CEMEX Advancing the Ordinary Cemex | Cemex Genta I Cemex System | Cemex Accessories I Cemex Automatic Mixer 0BfflCteCli9Surgeon focused. Patient driven.™

Committed to a Common Purpose Exactech started with a dream shared by orthopaedic surgeon Bill Petty, MD, his wife Betty, and biomedical engineer Gary Miller, PhD. Drs. Miller and Petty had worked with several orthopaedic companies and thought they saw some things they could do differently, and better. Stable leadership for 30+ years Fast-growing orthopaedic device company Distribution in more than 30 countries Innovative bone and joint products They wanted to make a difference in the quality of care provided to patients suffering from injuries or arthritic disease. The Pettys and Dr. Miller...

The Cemex Advantage Cemex® is a clinically proven bone cement with long-term success in the fixation of joints.1 Cemex features a unique self-contained delivery system that integrates both the bone cement powder and liquid into an enclosed mixing system while offering surgeons and operating room personnel safety, simplicity and reliability.

Innovation Patented Powder Technology Bone cement is comprised of polymer (Polymethylmethacrylate - PMMA) and liquid monomer (Methylmethacrylate - MMA). The liquid component is necessary to wet the surface of the powder in order to initiate the chemical reaction. Therefore, the surface area of the powder particles dictates the amount of monomer that is required for the polymerization process.

Consistent Particles Thanks to a patented process, Cemex powder particles are consistent in shape and size. The powder has few microparticles and has nearly no irregularities when compared to other commercially available cements (see particle comparison).2 These characteristics result in uniform spheres that yield decreased total surface area. This feature means less monomer is needed to create the cement. Therefore, we were able to develop Cemex with a 3:1 powder to monomer ratio. Because monomer is the more dangerous component, using less monomer decreases risks to patients and O.R. staff....

Less Monomer The more liquid bone cement contains, the more toxic it is to patients, surgeons and O.R. staff directly mixing and applying the bone cement. Cemex uses one-third less liquid than best-selling competitive bone cements, exposing the patient to reduced levels of toxic monomer.4 Cemex has been shown to produce 20 percent less heat than other commercially available formulations.3 Every gram of monomer (liquid component) generates energy equal to 130 Kcal.5 Because of its unique powder component, Cemex requires about 30 percent less liquid than other bone cements, thereby substantially...

LESS SHRINKAGE REDUCED MONOMER LEAKAGE When cement hardens, one of the effects of the chemical reaction is that the cement contracts or “shrinks” This shrinkage is proportional to the . amount of liquid present in the cement mixture.7 By using less liquid than other commercially available formulations, Cemex shrinks 67 percent less than its competitors.8 The shrinkage phenomena is most clearly evidenced with the loosening of the prosthesis and early implant failure. Bone cement with less monomer minimizes the shrinkage phenomena and the likelihood of a revision.7 Leakage occurs when the uncured...

Safety, Simplicity and Reliability Self-Contained Mixing and Delivery System Cemex System is unique because of its pre-loaded liquid and powder components. It features a self-contained delivery system that has been clinically proven in Europe for many years.1 By integrating the bone cement powder and liquid into an enclosed mixing system, Cemex offers safety, simplicity and reliability in bone cement with several advantages. Cemex System is a combined bone cement mixing and delivery system. With no bags to open, no complicated mixing system and no hoses, cement preparation time is minimized....

Minimized Contamination Reduced Toxic Vapors If the technique is followed, the operator should never come into contact with the material during polymerization stages, which eliminates the intrusion of foreign particles (e.g. glass) or bacteria from entering the cement during mixing. Cemex is designed to provide safety through minimized contamination risk. The enclosed system minimizes the release of toxic vapors into the operating room environment—not to mention that Cemex already has 33 percent less monomer than its competitors. Cemex System, combined with the reduced monomer Cemex, is designed...

Clinical Success Patients were examined using RSA tantalum markers, Harris hip score, and conventional radiographs to evaluate cement performance and patient outcomes. The results are summarized in the following: Cemex System has been successfully used in Europe for more than 25 years1,10 and has shown good clinical results in the Swedish Hip and Knee Registry.11,12 Cemex Bone Cement showed no statistically significant differences in a head-to-head prospective randomized, controlled Radiosteriometric Analysis (RSA) study using Palacos as the control.1 “At 10 years, 33 hips could be evaluated...

Advancing the Ordinary We continue to work together to focus on the needs of surgeons and their staff. Cemex Bone Cement’s innovative low monomer formulation has been proven to support longterm fixation of joints.1 Cemex features a unique self-contained delivery system that integrates both the bone cement powder and liquid into an enclosed mixing system while offering surgeons and operating room personnel safety, simplicity and reliability Cemex truly is Advancing the Ordinary.

Body Push Knob Gasket Ampoule Percussion Unit Pressurization Disk Ampoule Breaker Cemex® System Diagram References 1. Söderlund P, et al. 10-year results of a new low-monomer cement: follow-up of a randomized RSA study. Acta Orthop. 2012 Dec;83(6):6048. doi: 10.3109/17453674.2012.742392. Epub 2012 Nov 1. 6. Khün D. Bone Cements: Up to date comparison of physical and chemical properties of commercial materials. Berlin: Springer. 2000. 27-9. 2. Images supplied by Tecres, S.p.A., Italy. 3. Data on file (TEC2000-55 Rev00) at Tecres, S.p.A., Italy. 2000. 8. Trieu H, et al. Comparative measurement...