanR kinetic module enables live cells, nuclei, and other objects to be classified by their time-variant properties. Tracking curves are evaluated based on values (mean static parameters such as intensity, area, ratio, shape factor, etc.) measured over time. All static parameters, such as intensity or the ratio of fluorescence markers, position, size, or shape, can be evaluated and analyzed over time. The curves are condensed into single characteristic values,...

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