Biologics
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Shaping the Future of Bone Repair

The Science of Bone Formation Osteoinductivity, Osteoconductivity, Osteogenesis The body's ability to regenerate bone is dependent on three key factors: osteoinductivity, osteoconductivity and osteogenesis.1-3 DEMINERALIZED BONE MATRIX for OSTEOINDUCTIVITY3 Osteoinductivity is the stem cells' ability to differentiate into osteoblasts through stimulation by local growth factors. Demineralizing the bone exposes the organic cascade of growth factors. These growth factors, or Bone Morphogenetic Proteins (BMPs), are the signaling molecules required for the recruitment, proliferation and...

The Cure for Your Concerns about Bone Graft Performance Optecure is an engineered bone graft for reconstruction of the spine, pelvis and extremities. Its room temperature convenience facilitates rapid mixing with buffer solution or blood. Optecure and Optecure+ccc can be used with autologus bone graft and bone marrow. ® An optimal concentration of demineralized bone matrix (DBM) and a resorbable hydrogel carrier provide for osteoinductivity.4,5* And with cortical cancellous bone chips, Optecure +ccc also provides an impressive 3-D matrix for osteoconductivity. The convenience, constituents...

All Natural Mineral-Collagen Composite Ossigen Ossigen Ossigen is a mineral-collagen composite matrix processed into blocks for the repair of bony defects in the spine, extremities and pelvis. The mineral particles are dispersed within collagen fibers, forming a three-dimensional porous matrix consisting of 80 percent bone mineral and 20 percent collagen by dry weight. ® Ossigen is provided as a sterile, dry material that is hydrated with autogenous bone marrow at the point of use. Ossigen blocks may be cut into shapes, and they are designed to retain their shape and physical integrity...

The Optimal Matrix OpteMx is an engineered biomaterial that chemically and structurally mimics cancellous bone. More than 20 years of clinical use provides a foundation of confidence for your desired regenerative outcomes.10 ® Human cancellous bone is comprised of more than 50 percent Hydroxyapatite (HA). OpteMx is a biocompatible, osteoconductive scaffold. Its chemical composition of 60 percent HA and 40 percent Beta-Tricalcium Phosphate (ß-TCP) inhibits premature resorption, leading to effective host bone formation.10 OpteMx, like human cancellous bone, is 60-80 percent porous and is...

Accelerate CONCENTRATING SYSTEM Accelerate® is a platelet concentrating system that offers high yields through gentle centrifugal action, which preserves the fragile buffycoat layer. The Accelerate Concentrating System is designed to be used for the safe and rapid preparation of autologous platelet rich plasma (PRP) from a small sample of blood at the patient's point of care. The PRP can be mixed with autograft and allograft bone prior to application to an orthopedic surgical site as deemed necessary by the clinical use requirements. • Increased platelet concentration (6x)11 •...

Collagen Tendon Wrap TenoMend™ Collagen Tendon Wrap is a resorbable type I collagen matrix that provides a non-constricting encasement for injured tendons. It is designed to be an interface between the tendon and the tendon sheath or the surrounding tissue. When hydrated, TenoMend is a conformable, nonfriable, self-curling collagen sheet designed for easy placement under, around or over the injured tendon. TenoMend provides a protected environment and gliding surface of the sheath for tendon healing. • Patented self-curling design • Proper alignment during surgery • Convenient storage at...

Experience Exactech... A Great Day in the O.R. Founded by an orthopaedic surgeon and a biomedical engineer, Exactech is committed to making every day a great day in the O.R. – for the surgeon, the O.R. staff and above all, for the patient. Exactech’s innovative biologics products can be used as bone void fillers with other implants and instrumentation in total joint replacement procedures where indicated. Exactech products are designed to meet surgeons’ needs throughout the entire case. • Knee: Exactech’s Optetrak®/Opetrak Logic® knee system addresses concerns for contract stress, patellar...

References 1. Goldberg V, et al. Biology of autografts and allografts. Bone and Cartilage Allografts: Biology and Clinical Applications. Edited by V. Goldberg and G. Friedlaender. Park Ridge, IL, American Academy of Orthopaedic Surgeons, 1989, p. 3. 2. McAlister. Principles of Bone Healing. 3. Urist MR, Bone: Formation by Autoinduction. Science, 1965. 150(3698): pp. 893-9. 4. Keller T, et al. Carriers may change osteoinductivity of human demineralized bone in the athymic mouse. The 32nd annual Meeting and Exhibition of the American Academy of Dental Research. 2003 Mar. 5. Data on file at...